Rupatadine Protects against Pulmonary Fibrosis by Attenuating PAF-Mediated Senescence in Rodents

Targeting TLR2 Attenuates Pulmonary Inflammation and Fibrosis by Reversion of Suppressive Immune Microenvironment

(2014) H.-Z. Yang et al.   JOURNAL OF IMMUNOLOGY

Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells

(2013) Hong Liu et al.   Autophagy

Caveolin-1 Deficiency Protects from Pulmonary Fibrosis by Modulating Epithelial Cell Senescence in Mice

(2012) Pooja Shivshankar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenic Mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages

(2012) Marcelle RM Andrade et al.   BMC MICROBIOLOGY

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction

(2012) Shaun A. Summers et al.   KIDNEY INTERNATIONAL

New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

(2012) Isis E Fernandez et al.   LANCET

Immunophenotyping of Circulating T Helper Cells Argues for Multiple Functions and Plasticity of T Cells In Vivo in Humans - Possible Role in Asthma

(2012) Carina Malmhäll et al.   PLoS One

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

M2 Polarized Macrophages and Giant Cells Contribute to Myofibrosis in Neuromuscular Sarcoidosis

(2011) Stefan Prokop et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury

(2011) Hong-Zhen Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Pirfenidone

(2011) Natalie J. Carter   DRUGS

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Bleomycin induced lung fibrosis increases work of breathing in the mouse

(2011) Jonathan E. Phillips et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Rupatadine for the treatment of allergic rhinitis and urticaria

(2010) Martin Metz et al.   Expert Review of Clinical Immunology

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation

(2010) Elizabeth F. Redente et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Strategies for treating idiopathic pulmonary fibrosis

(2010) R. M. du Bois   NATURE REVIEWS DRUG DISCOVERY

Global Impairment of CD4+CD25+FOXP3+Regulatory T Cells in Idiopathic Pulmonary Fibrosis

(2009) Ioannis Kotsianidis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a ‘thorough QT/QTc study’ performed according to ICH guidelines

(2009) Ester Donado et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Histamine H1-receptor antagonists with immunomodulating activities: potential use for modulating T helper type 1 (Th1)/Th2 cytokine imbalance and inflammatory responses in allergic diseases

(2009) T. Okamoto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Th9 and allergic disease

(2009) Pejman Soroosh et al.   IMMUNOLOGY

TH1/TH2 balance in concomitant immediate and delayed-type hypersensitivity diseases

(2009) Luane Marques de Mello et al.   IMMUNOLOGY LETTERS

Rupatadine Inhibits Proinflammatory Mediator Secretion from Human Mast Cells Triggered by Different Stimuli

(2009) Magdalini Vasiadi et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Histamine stimulates human lung fibroblast migration

(2009) Tadashi Kohyama et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mast Cells and Gastrointestinal Dysmotility in the Cystic Fibrosis Mouse

(2009) Robert C. De Lisle et al.   PLoS One

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease

(2009) Takao Tsuji et al.   RESPIRATION

Chymase mediates paraquat-induced collagen production in human lung fibroblasts

(2009) Yaw-Dong Lang et al.   TOXICOLOGY LETTERS

The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis

(2008) H. Patrick McNeil et al.   ARTHRITIS AND RHEUMATISM

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

The IL-17 cytokine family and their role in allergic inflammation

(2008) Yui-Hsi Wang et al.   CURRENT OPINION IN IMMUNOLOGY

Pharmacological profile, efficacy and safety of rupatadine in allergic rhinitis

(2008) Subodh Katiyar et al.   Primary Care Respiratory Journal