Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

Microglia, Lifestyle Stress, and Neurodegeneration

(2020) Charlotte Madore et al.   IMMUNITY

Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

(2020) Peng Chen et al.   NEURON

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder

(2020) Daniel Lustberg et al.   PSYCHOPHARMACOLOGY

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

(2020) Eléonore Beurel et al.   NEURON

Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress

(2020) Zixuan Cai et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

CaImAn an open source tool for scalable calcium imaging data analysis

(2019) Andrea Giovannucci et al.   eLife

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

(2019) Georgia Gunner et al.   NATURE NEUROSCIENCE

Lower synaptic density is associated with depression severity and network alterations

(2019) Sophie E. Holmes et al.   Nature Communications

A neural circuit for comorbid depressive symptoms in chronic pain

(2019) Wenjie Zhou et al.   NATURE NEUROSCIENCE

A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain

(2019) Yan Jin et al.   PAIN

Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome

(2019) Joana S. Cruz-Pereira et al.   Annual Review of Psychology

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

(2019) Sebastian Werneburg et al.   IMMUNITY

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats

(2018) Inssaf Berkiks et al.   BIOMEDICINE & PHARMACOTHERAPY

Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges

(2018) Frances K. Johnson et al.   BRAIN BEHAVIOR AND IMMUNITY

Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials

(2018) Joshua D. Rosenblat et al.   JOURNAL OF AFFECTIVE DISORDERS

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

(2018) Xiang Nie et al.   NEURON

Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex

(2018) Ruohe Zhao et al.   Frontiers in Cellular Neuroscience

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

(2018) Tuan Leng Tay et al.   Frontiers in Molecular Neuroscience

The Microtubule-Modulating Drug Epothilone D Alters Dendritic Spine Morphology in a Mouse Model of Mild Traumatic Brain Injury

(2018) Jyoti A. Chuckowree et al.   Frontiers in Cellular Neuroscience

Population coding of valence in the basolateral amygdala

(2018) Xian Zhang et al.   Nature Communications

REM sleep selectively prunes and maintains new synapses in development and learning

(2017) Wei Li et al.   NATURE NEUROSCIENCE

Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2

(2017) Catherine J. Peña et al.   SCIENCE

Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders

(2017) Amin Mottahedin et al.   Frontiers in Cellular Neuroscience

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

(2017) Wei Liu et al.   NEURAL PLASTICITY

Early-Life Adversity and Physical and Emotional Health Across the Lifespan: A Neuroimmune Network Hypothesis

(2016) Robin Nusslock et al.   BIOLOGICAL PSYCHIATRY

Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety- and depression-like behaviors, hippocampal inflammation, and HPA axis activity in adult mice

(2016) Jafar Majidi et al.   BRAIN RESEARCH BULLETIN

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

(2016) Tim V. P. Bliss et al.   NATURE REVIEWS NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Golgi-Cox Staining Step by Step

(2016) Sami Zaqout et al.   Frontiers in Neuroanatomy

Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia

(2016) S Giovanoli et al.   Translational Psychiatry

Systemic inflammation and microglial activation: systematic review of animal experiments

(2015) Inge C.M. Hoogland et al.   Journal of Neuroinflammation

Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α

(2015) D Baumeister et al.   MOLECULAR PSYCHIATRY

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

(2015) Ismini E. Papageorgiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model

(2014) Diego A. Pizzagalli   Annual Review of Clinical Psychology

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Immune Activation Promotes Depression 1 Month After Diffuse Brain Injury: A Role for Primed Microglia

(2013) Ashley M. Fenn et al.   BIOLOGICAL PSYCHIATRY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function

(2013) Frederick Walker et al.   CURRENT DRUG TARGETS

The Role of Early Life Stress in Adult Psychiatric Disorders

(2013) Clara Passmann Carr et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Inflammation and the two-hit hypothesis of schizophrenia

(2013) Keith A. Feigenson et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice

(2013) S. Giovanoli et al.   SCIENCE

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways

(2012) Ana-Maria Gan et al.   CELL AND TISSUE RESEARCH

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Inflammation in neurological and psychiatric diseases

(2012) Parto S. Khansari et al.   INFLAMMOPHARMACOLOGY

A neuroimmunological perspective on anxiety disorders

(2011) Ruihua Hou et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY