An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential

(2013) H.Q. Han et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Disuse-induced muscle wasting

(2013) Sue C. Bodine   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genomic Profiling Reveals That Transient Adipogenic Activation Is a Hallmark of Mouse Models of Skeletal Muscle Regeneration

(2013) Laura Lukjanenko et al.   PLoS One

The central role of myostatin in skeletal muscle and whole body homeostasis

(2012) B. Elliott et al.   Acta Physiologica

Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; no alterations post-lenalidomide and dexamethasone therapy

(2012) E. Terpos et al.   ANNALS OF ONCOLOGY

Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells

(2012) M A Hoda et al.   BRITISH JOURNAL OF CANCER

Sarcopenia in the elderly

(2012) J. E. Morley   FAMILY PRACTICE

Genomic and Proteomic Profiling Reveals Reduced Mitochondrial Function and Disruption of the Neuromuscular Junction Driving Rat Sarcopenia

(2012) C. Ibebunjo et al.   MOLECULAR AND CELLULAR BIOLOGY

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

A single ascending-dose study of muscle regulator ace-031 in healthy volunteers

(2012) Kenneth M. Attie et al.   MUSCLE & NERVE

TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A

(2012) Anne Trendelenburg et al.   Skeletal Muscle

Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1

(2011) Cécile Polge et al.   FASEB JOURNAL

Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance

(2011) Sílvia Busquets et al.   Journal of Cachexia Sarcopenia and Muscle

Recent advances in the biology and therapy of muscle wasting

(2010) David Glass et al.   Annals of the New York Academy of Sciences

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Regulation of Muscle Mass by Follistatin and Activins

(2010) Se-Jin Lee et al.   MOLECULAR ENDOCRINOLOGY

Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition

(2010) Marcus D. Goncalves et al.   PLoS One

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Redundancy of myostatin and growth/differentiation factor 11 function

(2009) Alexandra C McPherron et al.   BMC DEVELOPMENTAL BIOLOGY

Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor   Production and Protects Liver Against Obesity-Induced Insulin Resistance

(2009) J. J. Wilkes et al.   DIABETES

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

(2009) I Akpan et al.   INTERNATIONAL JOURNAL OF OBESITY

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration

(2009) Kishore M. Lakshman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Administration of a mutated myostatin propeptide to neonatal mice significantly enhances skeletal muscle growth

(2009) Zicong Li et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators

(2008) Tatyana A. Souza et al.   MOLECULAR ENDOCRINOLOGY