Article
Multidisciplinary Sciences
Claudina Kwok, Kelly Lei, Vincent Pedrozo, Lexy Anderson, Shahbaj Ghotra, Margaret Walsh, Laura Li, JiHwan Yu, Frederic Woodward Hopf
Summary: The study found that Ox1Rs in the shell drive drinking behavior in males but not in females. On the other hand, systemic Ox1R inhibition can reduce compulsive drinking in both sexes, while higher doses of inhibition reduce binge drinking in both sexes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Kyle D. Ketchesin, Darius D. Becker-Krail, Xiangning Xue, Rashaun S. Wilson, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn, George C. Tseng, Ryan W. Logan
Summary: Substance use disorders disrupt sleep and circadian rhythms, increasing the risk of relapse. This study investigates the effects of cocaine and morphine on the diurnal rhythms of proteome in the nucleus accumbens (NAc), a key brain region for reward and motivation. The results show that cocaine and morphine differentially alter proteome diurnal rhythms in the NAc, with distinct proteins expressed at different times of the day. Cocaine altered proteins related to glucocorticoid signaling and metabolism, while morphine was associated with neuroinflammation. These findings provide insights into the regulation of NAc proteome and the differential effects of cocaine and morphine.
JOURNAL OF PROTEOME RESEARCH
(2023)
Editorial Material
Biochemistry & Molecular Biology
Amrita R. Nair, Steve W. C. Chang
Summary: This study further explores the role of oxytocin in maintaining social relationships and its interaction with the endocannabinoid system.
Article
Endocrinology & Metabolism
Georgia E. Kirkpatrick, Paige M. Dingess, Jake A. Aadland, Travis E. Brown
Summary: This study investigates whether forced exercise can attenuate the incubation of high-fat food craving. The results suggest that high-intensity exercise can prevent the establishment of incubation of craving for high-fat foods and may reduce cue-induced maladaptive food-seeking behaviors.
Article
Neurosciences
Kelle E. Nett, Alexa R. Zimbelman, Matthew S. McGregor, Vanessa Alizo Vera, Molly R. Harris, Ryan T. LaLumiere
Summary: Previous evidence suggests that the infralimbic cortex (IL) plays a role in inhibiting cocaine seeking behavior in rats. In this study, the researchers investigated whether IL activity and its outputs to the nucleus accumbens shell (NAshell) and amygdala are involved in encoding extinction contingencies following cocaine self-administration. They used optogenetic techniques to silence IL-NAshell or IL-amygdala activity after an unreinforced lever press during extinction training and found that inhibition of IL-NAshell or IL-amygdala activity impaired extinction retention.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Lieke L. van de Haar, Danai Riga, Juliska E. Boer, Oxana Garritsen, Youri Adolfs, Thomas E. Sieburgh, Roland E. van Dijk, Kyoko Watanabe, Nicky C. H. van Kronenburg, Mark H. Broekhoven, Danielle Posthuma, Frank J. Meye, Onur Basak, R. Jeroen Pasterkamp
Summary: This study reveals the cellular and molecular trajectories of habenular neuron development and organization into subtypes, as well as their distinctive functional properties and projection targets. It also links specific developing habenular subtypes to psychiatric disease, providing a framework for further investigation of habenular development in normal and disease states.
Article
Multidisciplinary Sciences
Marco D. Carpenter, Delaney K. Fischer, Shuo Zhang, Allison M. Bond, Kyle S. Czarnecki, Morgan T. Woolf, Hongjun Song, Elizabeth A. Heller
Summary: The authors optimized a hybrid protocol, ICuRuS, to profile epigenetic features in neuronal subtypes from a single mouse. This method allows for robust epigenetic profiling at cell-type specific resolution.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Darius D. Becker-Krail, Puja K. Parekh, Kyle D. Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A. Hildebrand, Brandon Dunham, Madhavi K. Ganapathiraiu, Ryan W. Logan, Colleen A. McClung
Summary: Substance use disorders are associated with disruptions to both circadian rhythms and cellular metabolic state, which may be interconnected through the interactions with SIRT1. In the nucleus accumbens, NPAS2 and SIRT1 play roles in reward-related pathways and are regulated by NAD(+). The interaction between NPAS2 and SIRT1 in the NAc may integrate cocaine's effects on circadian and metabolic factors, ultimately regulating drug reward.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yang Li, Liang Qu, Nan Li, Xin Wang, Ping Wang, Shun-nan Ge, Xue-lian Wang
Summary: The study aimed to improve the success rate of rat jugular vein catheterization and the self-administration (SA) model through an optimized scheme. The results showed that the success rate in the optimized operation group was significantly higher than the traditional operation group. The optimized scheme made various improvements in materials and techniques, providing a more stable and efficient tool for basic research on drug addiction.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Shaoqiang Han, Ruiping Zheng, Shuying Li, Bingqian Zhou, Yu Jiang, Keke Fang, Yarui Wei, Baohong Wen, Jianyue Pang, Hengfen Li, Yong Zhang, Yuan Chen, Jingliang Cheng
Summary: This study aimed to investigate the altered structural covariance of nucleus accumbens (NAcc) in never-treated first-episode patients with depression and how it was modulated by illness duration and severity of symptom. The results revealed that patients with depression exhibited abnormal structural covariance of NAcc connected to key brain regions in the reward system, and this abnormality was distinctly modulated by illness duration and the severity of symptom.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Avishay Dolitzky, Guy Shapira, Sharon Grisaru-Tal, Inbal Hazut, Shmulik Avlas, Yaara Gordon, Micahl Itan, Noam Shomron, Ariel Munitz
Summary: Eosinophils are multifunctional leukocytes involved in regulating tissue homeostasis, host defense, and cancer responses. They can respond to both Type 1 and Type 2 inflammatory stimuli based on recent RNA sequencing data, exhibiting distinct transcription profiles. These findings suggest that eosinophils exhibit heterogeneity and transcriptional differences between Type 1 and Type 2 cells, influencing their diverse activities in various disease settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Parth Bhatia, Lite Yang, Jay X. J. Luo, Mengyi Xu, William Renthal
Summary: In this study, the researchers used snATAC-seq to map cell-type-specific differences in chromatin accessibility in the NAc. They identified transcription factors and putative gene regulatory regions that might contribute to these differences and provided a valuable resource for future studies on epigenomic changes in neuropsychiatric disorders.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Felix P. Mayer, Hideki Iwamoto, Maureen K. Hahn, Gregory J. Grumbar, Adele Stewart, Yulong Li, Randy D. Blakely
Summary: The study demonstrates that moving animals from a recording chamber back to a familiar or clean cage triggers dopamine release, showing a similar effect to cocaine injection in the recording chamber. This suggests that returning to a home-like environment can result in DA release, indicating a rewarding stimulus. The findings provide insights into the reward circuitry and offer potential for studying anhedonic states and developing new treatments for mood disorders.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Cell Biology
Wenjie Zou, Zhipeng Guo, Longge Suo, Jianping Zhu, Haiyang He, Xiufeng Li, Kewan Wang, Rongqing Chen
Summary: The study revealed that the NAc shell and its D1R-MSN or D2R-MSN play crucial roles in the propagation and generalization of TLE seizures. Pharmacological or cell-type-specific chemogenetic inhibition of the NAc shell can alleviate TLE seizures by reducing the number of generalized seizures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Cassandra L. Retzlaff, Patrick E. Rothwell
Summary: This study is the first to examine the physiological properties of neuropeptide Y interneurons in the nucleus accumbens and shows that activation of mu opioid receptors inhibits the activity of low-threshold spiking interneurons and reduces GABA release onto medium spiny neurons.
Article
Engineering, Industrial
Amrites Senapati, Ashis Bhattacherjee, Snehamoy Chatterjee
Summary: This study examines risk factors influencing human error in underground continuous miner worksites and finds injury occurrences are associated with a range of personal factors and poor work organization. The Bootstrap integrated conditional logistic regression model provided efficient results for the small sample size and collinearity seen in the dataset. Addressing these multifactorial issues through appropriate prevention programs would result in a safer workplace.
Article
Multidisciplinary Sciences
Yuen Gao, Natalia Duque-Wilckens, Mohammad B. Aljazi, Adam J. Moeser, George I. Mias, Alfred J. Robison, Yi Zhang, Jin He
Summary: Recent clinical studies have shown that chromosomal 12q24.31 microdeletions are associated with autism spectrum disorder (ASD) and intellectual disability (ID). This study reveals that the gene Kdm2b, located in the chromosomal region 12q24.31, plays a critical role in maintaining neural stem cells in the mouse brain. Additionally, the Kdm2b mutation is found to induce ASD/ID-like behavioral and memory deficits.
Article
Public, Environmental & Occupational Health
Rahul Upadhyay, Ashis Bhattacherjee, Aditya Kumar Patra, Nearkasen Chau
Summary: The study found that dumper operators in mines are exposed to high levels of vibration which adversely affects their musculoskeletal system, especially leading to issues such as upper back pain, lower back pain, knee and leg pain. Dumper operators of older age have a higher risk of MSD pains.
WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
(2022)
Article
Cell Biology
Zhenfei Xie, Wenhao Zhang, Yi Zhang
Summary: Placenta hyperplasia is a common issue in cloned animals and negatively affects the development of cloned embryos. The underlying mechanism behind this phenomenon is largely unknown. In this study, the authors found that placenta hyperplasia occurs in both middle and late gestation in cloned mouse embryos. They further discovered that restoring the expression of a specific amino acid transporter, Slc38a4, can rescue the overgrowth of cloned placentae in late gestation. Molecular analyses revealed that loss of Slc38a4 imprinting leads to over-activation of the mTORC1 signaling pathway, likely due to increased amino acid transport. The findings suggest that loss of Slc38a4 imprinting is responsible for the overgrowth of cloned placentae, and the underlying mechanism involves increased amino acid transport and over-activation of mTORC1.
Article
Ergonomics
Rahul Upadhyay, Amrites Senapati, Kenora Chau, Ashis Bhattacherjee, Aditya Kumar Patra, Nearkasen Chau
Summary: Studies on intervention design to reduce whole-body vibration (WBV) exposure are limited. This study proposes a systematic approach to identify, select, and prioritize safety interventions. Vibration readings were collected from 130 dumper operators in surface iron ore mines to identify significant determinants of WBV exposure.
INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
(2023)
Article
Materials Science, Multidisciplinary
S. Kundu, T. Sarkar, G. Ghorai, M. Zubko, P. K. Sahoo, M. Weselski, V. Raghavendra Reddy, A. Bhattacharjee
Summary: We investigated the solventless synthesis of iron oxide nanomaterials by thermally converting iron(III)citrate in the presence of malonic acid and glucose as co-precursors. The physical characterization of the synthesized materials showed that pure hematite phase was obtained only under specific conditions, while a mixture of hematite and magnetite was obtained in other cases. The co-precursors had a significant effect on the nature and size of the synthesized materials, with an increasing amount leading to a gradual conversion of hematite to magnetite.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Nanoscience & Nanotechnology
Toton Sarkar, Sani Kundu, Gurupada Ghorai, Pratap Kumar Sahoo, Ashis Bhattacharjee
Summary: ZnO nanoparticles were synthesized using Tabernaemontana divaricata flower extract and their structure and properties were studied. The crystals formed are of hexagonal wurtzite structure with biological functional groups attached. The size and defect density of the nanoparticles showed opposite trends with increasing amount of flower extract. The optical energy band gap values decreased with increasing amount of flower extract. FESEM study showed agglomerated nanoparticles with quasi-spherical morphology. EDX and HRTEM study revealed the chemical composition and crystal morphology of the nanoparticles. The study demonstrated the significant impact of flower extract on the structure and properties of ZnO nanoparticles.
ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Sani Kundu, Toton Sarkar, Ashis Bhattacharjee
Summary: Hematite nanomaterials were synthesized by thermal decomposition of different precursors, and the dielectric properties and conduction mechanisms were studied. The hematite nanomaterials exhibited particle-size-dependent high dielectric constant, highlighting their potential for applications.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Letter
Engineering, Chemical
Ashis Bhattacharjee India
Summary: This Letter to the Editor addresses significant concerns regarding the data analysis and conclusions presented in the article 'A novel approach for determination of nucleation rates and interfacial energy of metallic magnesium nanoclusters at high temperature using non-isothermal TGA models' by P. Srivastava et al. published in Chemical Engineering Science 265 (2023), 11822.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Chemistry, Physical
Sani Kundu, Manisha Chakraborty, Ashis Bhattacharjee
Summary: This article investigates the thermal decomposition of ferrocene in the presence of oxalic acid dihydrate in oxidative and inert atmospheres. The experimental results show that hematite and cohenite nanomaterials can be synthesized through the thermal decomposition of a mixture of ferrocene and oxalic acid dihydrate in O-2 and N-2 atmospheres, respectively. The reaction steps involved in these decompositions are complex and can be separated using a peak deconvolution method. The kinetic and thermodynamic parameters are estimated, and the effect of the reaction atmosphere on the thermal decomposition process of ferrocene is realized.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Thermodynamics
Manisha Chakraborty, Sani Kundu, Bratati Das, Ashis Bhattacharjee
Summary: By conducting experiments and characterizing the decomposed materials, this study convincingly establishes the significant effect of the reaction atmosphere on the thermal decomposition of an organo-iron compound as well as the nature of the material produced.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Neurosciences
Aritra Bhattacherjee, Chao Zhang, Brianna R. Watson, Mohamed Nadhir Djekidel, Jeffrey R. Moffitt, Yi Zhang
Summary: The prefrontal cortex (PFC) shows distinct cellular and molecular features, as well as circuit organization, which are associated with its diverse functions. This study provides insights into the specific mechanisms underlying PFC functions, including chronic pain.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Yurika Matsui, Mohamed Nadhir Djekidel, Katherine Lindsay, Parimal Samir, Nina Connolly, Gang Wu, Xiaoyang Yang, Yiping Fan, Beisi Xu, Jamy C. Peng
Summary: The study shows that SNIP1 is critical for the survival and differentiation of stem cells in the developing brain. It regulates PRC2 activities downstream of TGFb and NFkB, influencing cell fates. Understanding the role of SNIP1 in brain development can provide insights into cell survival and death during development.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Judith Hyle, Mohamed Nadhir Djekidel, Justin Williams, Shaela Wright, Ying Shao, Beisi Xu, Chunliang Li
Summary: This study employs the AID2 technology to investigate the role of CTCF in transcriptional regulation. The zinc finger domains in CTCF are found to be the most functionally relevant, and each domain has unique functions in DNA binding and transcriptional regulation. A model is created to explain how CTCF orchestrates transcriptional regulation in a cellular context.
Article
Chemistry, Multidisciplinary
Manisha Chakraborty, Sani Kundu, Ashis Bhattacharjee
Summary: The thermal decomposition of a mixture of ferrocene carboxaldehyde and oxalic acid dihydrate in an O2 atmosphere produces rod-like hematite nanomaterials. The study demonstrates the importance of a co-precursor in enhancing the reaction and provides insights into the reaction mechanism and thermodynamic parameters. The findings have significant implications for the synthesis of iron-based nanoparticles and understanding decomposition reactions.