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Biology
Silvia Leon, Rajae Talbi, Elizabeth A. McCarthy, Kaitlin Ferrari, Chrysanthi Fergani, Lydie Naule, Ji Hae Choi, Rona S. Carroll, Ursula B. Kaiser, Carlos F. Aylwin, Alejandro Lomniczi, Victor M. Navarro
Summary: In Kiss1 neurons, Nhlh2 plays a role in the metabolic regulation of kisspeptin and NKB synthesis and release, influencing the timing of puberty onset and fertility regulation in male mice.
Article
Biology
Laifu Li, Li-Zi Zhang, Zhi-Xiong He, Huan Ma, Yu-Ting Zhang, Yu-Feng Xun, Wei Yuan, Wen-Juan Hou, Yi-Tong Li, Zi-Jian Lv, Rui Jia, Fa-Dao Tai
Summary: This study using socially monogamous mandarin voles found that neural circuits involving 5-HTergic neurons in the dorsal raphe nucleus and serotonin terminals in the anterior cingulate cortex play a crucial role in consolation-like behaviors and sociability. The release of 5-HT in the ACC and activity of DR neurons were significantly increased during comforting behaviors and social interactions. Activation of 5-HT1A receptors in the ACC was able to reverse deficits in consolation and sociability induced by inhibition of 5-HTergic neurons in the DR.
Article
Multidisciplinary Sciences
Xiaoting Wu, Wade Morishita, Kevin T. Beier, Boris D. Heifets, Robert C. Malenka
Summary: This study identifies the medial septum as a critical input region for social memory formation and demonstrates that serotonin modulation in the medial septum plays a bidirectional role in controlling the stability of social memories.
Article
Multidisciplinary Sciences
Vikram Vijayan, Zikun Wang, Vikram Chandra, Arun Chakravorty, Rufei Li, Stephanie L. Sarbanes, Hessameddin Akhlaghpour, Gaby Maimon
Summary: By studying the choice of egg-laying substrate in Drosophila, we found that flies adjust their egg-laying rates based on the value of recently explored substrates. They compare the current substrate with an internal expectation to regulate egg-laying likelihood. Dopamine neuron activity plays a critical role in learning and expressing this expectation.
Article
Biochemistry & Molecular Biology
Yanlin He, Xing Cai, Hailan Liu, Krisitine M. Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu
Summary: The translation discusses how obesity is primarily caused by consuming excessive calories beyond energetic requirements, while the underlying drivers have not been fully defined. The study found that activating specific neural pathways can regulate different types of feeding behavior, driven by either hunger or non-hunger cues.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Sayaka Hori, Shohei Mitani
Summary: The transcription factor unc-130 plays a crucial role in optimizing avoidance behavior in Caenorhabditis elegans by regulating the expression of multiple genes. It acts in parallel molecular pathways with other genes to establish specific neuronal identities for avoidance optimization.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Xiuping Fu, Aparna P. Shah, Jacqueline Keighron, Ta-Chung M. Mou, Bruce Ladenheim, Jesse Alt, Daisuke Fukudome, Minae Niwa, Kellie L. Tamashiro, Gianluigi Tanda, Akira Sawa, Jean-Lud Cadet, Rana Rais, Jay M. Baraban
Summary: The study found that mice lacking the microRNA-degrading enzyme showed an exaggerated locomotor response to amphetamine and had higher brain levels of the drug, which correlated with adiposity. Diet-induced increases in adiposity also led to elevated brain levels of amphetamine in wild type mice.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, Hannah N. Saeger, John D. McCorvy, John A. Gray, Lin Tian, David E. Olson
Summary: Decreased dendritic spine density in the cortex is a common feature of neuropsychiatric diseases, and psychedelics have been found to promote cortical neuron growth. This study shows that intracellular 5-HT2A receptors mediate the plasticity-promoting effects of psychedelics, providing insight into the mechanisms behind their therapeutic effects. The findings suggest that targeting intracellular 5-HT2A receptors could be a potential therapeutic approach.
Article
Multidisciplinary Sciences
Sonali A. Deshpande, Ethan W. Rohrbach, James D. Asuncion, Jenna Harrigan, Aditya Eamani, Ellery H. Schlingmann, Daniel J. Suto, Pei-Tseng Lee, Felix E. Schweizer, Hugo J. Bellen, David E. Krantz
Summary: Octopamine plays an essential role in egg-laying in Drosophila melanogaster. This study identifies two octopamine receptors, Oct beta 2 and OAMB, that regulate oviduct contraction and relaxation, respectively. The interaction with glutamatergic pathways modifies the effects of octopamine, suggesting a possible mechanism for lateral oviduct contractions. The aminergic pathways in the oviposition circuit may be comparable to those that regulate visceral muscle contractility in mammals.
Article
Neurosciences
Mark A. Rossi, Marcus L. Basiri, Yuejia Liu, Yoshiko Hashikawa, Koichi Hashikawa, Lief E. Fenno, Yoon Seok Kim, Charu Ramakrishnan, Karl Deisseroth, Garret D. Stuber
Summary: The lateral hypothalamic area (LHA) contains distinct populations of glutamatergic neurons that project to different brain regions, with neurons projecting to the lateral habenula (LHb) or ventral tegmental area (VTA) showing anatomical, transcriptional, electrophysiological, and functional differences. Neurons projecting to the LHb are particularly sensitive to satiety state and feeding hormones, indicating differential processing of reward and aversion stimuli in divergent efferent pathways.
Article
Neurosciences
Renchao Chen, Timothy R. Blosser, Mohamed N. Djekidel, Junjie Hao, Aritra Bhattacherjee, Wenqiang Chen, Luis M. Tuesta, Xiaowei Zhuang, Yi Zhang
Summary: The authors utilized single-cell RNA sequencing and multiplexed error-robust FISH to generate a cell census of the mouse nucleus accumbens, revealing a high level of cell heterogeneity. This study demonstrates that the transcriptional and spatial diversity of neuron subtypes underlie the anatomic and functional heterogeneity of the nucleus accumbens.
NATURE NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jaspreet Kaur, Rune W. Berg
Summary: Targeting specific subtypes of interneurons in the spinal cord is often limited to a small group of genetic model animals. However, using adeno-associated virus (AAV) to deliver endogenous enhancers and promoters has shown promise in expressing specific subtypes of neurons in the forebrain of wild-type animals. This study tested the specificity and efficiency of the mDlx enhancer in targeting inhibitory interneurons in the lumbar spinal cord of wild-type rats using AAV serotype 2 (AAV2), as well as the expression and specificity of the CamKIIa and hSynapsin promoters using AAV serotype 9 (AAV9).
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Antonio Fernandez-Perez, Adrian Sanz-Magro, Rosario Moratalla, Mario Vallejo
Summary: This response addresses the concerns raised by Scarpa et al. (2022) regarding the previous research findings and provides further analysis and additional results to support the original conclusions.
Article
Cell Biology
Song Cai, Aubin Moutal, Jie Yu, Lindsey A. Chew, Jorg Isensee, Reena Chawla, Kimberly Gomez, Shizhen Luo, Yuan Zhou, Aude Chefdeville, Cynthia Madura, Samantha Perez-Miller, Shreya Sai Bellampalli, Angie Dorame, David D. Scott, Liberty Francois-Moutal, Zhiming Shan, Taylor Woodward, Vijay Gokhale, Andrea G. Hohmann, Todd W. Vanderah, Marcel Patek, May Khanna, Tim Hucho, Rajesh Khanna
Summary: Blocking SUMO modification on CRMP2 can inhibit NaV1.7 function and provide analgesic effects in rodents. Compound 194, a first-in-class protein-protein inhibitor targeting CRMP2-NaV1.7 regulation, shows analgesic effects in acute and chronic pain models.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Jianzhi Zeng, Xuelin Li, Renzimo Zhang, Mingyue Lv, Yipan Wang, Ke Tan, Xiju Xia, Jinxia Wan, Miao Jing, Xiuning Zhang, Yu Li, Yang Yang, Liang Wang, Jun Chu, Yan Li, Yulong Li
Summary: This study found that dopamine bi-directionally regulates the temporal window of olfactory learning in Drosophila and affects the synaptic plasticity of Kenyon cells in the mushroom body. The release of acetylcholine by KCs activates the serotonergic DPM neuron, which provides inhibitory feedback to KCs. The study also discovered that 5-HT signals have spatial heterogeneity in the mushroom body and can proportionally gate the coincidence time windows of different compartments.
Article
Neurosciences
Deena M. Walker, Margaret R. Bell, Cecilia Flores, Joshua M. Gulley, Jari Willing, Matthew J. Paul
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Santiago Cuesta, Jose Maria Restrepo-Lozano, Steven Silvestrin, Dominique Nouel, Angelica Torres-Berrio, Lauren M. Reynolds, Andreas Arvanitogiannis, Cecilia Flores
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Lauren M. Reynolds, Matthew Pokinko, Angelica Torres-Berrio, Santiago Cuesta, Laura C. Lambert, Esther Del Cid Pellitero, Michael Wodzinski, Colleen Manitt, Paul Krimpenfort, Bryan Kolb, Cecilia Flores
BIOLOGICAL PSYCHIATRY
(2018)
Article
Neurosciences
Daniel E. Vosberg, Yu Zhang, Aurore Menegaux, Amanda Chalupa, Colleen Manitt, Simone Zehntner, Conrad Eng, Kristina DeDuck, Dominique Allard, France Durand, Alain Dagher, Chawki Benkelfat, Myriam Srour, Ridha Joober, Franco Lepore, Guy Rouleau, Hugo Theoret, Barry J. Bedell, Cecilia Flores, Marco Leyton
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Lauren M. Reynolds, Leora Yetnikoff, Matthew Pokinko, Michael Wodzinski, Julia G. Epelbaum, Laura C. Lambert, Marie-Pierre Cossette, Andreas Arvanitogiannis, Cecilia Flores
Article
Clinical Neurology
Daniel E. Vosberg, Vincent Beaule, Angelica Torres-Berrio, Danielle Cooke, Amanda Chalupa, Natalia Jaworska, Sylvia M. L. Cox, Kevin Larcher, Yu Zhang, Dominique Allard, France Durand, Alain Dagher, Chawki Benkelfat, Myriam Srour, Donatella Tampieri, Roberta La Piana, Ridha Joober, Franco Lepore, Guy Rouleau, Alvaro Pascual-Leone, Michael D. Fox, Cecilia Flores, Marco Leyton, Hugo Theoret
ANNALS OF NEUROLOGY
(2019)
Editorial Material
Neurosciences
Lauren M. Reynolds, Cecilia Flores
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Angelica Torres-Berrio, Dominique Nouel, Santiago Cuesta, Eric M. Parise, Jose Maria Restrepo-Lozano, Pier Larochelle, Eric J. Nestler, Cecilia Flores
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Santiago Cuesta, Jose Maria Restrepo-Lozano, Christina Popescu, Susan He, Lauren M. Reynolds, Sonia Israel, Giovanni Hernandez, Rana Rais, Barbara S. Slusher, Cecilia Flores
Article
Biochemistry & Molecular Biology
Daniel E. Vosberg, Marco Leyton, Cecilia Flores
MOLECULAR PSYCHIATRY
(2020)
Review
Neurosciences
Angelica Torres-Berrio, Giovanni Hernandez, Eric J. Nestler, Cecilia Flores
BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Angelica Torres-Berrio, Alice Morgunova, Michel Giroux, Santiago Cuesta, Eric J. Nestler, Cecilia Flores
Summary: miR-218 expression in adolescence may serve as both a marker of risk and a target for early interventions in stress vulnerabilities, as it regulates Dcc expression and correlates with social defeat stress vulnerability in adulthood in male mice.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Samer Salameh, Dominique Nouel, Cecilia Flores, Daniel Hoops
Article
Neurosciences
Daniel Hoops, Lauren M. Reynolds, Jose-Maria Restrepo-Lozano, Cecilia Flores
Article
Neurosciences
Angelica Torres-Berrio, Juan Pablo Lopez, Rosemary C. Bagot, Dominique Nouel, Gregory Dal Bo, Santiago Cuesta, Lei Zhu, Colleen Manitt, Conrad Eng, Helen M. Cooper, Kai-Florian Storch, Gustavo Turecki, Eric J. Nestler, Cecilia Flores
BIOLOGICAL PSYCHIATRY
(2017)