Article
Medicine, Research & Experimental
Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Marcella Ramos Sant'Ana, Guilherme Francisco Peruca, Chadi Pellegrini Anaruma, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: The study showed that short-term combined training can reduce glucose levels and fatty liver, improve hepatic insulin sensitivity, and reduce complications caused by fatty liver.
Article
Biochemistry & Molecular Biology
Helena Leal, Joao Cardoso, Patricia Valerio, Marta Quatorze, Vitor Carmona, Janete Cunha-Santos, Luis Pereira de Almeida, Claudia Pereira, Claudia Cavadas, Pedro Gomes
Summary: The protein SIRT2 is found to play a role in the regulation of hepatic lipid metabolism and its activation might be a therapeutic strategy against obesity and its metabolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bin Jiang, Dongdong Wang, Yunfu Hu, Wenxuan Li, Fengjiang Liu, Xudong Zhu, Xiaoyu Li, Hanwen Zhang, Hui Bai, Qing Yang, Xiuna Yang, Jingjing Ben, Qi Chen
Summary: This study investigates the role of serum amyloid A1 (SAA1) in obesity-induced hepatic inflammation and nonalcoholic fatty liver disease (NAFLD). The results show that SAA1 is increased in the liver of NAFLD patients and mice, and it triggers hepatic steatosis and inflammation by forming a SAA1/Toll-like receptor 4 (TLR4)/NF-KB/SAA1 feedforward regulatory circuit.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Summary: The CX3CL1-CX3CR1 system is crucial in regulating inflammation, particularly in obese mice with adipose tissue inflammation and insulin resistance. Deficiency in CX3CR1 signaling leads to an increase in M1 polarized macrophages, worsening glucose tolerance and insulin resistance in obese mice. Targeting the CX3CL1-CX3CR1 system may be beneficial in treating type 2 diabetes by modulating M1/M2 macrophages.
Article
Endocrinology & Metabolism
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Summary: The CX3CL1-CX3CR1 system regulates inflammation in obese mice by affecting adipose tissue macrophage recruitment and polarization, leading to insulin resistance. Deficiency in CX3CR1 signaling results in a dominant shift towards M1-polarized macrophages, exacerbating insulin resistance in obese mice. Therapies targeting CX3CL1-CX3CR1 system may be beneficial for treating type 2 diabetes by modulating M1/M2 macrophages.
Article
Biochemistry & Molecular Biology
Tarun Mahata, Abhishek Singh Sengar, Madhuri Basak, Kiran Das, Arnab Pramanick, Sumit Kumar Verma, Praveen Kumar Singh, Sayan Biswas, Subhasish Sarkar, Sudipta Saha, Suvro Chatterjee, Madhusudan Das, Adele Stewart, Biswanath Maity
Summary: RGS6 plays a critical role in non-alcoholic fatty liver disease by exacerbating oxidative stress and cell death, with inhibition providing a means to prevent or reverse liver damage.
Article
Food Science & Technology
Jhih-Wei Hsu, Chung-Yi Nien, Hsin-Wei Chen, Feng-Yuan Tsai, Szu-Ching Yeh, Yung-Hsi Kao, Tsui-Chun Tsou
Summary: This study found that DEHP exposure exacerbated metabolic disorders in obese mice, but not in lean mice. The synergistic effects of obesity and DEHP regulated carbohydrate uptake, lipolysis, and abnormal adipose tissue, while obesity and DEHP differentially modulated transcriptomic changes in hepatic tissue.Obesity and DEHP exposure together caused early onset of metabolic disorders in obese mice through a potential mechanism involving Pparg, Lipe, Cd44, and Irs1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Gastroenterology & Hepatology
Junyong Wang, Junpeng Ma, Hongyu Nie, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Hongliang Li, Yan-Xiao Ji, Jingjing Cai
Summary: The study found that RGS5 protects against NAFLD and nonalcoholic steatohepatitis, and that it is negatively associated with mitogen-activated protein kinase signaling cascades in response to metabolic challenges. RGS5 directly interacts with TAK1, inhibits its hyperphosphorylation, and prevents the activation of the downstream JNK/p38 signaling cascade.
Article
Medicine, Research & Experimental
Lingyan Ma, Yinhua Ni, Luting Hu, Yufeng Zhao, Liujie Zheng, Song Yang, Liyang Ni, Zhengwei Fu
Summary: Spermidine administration can reduce fat mass and plasma lipid profile in HFD-induced obese mice, improve hepatic steatosis, reduce adipose tissue inflammation, and enhance gut barrier function. Additionally, spermidine treatment also enhances thermogenic gene expression in brown adipose tissue.
Article
Plant Sciences
Laxmi Sen Thakuri, Chul Min Park, Hyeon-A Kim, Hyung Jung Kim, Jin Woo Park, Jong Cheol Park, Dong Young Rhyu
Summary: Red seaweed has a long history in traditional Asian medicine and has been used to address various conditions. This study investigated the effects of a specific red seaweed extract on liver injury and lipid and glucose dysregulation, finding promising results.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Medicinal
Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Hye Gwang Jeong
Summary: Puerarin activates GPER to regulate lipid metabolism and improve hepatic steatosis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Food Science & Technology
Shuo Li, Jinming You, Zirui Wang, Yue Liu, Bo Wang, Min Du, Tiande Zou
Summary: The study showed that curcumin can alleviate hepatic steatosis and insulin resistance in high-fat diet-fed obese mice by modulating gut microbiota composition and metabolites.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Evelyn A. A. Bates, Zachary A. A. Kipp, Genesee J. J. Martinez, Olufunto O. O. Badmus, Mangala M. M. Soundarapandian, Donald Foster, Mei Xu, Justin F. F. Creeden, Jennifer R. R. Greer, Andrew J. J. Morris, David E. E. Stec, Terry D. D. Hinds
Summary: By using GNUR treatment in mice with NAFLD, the study found that it can increase plasma bilirubin levels, decrease plasma urobilin levels, reduce liver fat content and ceramide production, lower blood glucose and insulin levels, and decrease inflammatory mediators, thus improving overall liver health.
Article
Cell Biology
Tingting Song, Wusa Qin, Zeliang Lai, Haoyu Li, Daihan Li, Baojia Wang, Wuquan Deng, Tingzhang Wang, Liming Wang, Rui Huang
Summary: In this study, the researchers found that a protein-rich diet reduced body fat storage in fruit flies by increasing the production of the neuropeptide FMRFamide. The enhanced FMRFamide activity led to increased energy expenditure, decreased food intake, and promoted lipolysis. The researchers also demonstrated that the dietary cysteine worked in a similar way in mice via neuropeptide FF signaling. Additionally, the administration of dietary cysteine or FMRFa/NPFF showed protective effects against metabolic stress without causing behavioral abnormalities.