期刊
MOLECULAR PSYCHIATRY
卷 25, 期 2, 页码 297-307出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41380-019-0561-7
关键词
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资金
- National Institute on Drug Abuse [R01DA037911]
- Natural Science and Engineering Research Council of Canada [2982226]
- Canadian Institutes of Health Research [MOP-119543, 133537, 152910, MOP-74709, 119543]
- Le Fonds de recherche du Quebec - Sante (FRQS)
- McGill University Faculty of Medicine Internal Studentship Awards (Hugh E. Burke Fellowship)
- McGill University Faculty of Medicine Internal Studentship Awards (James O. and Maria Meadows Fellowship)
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA037911] Funding Source: NIH RePORTER
Axon guidance molecules direct growing axons toward their targets, assembling the intricate wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC (deleted in colorectal cancer), has profound effects, in laboratory animals, on the adolescent expansion of mesocorticolimbic pathways, particularly dopamine. Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use. Together, these findings provide compelling evidence that Netrin-1 and DCC influence mesocorticolimbic-related psychopathological states that emerge during adolescence.
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