Oral Leucine Supplementation Is Sensed by the Brain but neither Reduces Food Intake nor Induces an Anorectic Pattern of Gene Expression in the Hypothalamus

Adverse Effects of Excessive Leucine Intake Depend on Dietary Protein Intake: A Transcriptomic Analysis to Identify Useful Biomarkers

(2013) Wataru IMAMURA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues

(2013) Xiang Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes

(2013) Jana Drgonova et al.   PLoS One

Leucine Supplementation Protects from Insulin Resistance by Regulating Adiposity Levels

(2013) Elke Binder et al.   PLoS One

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

(2012) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dietary l-leucine and l-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity

(2012) Anne Freudenberg et al.   AMINO ACIDS

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Lipid Sensing and Insulin Resistance in the Brain

(2012) Jessica T.Y. Yue et al.   Cell Metabolism

Brainstem Nutrient Sensing in the Nucleus of the Solitary Tract Inhibits Feeding

(2012) Clemence Blouet et al.   Cell Metabolism

Leucine Improves Glucose and Lipid Status in Offspring from Obese Dams, Dependent on Diet Type, but not Caloric Intake

(2012) H. Chen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Leucine Is Essential for Attenuating Fetal Growth Restriction Caused by a Protein-Restricted Diet in Rats

(2012) Gabriela Fullin Resende Teodoro et al.   JOURNAL OF NUTRITION

Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice

(2012) Anne Freudenberg et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing

(2012) Hugues Magne et al.   JOURNAL OF PHYSIOLOGY-LONDON

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

(2012) Kevin W Williams et al.   NATURE NEUROSCIENCE

Effects of a Leucine and Pyridoxine-Containing Nutraceutical on Fat Oxidation, and Oxidative and Inflammatory Stress in Overweight and Obese Subjects

(2012) Michael B. Zemel et al.   Nutrients

Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach

(2011) Gilbert Zeanandin et al.   AGE

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

(2011) Mahesh M. Karnani et al.   NEURON

Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats

(2011) Daiana Vianna et al.   NUTRITION

Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to a high-fat diet

(2011) Francisco L Torres-Leal et al.   Nutrition & Metabolism

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Leucine supplementation favors liver protein status but does not reduce body fat in rats during 1 week of food restriction

(2010) Rogerio G. Pedrosa et al.   Applied Physiology Nutrition and Metabolism

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

(2010) Kaiying Guo et al.   Nutrition & Metabolism

Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus

(2010) N. López et al.   PEPTIDES

Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men

(2009) Suzanne Verhoeven et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit

(2009) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

Leucine Supplementation of Drinking Water Does Not Alter Susceptibility to Diet-Induced Obesity in Mice

(2009) Ali Nairizi et al.   JOURNAL OF NUTRITION

Male and female odors induce Fos expression in chemically defined neuronal population

(2009) Jose Donato et al.   PHYSIOLOGY & BEHAVIOR