Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues

Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up

(2012) Gianluca Perseghin et al.   ACTA DIABETOLOGICA

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin

(2012) M K Piya et al.   JOURNAL OF ENDOCRINOLOGY

Leucine Improves Glucose and Lipid Status in Offspring from Obese Dams, Dependent on Diet Type, but not Caloric Intake

(2012) H. Chen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk

(2012) Scott M. Grundy   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells

(2012) Albert Salehi et al.   Nutrition & Metabolism

The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

(2012) Bodo C Melnik et al.   Nutrition & Metabolism

Metabolic Control by S6 Kinases Depends on Dietary Lipids

(2012) Tamara R. Castañeda et al.   PLoS One

An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats

(2011) Jeffrey R. Bernard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes

(2011) Bhumsoo Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons

(2011) Bhumsoo Kim et al.   ENDOCRINOLOGY

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Excess Exposure to Insulin Is the Primary Cause of Insulin Resistance and its Associated Atherosclerosis

(2011) Wenhong Cao et al.   Current Molecular Pharmacology

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

(2010) Giuseppe D'Antona et al.   Cell Metabolism

Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance☆

(2010) Michèle Balage et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells

(2010) Leonie E. C. van Meijl et al.   MOLECULAR NUTRITION & FOOD RESEARCH

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

(2010) Kaiying Guo et al.   Nutrition & Metabolism

Leucine metabolism in regulation of insulin secretion from pancreatic beta cells

(2010) Jichun Yang et al.   NUTRITION REVIEWS

Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance

(2009) Hui-Yu Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

High Fat and Highly Thermolyzed Fat Diets Promote Insulin Resistance and Increase DNA Damage in Rats

(2009) Adriano M. de Assis et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Leucine Supplementation of Drinking Water Does Not Alter Susceptibility to Diet-Induced Obesity in Mice

(2009) Ali Nairizi et al.   JOURNAL OF NUTRITION

Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway

(2009) Eliane Filiputti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Oxidative Stress and Peroxisome Proliferator-Activated Receptor   Coactivator-1  in Hepatic Insulin Resistance

(2008) N. Kumashiro et al.   DIABETES

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE