Article
Medicine, Research & Experimental
Eri Kawashita, Takeyoshi Ozaki, Keiichi Ishihara, Chihiro Kashiwada, Satoshi Akiba
Summary: The cell-type specific deficiency of IVA-PLA(2) in endothelial cells/liver sinusoidal endothelial cells (EC/LSEC) appears to play a critical role in the onset and progression of NASH, making it a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren
Summary: This study discovered that cysteine sulfinic acid decarboxylase (CSAD) expression significantly decreased in non-alcoholic fatty liver disease (NAFLD) patients, which was confirmed in multiple NAFLD mouse models. The overexpression of CSAD in the liver of high-fat diet-fed mice alleviated NAFLD-associated pathologies and increased the expression of fatty acid beta-oxidation genes. CSAD was also found to improve mitochondrial injury. These findings suggest that CSAD has the potential to become a new therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masaya Koganesawa, Munehiro Yamaguchi, Sachin K. Samuchiwal, Barbara Balestrieri
Summary: Macrophages activated by IL-4 (M2) or LPS+IFN gamma (M1) have distinct lipid metabolism profiles, with Pla2g5 playing a key role in this process. Pla2g5 is involved in phospholipid metabolism and eicosanoid production in both types of activated macrophages.
Article
Biochemistry & Molecular Biology
Mona Alonazi, Aida Karray, Raida Jallouli, Abir Ben Bacha
Summary: This study reported the biochemical and enzymatic characteristics of PLA(2)-V from dromedary, as well as its antimicrobial and cytotoxic effects.
Article
Pharmacology & Pharmacy
Takeyoshi Ozaki, Eri Kawashita, Keiichi Ishihara, Satoshi Akiba
Summary: Hepatic fibrosis, a common feature of non-alcoholic steatohepatitis (NASH), is characterized by the activation of hepatic stellate cells (HSCs). In this study, we investigated the potential therapeutic effect of inhibiting group IVA phospholipase A(2) (IVA-PLA(2)) on hepatic fibrosis in NASH using knockout mice. Our results showed that deficiency of IVA-PLA(2) in collagen-producing cells alleviated the progression of hepatic fibrosis under dietary modification. This suggests that targeting IVA-PLA(2) may be a promising strategy for treating progressive hepatic fibrosis in NASH.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Review
Pharmacology & Pharmacy
Makoto Murakami
Summary: Phospholipase A2 (PLA2) is a group of enzymes that release fatty acids and lysophospholipids from glycerophospholipids. They have been implicated in signal transduction, membrane homeostasis, energy production, and lipid pathway regulation. Perturbation of PLA2-driven lipid pathways may be associated with various diseases. This review discusses the physiological functions of the PLA2 superfamily, focusing on different PLA2 families and their roles in lipid metabolism.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Shulin Hou, Junping Bai, Chunting Chen, Xiaozheng Zhang, Fangyuan Chang, Zhihua Cao, Tingting Xu, Jun Xie
Summary: sPLA2s are calcium-dependent enzymes involved in lipid metabolism and inflammation. Research shows that flexibly bound Ca2 is essential for the catalysis of hGIIE, contrasting with the stable binding of Ca2 in hGIIA.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Luyiyun Liang, Rina Takamiya, Yoshimi Miki, Kanako Heike, Yoshitaka Taketomi, Nao Sugimoto, Midori Yamaguchi, Hiroshi Shitara, Yasumasa Nishito, Tetsuyuki Kobayashi, Tetsuya Hirabayashi, Makoto Murakami
Summary: The study reveals that cPLA2epsilon plays a counterregulatory role in psoriatic inflammation by promoting the biosynthesis of anti-inflammatory lipid N-acylethanolamine (NAE). The findings provide important insights into the regulation of inflammation in psoriasis.
Article
Biochemistry & Molecular Biology
Chutima Jansakun, Warangkana Chunglok, Sandro Altamura, Martina Muckenthaler, Simone Staffer, Sabine Tuma-Kellner, Uta Merle, Walee Chamulitrat
Summary: Polymorphisms of iPLA2 beta/PLA2G6 are associated with body weights and blood C-reactive protein. In this study, mice with myeloid-specific and hepatocyte-specific PLA2G6 deletion were generated and phenotyped after feeding with a specific diet. Myeloid-specific deletion led to aggravation of liver inflammation and fibrosis, while hepatocyte-specific deletion provided complete protection and attenuated expression of fatty-acid uptake and lipogenesis genes. These findings suggest that PLA2G6 inactivation in specific cells plays a role in the development of non-alcoholic steatohepatitis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Yoshitaka Taketomi, Yoshimi Miki, Makoto Murakami
Summary: The sPLA(2) family is a group of enzymes with unique tissue or cellular distributions and functions that exert their effects through hydrolysis of extracellular phospholipids. Recent studies have found that sPLA(2)-IIA can act as a modulator of the gut microbiota, affecting intestinal inflammation, allergy, and cancer. These studies reveal a connection between the gut microbiota and systemic homeostasis and diseases.
Article
Cell Biology
Maria Mangini, Rosa D'Angelo, Caterina Vinciguerra, Christine Payre, Gerard Lambeau, Barbara Balestrieri, Julia F. F. Charles, Stefania Mariggio
Summary: This study investigates the role of group IIA secreted phospholipase A(2) (sPLA(2)-IIA) in osteoclast bone-resorption activity and syncytium formation. The results suggest that sPLA(2)-IIA is involved in the regulation of osteoclast maturation and fusion through both catalytic-dependent and independent mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Qian Zou, Meng Wei, Niu Zhang, Xian Niu, Chen Weng, Ze-Yuan Deng, Jing Li
Summary: This study found that 9t18:1 had a greater damaging effect on normal human hepatocyte function compared to 11t18:1 and 9t16:1, with different mixtures of fatty acids also showing varying degrees of harm. Lipidomics results indicated that TFAs and their mixtures induced significant changes in the lipid profiles of cells, leading to increased contents of specific lipid categories.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Nives Bogataj Jontez, Sasa Kenig, Karin Sik Novak, Ana Petelin, Zala Jenko Praznikar, Nina Mohorko
Summary: This study compared the dietary patterns of individuals following LCHF, vegan, vegetarian, and omnivorous diets. The results showed that compared to other groups, the LCHF group had higher intakes of saturated fats, cholesterol, and animal proteins, while the intakes of sugars and dietary fibers were lower. The levels of total and LDL cholesterol were significantly higher in the LCHF group. Thus, it is recommended to select healthy fat sources, increase dietary fiber intake, and partially replace animal sources with plant sources in the LCHF diet.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Aladahalli S. Giresha, Deepadarshan Urs, Sophiya Pundalik, Rajkumar S. Meti, Siddanakoppalu N. Pramod, Ballenahalli H. Supreetha, Madhusudana Somegowda, Kattepura K. Dharmappa, Ahmed M. El-Shehawi, Sarah Albogami, Mona M. Elseehy, Abdullah Alaklabi, Hosam O. Elansary, Alanoud Omur A. Mehder, Eman A. Mahmoud
Summary: The study evaluated the antioxidant molecule sinapic acid for its ability to inhibit sPLA(2)-IIA as an anti-inflammatory agent. Sinapic acid showed strong antioxidant potency and significantly reduced sPLA(2)-IIA activity, hemolytic activity, and mouse paw edema, demonstrating its anti-inflammatory and anti-hemorrhagic effects.
Article
Oncology
Upasana Ray, Debarshi Roy, Ling Jin, Prabhu Thirusangu, Julie Staub, Yinan Xiao, Eleftheria Kalogera, Andrea E. Wahner Hendrickson, Grace D. Cullen, Krista Goergen, Ann L. Oberg, Viji Shridhar
Summary: The study demonstrates that downregulation of PLA2G3 inhibits lipid droplet biogenesis, reduces cell growth, and increases sensitivity to platinum drugs in ovarian cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hiroki Otani, Hiromasa Yamamoto, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka
Article
Cell Biology
Shinji Hatakeyama, Serge Summermatter, Marie Jourdain, Stefan Melly, Giulia C. Minetti, Estelle Lach-Trifilieff
Article
Multidisciplinary Sciences
Marco Segatto, Raffaella Fittipaldi, Fabrizio Pin, Roberta Sartori, Kyung Dae Ko, Hossein Zare, Claudio Fenizia, Gianpietro Zanchettin, Elisa Sefora Pierobon, Shinji Hatakeyama, Cosimo Sperti, Stefano Merigliano, Marco Sandri, Panagis Filippakopoulos, Paola Costelli, Vittorio Sartorelli, Giuseppina Caretti
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Marie Jourdain, Stefan Melly, Serge Summermatter, Shinji Hatakeyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Brigitte Fournier, Ben Murray, Sabine Gutzwiller, Stefan Marcaletti, David Marcellin, Sebastian Bergling, Sophie Brachat, Elke Persohn, Eliane Pierrel, Florian Bombard, Shinji Hatakeyama, Anne-Ulrike Trendelenburg, Frederic Morvan, Brian Richardson, David J. Glass, Estelle Lach-Trifilieff, Jerome N. Feige
MOLECULAR AND CELLULAR BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Estelle Lach-Trifilieff, Giulia C. Minetti, KellyAnn Sheppard, Chikwendu Ibebunjo, Jerome N. Feige, Steffen Hartmann, Sophie Brachat, Helene Rivet, Claudia Koelbing, Frederic Morvan, Shinji Hatakeyama, David J. Glass
MOLECULAR AND CELLULAR BIOLOGY
(2014)
Meeting Abstract
Clinical Neurology
C. Lambert, J. Boesch, M. Obrecht, J. Grosjean, P. R. Allegrini, S. Hatakeyama
NEUROMUSCULAR DISORDERS
(2014)
Article
Multidisciplinary Sciences
Neil Johns, Shinji Hatakeyama, Nathan A. Stephens, Martin Degen, Simone Degen, Wilfried Frieauff, Christian Lambert, James A. Ross, Ronenn Roubenoff, David J. Glass, Carsten Jacobi, Kenneth C. H. Fearon
Article
Multidisciplinary Sciences
Kristine Pettersen, Sonja Andersen, Simone Degen, Valentina Tadini, Joel Grosjean, Shinji Hatakeyama, Almaz N. Tesfahun, Siver Moestue, Jana Kim, Unni Nonstad, Pal R. Romundstad, Frank Skorpen, Sveinung Sorhaug, Tore Amundsen, Bjorn H. Gronberg, Florian Strasser, Nathan Stephens, Dag Hoem, Anders Molven, Stein Kaasa, Kenneth Fearon, Carsten Jacobi, Geir Bjorkoy
SCIENTIFIC REPORTS
(2017)
Article
Pharmacology & Pharmacy
Magdalena Koziczak-Holbro, Dean F. Rigel, Berengere Dumotier, David A. Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bosch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moise Azria, Robin A. Fairhurst, Steven J. Charlton, Brian P. Richardson, Estelle Lach-Trifilieff, David J. Glass, Thomas Ullrich, Shinji Hatakeyama
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Chie Koshiishi, Takanori Kanazawa, Eric Vangrevelinghe, Toshiyuki Honda, Shinji Hatakeyama
Article
Biology
Marie Jourdain, Shinji Hatakeyama
BMC RESEARCH NOTES
(2019)
Article
Biology
Shigemi Fukami, Daisaku Tomioka, Yutaka Murakami, Toshiyuki Honda, Shinji Hatakeyama
BMC RESEARCH NOTES
(2019)
Article
Biology
Takeshi Yamaura, Tatsuhiko Kasaoka, Naoko Iijima, Masaaki Kimura, Shinji Hatakeyama
BMC RESEARCH NOTES
(2019)
Meeting Abstract
Oncology
Hiromasa Yamamoto, Hiroki Otani, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka
JOURNAL OF THORACIC ONCOLOGY
(2015)