Article
Neurosciences
Qing Wang, Yachen Shi, Xinyang Qi, Lingyu Qi, Xiang Chen, Jingping Shi, Chunming Xie, Zhijun Zhang
Summary: This study found an association between platelet proteins and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). The platelet AβPP ratio was found to be a sensitive identifier for differentiating AD from non-AD pathologies. Additionally, phosphorylated tau levels were elevated in both AD and non-AD groups compared to normal controls.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Geriatrics & Gerontology
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan
Summary: Decades of research have shown that amyloid-beta (Aβ) plays an undeniable role in the development of Alzheimer's disease (AD). However, the focus on the pathological effects of Aβ may overshadow the significance of its metabolic precursor, amyloid precursor protein (APP), in the occurrence and progression of AD. This review explores the various roles of APP in AD, including its structure, functions, enzymatic processing, and potential therapeutic approaches to targeting APP to ameliorate AD pathologies and halt disease progression.
Article
Clinical Neurology
Lei Liu, Hyunchang Kwak, Trebor L. Lawton, Shan-Xue Jin, Angela L. Meunier, Yifan Dang, Beth Ostaszewski, Alison C. Pietras, Andrew M. Stern, Dennis J. Selkoe
Summary: The study developed a new method for detecting and quantifying soluble oligomers of amyloid beta protein in human plasma. The method is highly sensitive, cost-effective, and suitable for high throughput analysis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biology
Pascal Dominic Rem, Vita Sereikaite, Diego Fernandez-Fernandez, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salome Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Stromgaard, Bernhard Bettler
Summary: Amyloid-beta precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. A 17 amino acid peptide (APP17) derived from APP binds to the extracellular sushi domain 1 (SD1) of GABA(B) receptors (GBRs). However, APP17 does not influence GBR activity in heterologous cells, indicating that sAPP exerts its neuronal effects through receptors other than GBRs.
Review
Neurosciences
Rebecca M. C. Gabriele, Emily Abel, Nick C. Fox, Selina Wray, Charles Arber
Summary: Amyloid precursor protein (APP) and its cleavage fragment Amyloid-beta (A beta) play crucial roles in Alzheimer's disease (AD). Genetic alterations that increase the overall dosage of APP or favor the generation of more aggregation-prone A beta species directly contribute to the disease. Lowering APP expression is an attractive approach for AD treatment and prevention. New technologies that reduce APP expression may offer disease modification and slow clinical progression.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Jinsu Park, Meenu Madan, Srinivasulu Chigurupati, Seung Hyun Baek, Yoonsuk Cho, Mohamed R. Mughal, Amin Yu, Sic L. Chan, Jogi Pattisapu, Mark P. Mattson, Dong-Gyu Jo
Summary: AQP1 levels are elevated in the cerebral cortex during the early stages of AD, particularly in vulnerable neurons, and increase as aging progresses in AD mouse models. AQP1 appears to reduce A beta production by inhibiting the binding between BACE1 and APP.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Marc Vervuurt, Xiaoyue Zhu, Joseph Schrader, Anna M. Kort, Taina M. Marques, Iris Kersten, Annemieke M. Peters van Ton, Wilson F. Abdo, Floris H. B. M. Schreuder, Ingeborg Rasing, Gisela M. Terwindt, Marieke J. H. Wermer, Steven M. Greenberg, Catharina J. M. Klijn, H. Bea Kuiperij, William E. Van Nostrand, Marcel M. Verbeek
Summary: The aim of this study was to investigate the relationship between urokinase plasminogen activator (uPA) and cerebral amyloid angiopathy (CAA). The results showed that increased cerebrovascular expression of uPA in CAA is associated with elevated levels of uPA in cerebrospinal fluid (CSF), suggesting that uPA could serve as a biomarker for CAA.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yoonsuk Cho, Han-Gyu Bae, Eitan Okun, Thiruma V. Arumugam, Dong-Gyu Jo
Summary: APP is an evolutionarily conserved transmembrane protein that serves as a precursor to amyloid-beta peptides, which are implicated in Alzheimer's disease. Studies have shown diverse pathological and physiological functions of APP and its cleavage products, but their roles are not fully understood. Current research focuses on APP processing and potential therapeutic approaches for Alzheimer's disease.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoling Liu, Yan Liu, Shangrong Ji
Summary: Alzheimer's disease is a common neurodegenerative disease that increases in prevalence with age. Studies suggest that abnormalities in the metabolism of APP are a major pathological feature of AD, with secretases playing a key role in APP processing. Research on secretases in the processing of APP could potentially lead to new directions for AD therapy.
Article
Neurosciences
Zuo-Teng Wang, Kun-Yan Li, Chen-Chen Tan, Wei Xu, Xue-Ning Shen, Xi-Peng Cao, Ping Wang, Yan-Lin Bi, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: This study examined the associations between alcohol consumption and CSF AD biomarkers in cognitively intact older adults, revealing that frequent drinking was significantly associated with higher CSF p-Tau/Aβ and tTau/Aβ levels. Additionally, frequent drinking was found to be related to greater pTau and tTau abnormalities in older participants.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Dominique Gouilly, Camille Tisserand, Leonor Nogueira, Laura Saint-Lary, Vanessa Rousseau, Marie Benaiteau, Marie Rafiq, Jasmine Carlier, Emilie Milongo-Rigal, Jean-Christophe Pages, Jeremie Pariente
Summary: The consistency between cerebrospinal fluid amyloid-beta (A beta(42/40) ratio and A beta(42) in the AT(N) classification system is limited. Most false A+T- patients were not clinically diagnosed with Alzheimer's disease. Therefore, the interchangeability of A beta(42/40) ratio and A beta(42) is restricted in classifying patients in a clinical setting using the AT(N) scheme.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Soyeon Kim, Kiwon Kim, Kwangsik Nho, Woojae Myung, Hong-Hee Won
Summary: The study found a causal association between CSF biomarkers and the risk of LOAD, suggesting that the etiology of LOAD involves pathways of A beta and tau proteins. Further MR studies using large-scale data are needed to elucidate the pathophysiology of LOAD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Chemistry, Analytical
Arezoo Mirzaie, Hassan Nasrollahpour, Balal Khalilzadeh, Ali Akbar Jamali, Raymond J. Spiteri, Hadi Youse, Ibrahim Isildak, Reza Rahbarghazi
Summary: Alzheimer's disease is a prevalent neurodegenerative disorder characterized by progressive deterioration, loss of neurons, and cognitive decline. Amyloid beta and Tau proteins are key biomarkers of the disease, and their abnormal levels in biofluids, particularly cerebrospinal fluid, are directly linked to the incidence and progression of Alzheimer's. Developing sensitive and reliable methods for screening and evaluating these biomarkers in cerebrospinal fluid can aid in early diagnosis and treatment. This article discusses the impact of Alzheimer's on cerebrospinal fluid and provides an overview of the latest biosensors for detecting amyloid beta and Tau in cerebrospinal fluid samples.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Ris E. Jansen, Sven J. van der Lee, Duber Gomez-Fonseca, Itziar de Rojas, Maria Carolina Dalmasso, Benjamin Grenier-Boley, Anna Zettergren, Aniket Mishra, Muhammad Ali, Victor Andrade, Celine Bellenguez, Luca Kleineidam, Fahri Kucukali, Yun Ju Sung, Niccolo Tesi, Ellen M. Vromen, Douglas P. Wightman, Daniel Alcolea, Montserrat Alegret, Ignacio Alvarez, Philippe Amouyel, Lavinia Athanasiu, Shahram Bahrami, Henri Bailly, Olivia Belbin, Sverre Bergh, Lars Bertram, Geert Jan Biessels, Kaj Blennow, Rafael Blesa, Merce Boada, Anne Boland, Katharina Buerger, Angel Carracedo, Laura Cervera-Carles, Genevieve Chene, Jurgen A. H. R. Claassen, Stephanie Debette, Jean-Francois Deleuze, Peter Paul de Deyn, Janine Diehl-Schmid, Srdjan Djurovic, Oriol Dols-Icardo, Carole Dufouil, Emmanuelle Duron, Emrah Duezel, Tormod Fladby, Juan Fortea, Lutz Froelich, Pablo Garcia-Gonzalez, Maria Garcia-Martinez, Ina Giegling, Oliver Goldhardt, Johan Gobom, Timo Grimmer, Annakaisa Haapasalo, Harald Hampel, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernandez, Sanna-Kaisa Herukka, Henne Holstege, Jonas Jarholm, Silke Kern, Anne-Brita Knapskog, Anne M. Koivisto, Johannes Kornhuber, Teemu Kuulasmaa, Carmen Lage, Christoph Laske, Ville Leinonen, Piotr Lewczuk, Alberto Lleo, Adolfo Lopez de Munain, Sara Lopez-Garcia, Wolfgang Maier, Marta Marquie, Merel O. Mol, Laura Montrreal, Fermin Moreno, Sonia Moreno-Grau, Gael Nicolas, Markus M. Nothen, Adelina Orellana, Lene Palhaugen, Janne M. Papma, Florence Pasquier, Robert Perneczky, Oliver Peters, Yolande A. L. Pijnenburg, Julius Popp, Danielle Posthuma, Ana Pozueta, Josef Priller, Raquel Puerta, Ines Quintela, Inez Ramakers, Eloy Rodriguez-Rodriguez, Dan Rujescu, Ingvild Saltvedt, Pascual Sanchez-Juan, Philip Scheltens, Norbert Scherbaum, Matthias Schmid, Anja Schneider, Geir Selbaek, Per Selnes, Alexey Shadrin, Ingmar Skoog, Hilkka Soininen, Lluis Tarraga, Stefan Teipel, Betty Tijms, Magda Tsolaki, Christine Van Broeckhoven, Jasper Van Dongen, John C. van Swieten, Rik Vandenberghe, Jean-Sebastien Vidal, Pieter J. Visser, Jonathan Vogelgsang, Margda Waern, Michael Wagner, Jens Wiltfang, Mandy M. J. Wittens, Henrik Zetterberg, Miren Zulaica, Cornelia M. van Duijn, Maria Bjerke, Sebastiaan Engelborghs, Frank Jessen, Charlotte E. Teunissen, Pau Pastor, Mikko Hiltunen, Martin Ingelsson, Ole A. Andreassen, Jordi Clarimon, Kristel Sleegers, Agustin Ruiz, Alfredo Ramirez, Carlos Cruchaga, Jean-Charles Lambert, Wiesje van der Flier
Summary: This study found that levels of A beta 42 and pTau in cerebrospinal fluid are more direct indicators of the pathogenesis of Alzheimer's disease than clinical diagnosis. Through a collaborative effort, novel associations with AD risk loci and multiple biological pathways related to A beta 42 and pTau were identified.
ACTA NEUROPATHOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Kseniia S. Orobets, Andrey L. Karamyshev
Summary: Alzheimer's disease is a common neurodegenerative disorder associated with age or inherited mutations. It is characterized by severe dementia that affects memory, cognitive functions, and daily life. The disease is linked to the accumulation of cytotoxic amyloid beta and hyperphosphorylated tau protein, as well as other pathological features. Various treatment options, such as antibody-based therapy and stem cell transplantation, are being investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Medical Laboratory Technology
Clement Aveneau, Claire Hourregue, Emmanuel Cognat, Julien Dumurgier, Hugo Vanderstichele, Eugeen Vanmechelen, Henrik Zetterberg, Jacques Hugon, Kaj Blennow, Claire Paquet, Elodie Bouaziz-Amar
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Geriatrics & Gerontology
Archana Singh-Manoux, Amina Oumarou-Ibrahim, Marcos D. Machado-Fragua, Julien Dumurgier, Erics J. Brunner, Mika Kivimaki, Aurore Fayosse, Severine Sabia
Summary: Poor and declining kidney function in older adults is associated with a higher risk of dementia that is not attributable to stroke and persists after accounting for major cardiometabolic conditions.
Article
Clinical Neurology
Constance Delaby, Charlotte E. Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, Elodie Bouaziz Amar, Anne Beaume, Aurelie Bedel, Giovanni Bellomo, Edith Bigot-Corbel, Maria Bjerke, Marie-Celine Blanc-Quintin, Merce Boada, Olivier Bousiges, Miles D. Chapman, Mari L. DeMarco, Mara D'Onofrio, Julien Dumurgier, Diane Dufour-Rainfray, Sebastiaan Engelborghs, Hermann Esselmann, Anne Fogli, Audrey Gabelle, Elisabetta Galloni, Clementine Gondolf, Frederique Grandhomme, Oriol Grau-Rivera, Melanie Hart, Takeshi Ikeuchi, Andreas Jeromin, Kensaku Kasuga, Ashvini Keshavan, Michael Khalil, Peter Koertvelyessy, Agnieszka Kulczynska-Przybik, Jean-Louis Laplanche, Piotr Lewczuk, Qiao-Xin Li, Alberto Lleo, Catherine Malaplate, Marta Marquie, Colin L. Masters, Barbara Mroczko, Leonor Nogueira, Adelina Orellana, Markus Otto, Jean-Baptiste Oudart, Claire Paquet, Federico Paolini Paoletti, Lucilla Parnetti, Armand Perret-Liaudet, Katell Peoc'h, Koen Poesen, Albert Puig-Pijoan, Isabelle Quadrio, Muriel Quillard-Muraine, Benoit Rucheton, Susanna Schraen, Jonathan M. Schott, Leslie M. Shaw, Marc Suarez-Calvet, Magda Tsolaki, Hayrettin Tumani, Chinedu T. Udeh-Momoh, Lucie Vaudran, Marcel M. Verbeek, Federico Verde, Lisa Vermunt, Jonathan Vogelgsang, Jens Wiltfang, Henrik Zetterberg, Sylvain Lehmann
Summary: This study examined the variation in quantifying cerebrospinal fluid (CSF) biomarkers for the diagnosis of Alzheimer's disease (AD) across different centers worldwide and proposed harmonized comments to address inconsistency in interpretation and reporting of results. The findings revealed similarities in (pre-)analytical procedures among centers but significant heterogeneity in cutoff definitions and report comments, leading to the identification of the most accurate and informative comments through consensus for CSF biomarker interpretation in the context of AD diagnosis. This represents the first attempt to propose harmonized reports across specialized laboratories globally involved in AD diagnosis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugere, Vincent Emond, David A. Bennett, Frederic Calon
Summary: This study reveals that impairment of insulin receptors at the blood-brain barrier contributes to brain insulin resistance in Alzheimer's disease, in association with beta-amyloid pathology, based on experiments with human brain samples and animal models.
Editorial Material
Medical Laboratory Technology
Katell Peoc'h
ANNALES DE BIOLOGIE CLINIQUE
(2023)
Article
Medical Laboratory Technology
Alexandre Raynor, Carmen Stefanescu, Arnaud Bruneel, Herve Puy, Katell Peoc'h, Hana Manceau
Summary: We present the case of a 42-year-old woman with chronic enteropathy and acquired atransferrinemia. Despite the absence of detectable serum transferrin, the patient only exhibited mild anaemia, and her haemoglobin concentration remained stable throughout the two-month hospitalization. The acquired atransferrinemia was believed to be secondary to chronic undernutrition, inflammation, and liver failure.
Article
Biochemistry & Molecular Biology
Mohammed Amir Husain, Annick Vachon, Raphael Chouinard-Watkins, Milene Vandal, Frederic Calon, Melanie Plourde
Summary: The metabolism of docosahexaenoic acid (DHA) is different in APOE4 carriers, and it affects cognitive performance. There is a plasma-liver-brain axis of DHA in APOE4 mice, which is influenced by genotype and diet. APOE4 mice rely more on plasma DHA, especially in cognitive performance.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Matthieu Lilamand, Elodie Bouaziz-Amar, Julien Dumurgier, Emmanuel Cognat, Claire Hourregue, Francois Mouton-Liger, Manuel Sanchez, Anne-Cecile Troussiere, Matthieu Martinet, Jacques Hugon, Claire Paquet
Summary: This study examined the associations between plasma leptin levels and cognitive impairment stages, as well as CSF biomarkers in AD. Results showed a negative correlation between plasma leptin levels and CSF β-amyloid concentration, and confirmed the diagnosis of AD through CSF biomarkers.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Stephanie Levert, Julie Pilliod, Etienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frederic Calon, Nicole Leclerc
Summary: In this study, the interaction between Tau and FLNA proteins was explored, as well as the impact of FLNA on Tau pathology. The results showed that overexpression of FLNA led to the accumulation of Tau protein in cells, increased its phosphorylation and cleavage by Caspase-3, but did not increase its aggregation. Additionally, FLNA overexpression also induced the accumulation of annexin A2. However, in AD brains, the increase in FLNA did not correlate with Tau pathology.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medical Laboratory Technology
Elodie Lebredonchel, Alexandre Raynor, Arnaud Bruneel, Katell Peoch, Andre Klein
Summary: In this case, a 39-year-old male of Tamil ethnicity had extremely elevated (20%) carbohydrate-deficient transferrin (CDT) levels measured by capillary electrophoresis. However, further investigation revealed a genetic variant on the TF gene, causing half of the patient's transferrin proteins to lack a complete glycan chain despite no alcohol consumption, explaining the discrepancy between the techniques used. This case highlights the importance of comparing laboratory results with clinical descriptions, performing glycoforms profile analysis, and confirming intriguing results with another technique in a specialized laboratory.
CLINICA CHIMICA ACTA
(2023)
Article
Neurosciences
Olivier Landry, Arnaud Francois, Meryl-Farelle Oye Mintsa Mi-Mba, Marie-Therese Traversy, Cyntia Tremblay, Vincent Emond, David A. Bennett, Karen H. Gylys, Joseph D. Buxbaum, Frederic Calon
Summary: Synaptic loss is closely related to Alzheimer's disease (AD) neuropathology and symptoms. The deficiency of Shank3 protein is associated with severe cognitive symptoms in children. This study found that the loss of Shank3a in the parietal cortex of individuals with AD is associated with cognitive decline. The deficiency of Shank3a in AD mice exacerbates cognitive impairment and anxious behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Juan Lantero-Rodriguez, Agathe Vrillon, Aida Fernandez-Lebrero, Paula Ortiz-Romero, Anniina Snellman, Laia Montoliu-Gaya, Wagner. S. S. Brum, Emmanuel Cognat, Julien Dumurgier, Albert Puig-Pijoan, Irene Navalpotro-Gomez, Greta Garcia-Escobar, Thomas K. Karikari, Eugeen Vanmechelen, Nicholas. J. J. Ashton, Henrik Zetterberg, Marc Suarez-Calvet, Claire Paquet, Kaj Blennow
Summary: CSF p-tau235 is associated with CSF amyloidosis in two independent memory clinic cohorts, accurately identifying Alzheimer's disease in both mild cognitive impairment and dementia patients. The diagnostic performance of CSF p-tau235 in clinical settings is comparable to that of other CSF p-tau measurements, indicating its suitability for supporting a biomarker-based diagnosis of Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Nutrition & Dietetics
Salma Fourati, Annick Hamon, Rita Daclat, Joe-Elie Salem, Katell Peoc'h, Johanne Le Beyec, Francisca Joly, Jean-Marc Lacorte
Summary: This study found that ApoB-48 protein could be used as a marker to assess intestinal function in patients with short bowel syndrome. There was a positive correlation between ApoB-48 and residual small bowel length, and lower levels of ApoB-48 were observed in patients dependent on parenteral nutrition.
Editorial Material
Cell Biology
Aurelie de Rus Jacquet, Sophie Laye, Frederic Calon
Summary: Understanding how natural products promote brain health is crucial for improving the lives of individuals with neurodegenerative disorders. This article discusses the mechanisms involved and recent technological advancements.
CELL REPORTS MEDICINE
(2023)
Article
Geriatrics & Gerontology
Matthieu Lilamand, Agathe Vrillon, Laurent Gonzales-Marabal, Louise Sindzingre, Karl Gotze, Jacques Boddaert, Eric Pautas, Veronique Francois-Fasille, Julien Dumurgier, Claire Paquet
Summary: The aim of this study was to assess the skill level and self-confidence of medical residents in geriatrics in performing lumbar puncture and to evaluate the potential benefits of training with simulation and virtual reality. Findings showed that most residents received insufficient training during their medical school period and emphasized the need for additional lumbar puncture training. Simulation training was associated with a significant increase in self-confidence and a good success rate in real-life clinical practice.
EUROPEAN GERIATRIC MEDICINE
(2023)