Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells

Type 1 TNF Receptor Forms a Complex with and Uses Jak2 and c-Src to Selectively Engage Signaling Pathways That Regulate Transcription Factor Activity

(2014) R. Pincheira et al.   JOURNAL OF IMMUNOLOGY

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells

(2012) A Papi et al.   CELL DEATH AND DIFFERENTIATION

Stem cells in breast tumours: Are they ready for the clinic?

(2012) Matthew P. Ablett et al.   EUROPEAN JOURNAL OF CANCER

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

(2012) Keiyo Takubo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy

(2012) Renato Galzio et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan

(2011) Alexander M. Kulminski et al.   AGING CELL

Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example

(2011) Massimiliano Bonafè et al.   BIOESSAYS

TGF /TNF -Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype

(2011) M. K. Asiedu et al.   CANCER RESEARCH

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2

(2011) Nils Pfaff et al.   EMBO REPORTS

The cancer stem cell niche-there goes the neighborhood?

(2011) Stephanie M. Cabarcas et al.   INTERNATIONAL JOURNAL OF CANCER

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain

(2011) Eliska Svastova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Breast cancer — one term, many entities?

(2011) Nicholas R. Bertos et al.   JOURNAL OF CLINICAL INVESTIGATION

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

(2011) Hasan Korkaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Insight into the heterogeneity of breast cancer through next-generation sequencing

(2011) Hege G. Russnes et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

Cross-Talk between Apolipoprotein E and Cytokines

(2011) Hongliang Zhang et al.   MEDIATORS OF INFLAMMATION

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6

(2011) Ken Saito et al.   NUCLEIC ACIDS RESEARCH

Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer

(2011) K Kim et al.   ONCOGENE

Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells

(2011) Jenny A. Rudnick et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

(2011) Vinagolu K. Rajasekhar et al.   Nature Communications

SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24- Phenotype

(2010) Poornima Bhat-Nakshatri et al.   BMC CANCER

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

RXRγ and PPARγ ligands in combination to inhibit proliferation and invasiveness in colon cancer cells

(2010) Alessio Papi et al.   CANCER LETTERS

miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1

(2010) Stephanie Ma et al.   Cell Stem Cell

TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells

(2010) Yuh-Ching Twu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

WY-14 643, a Selective PPARα Agonist, Induces Proinflammatory and Proangiogenic Responses in Human Ocular Cells

(2010) Jin-Zhong Zhang et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Breast Cancer Stem Cells

(2010) Suling Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor   Expression

(2010) E. K. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

NF-κB addiction and its role in cancer: ‘one size does not fit all’

(2010) M M Chaturvedi et al.   ONCOGENE

Combined Low Doses of PPARγ and RXR Ligands Trigger an Intrinsic Apoptotic Pathway in Human Breast Cancer Cells

(2009) Daniela Bonofiglio et al.   AMERICAN JOURNAL OF PATHOLOGY

The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy

(2009) E Y Tan et al.   BRITISH JOURNAL OF CANCER

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity

(2009) Seon-Ah Ha et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PPARγ and RXRγ ligands act synergistically as potent antineoplastic agentsin vitroandin vivoglioma models

(2009) Alessio Papi et al.   JOURNAL OF NEUROCHEMISTRY

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients

(2008) Nai-Wen Chang et al.   CLINICA CHIMICA ACTA

The many faces of PPARγ: Anti-inflammatory by any means?

(2008) Attila Szanto et al.   IMMUNOBIOLOGY

TNFα acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-κB-dependent pathways

(2007) Martín A. Rivas et al.   EXPERIMENTAL CELL RESEARCH