Puerarin attenuates hepatic steatosis via G‐protein‐coupled estrogen receptor‐mediated calcium and SIRT1 signaling pathways

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

(2020) Geetanjali Sharma et al.   Science Translational Medicine

17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells

(2020) Wei Fu et al.   Frontiers in Endocrinology

Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells

(2019) Luciana Gomes et al.   Scientific Reports

G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer

(2019) Shen Xu et al.   Frontiers in Endocrinology

GPCR-SSFE 2.0—a fragment-based molecular modeling web tool for Class A G-protein coupled receptors

(2017) Catherine L. Worth et al.   NUCLEIC ACIDS RESEARCH

Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway

(2017) Xu Ma et al.   PLoS One

Resveratrol ameliorates lipid accumulation in HepG2 cells, associated with down-regulation of lipin1 expression

(2016) Li Ying Tang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP+-Induced SH-SY5Y Cell Death

(2016) Yue-Fa Cheng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue

(2016) Sun-Joong Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

(2016) Christopher G. Langendorf et al.   Nature Communications

Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors

(2016) Hongyan Qian et al.   Journal of Immunology Research

Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes

(2015) OK-HWA KANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of Puerarin on Lipid Accumulation and Metabolism in High-Fat Diet-Fed Mice

(2015) Guodong Zheng et al.   PLoS One

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

(2014) Hee Yun et al.   FEBS Journal

Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis

(2014) Kathryn E. Davis et al.   HORMONES AND BEHAVIOR

Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway

(2014) Yi Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

GPER Deficiency in Male Mice Results in Insulin Resistance, Dyslipidemia, and a Proinflammatory State

(2013) Geetanjali Sharma et al.   ENDOCRINOLOGY

GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion

(2013) Pei Zhu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

3-Caffeoyl, 4-dihydrocaffeoylquinic acid fromSalicornia herbaceaattenuates high glucose-induced hepatic lipogenesis in human HepG2 cells through activation of the liver kinase B1 and silent information regulator T1/AMPK-dependent pathway

(2013) Yong Pil Hwang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Puerarin: A Review of Pharmacological Effects

(2013) Yan-Xi Zhou et al.   PHYTOTHERAPY RESEARCH

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

Molecular Mechanisms of Estrogen Receptors' Suppression of Lipogenesis in Pancreatic β-Cells

(2012) Joseph P. Tiano et al.   ENDOCRINOLOGY

Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells

(2012) Yung-Ting Kuo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes

(2011) T. Kendall Harden et al.   CHEMICAL REVIEWS

Insulinotropic and Antidiabetic Effects of 17β-Estradiol and the GPR30 Agonist G-1 on Human Pancreatic Islets

(2011) Rajesh Kumar et al.   ENDOCRINOLOGY

Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation

(2011) Ying-Ying Chen et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

Estrogen receptors mediate rapid activation of phospholipase C pathway in the rat endometrium

(2011) Vivian C. Konigame et al.   STEROIDS

Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice

(2010) Alexander Balhuizen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic Adenosine Monophosphate Response Element-Binding Protein Phosphorylation and Neuroprotection by 4-Phenyl-1-(4-Phenylbutyl) Piperidine (PPBP)

(2009) Sufang Yang et al.   ANESTHESIA AND ANALGESIA

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

(2009) Teayoun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta

(2009) Li-Ping Yan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effects of synthetic and plant-derived selective modulators of estrogen receptors on depression-like behavior of female rats

(2008) N. S. Sapronov et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: Estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1

(2008) Yong Pil Hwang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fatty Liver

(2007) Anna Kotronen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY