Article
Plant Sciences
Pieter Nibbering, Romain Castilleux, Gunnar Wingsle, Totte Niittyla
Summary: Cellulose deficiency in Arabidopsis thaliana mutants with impaired CAGE1 and CAGE2 enzymes may be caused by defects in arabinogalactan biosynthesis, resulting in primary and secondary cell wall defects.
Article
Plant Sciences
Huiying Wang, Jing Liu, Wei Zhao, William Terzaghi, Linbin Deng, Hongfang Liu, Qiwei Zheng, Shihang Fan, Wei Hua, Ming Zheng
Summary: This paper investigated a protein called DELAYED GREENING 409 (DG409) in Arabidopsis, which was found to be involved in RNA editing and development of both chloroplasts and mitochondria.
Article
Plant Sciences
Muhammad Sayyar Khan, Qiao Lu, Man Cui, Hala Rajab, Huilan Wu, Tuanyao Chai, Hong-Qing Ling
Summary: The deficiency of iron and sulfur is a global concern, and the mechanisms of their sensing and signaling are not well understood. This study investigated the crosstalk between iron and sulfur and found dynamic regulatory relationships between them.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Bing Yang, Chenyun Xu, Yuting Cheng, Ting Jia, Xueyun Hu
Summary: Iron-sulfur (Fe-S) clusters are ancient protein cofactors that exist ubiquitously in organisms and play important roles in various life processes. Plastids, semi-autonomous organelles believed to originate from cyanobacterial endosymbionts, have a Fe-S cluster biosynthesis and delivery pathway similar to cyanobacteria. Fe-S clusters are crucial for the normal functioning of downstream Fe-S proteins in plastids. Recent research has made significant progress in understanding this pathway and this review summarizes these findings as well as the remaining scientific challenges.
PLANT CELL REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Michael S. Petronek, Douglas R. Spitz, Bryan G. Allen
Summary: Cancer cells have a higher demand for iron due to their differential need for Fe-S biogenesis, which promotes cell growth and genomic stability. Researchers suggest that targeting Fe-S biogenesis through redox manipulation, Fe chelation, and Fe mimicry could be potential therapeutic strategies for cancer treatment.
Review
Chemistry, Inorganic & Nuclear
Simone Ciofi-Baffoni, Claudia Andreini
Summary: Iron-sulfur clusters are protein cofactors that are crucial for cellular functions. CIAPIN1 proteins, which bind to iron-sulfur clusters, are involved in electron transfer pathways and cell death regulation. This study investigates the occurrence of CIAPIN1 proteins in different organisms and discusses their function and the role of Fe/S clusters.
Article
Biochemistry & Molecular Biology
Beatrice Bargagna, Sara Matteucci, Simone Ciofi-Baffoni, Francesca Camponeschi, Lucia Banci
Summary: Assembly of [4Fe-4S](2+) clusters in human cytosol requires a [2Fe-2S] cluster chaperone and an electron donor, and the mechanism of cytosolic [4Fe-4S](2+) cluster assembly is still unknown.
Article
Multidisciplinary Sciences
Kenji M. Fujihara, Bonnie Z. Zhang, Thomas D. Jackson, Moses O. Ogunkola, Brunda Nijagal, Julia Milne, David A. Sallman, Ching-Seng Ang, Iva Nikolic, Conor J. Kearney, Simon J. Hogg, Carlos S. Cabalag, Vivien R. Sutton, Sally Watt, Asuka T. Fujihara, Joseph A. Trapani, Kaylene J. Simpson, Diana Stojanovski, Silke Leimkuhler, Sue Haupt, Wayne A. Phillips, Nicholas J. Clemons
Summary: Eprenetapopt acts as an anticancer agent by increasing cellular antioxidant glutathione turnover, leading to ferroptosis, a nonapoptotic form of cell death. It also inhibits iron-sulfur cluster biogenesis and synergizes with dietary serine and glycine restriction to inhibit tumor growth.
Article
Plant Sciences
Chuanling Li, Jian-Xiu Shang, Chenlei Qiu, Baowen Zhang, Jinxue Wang, Shuo Wang, Yu Sun
Summary: The study suggests that the EMB2726 protein plays a critical role in Arabidopsis embryogenesis by affecting chloroplast development, possibly through impacting the transcription process within plastids. The presence of undifferentiated proplastids in emb2726 embryos, along with reduced expression of certain genes, highlights the significance of this gene in embryonic development.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Liliana S. O. Silva, Pedro M. Matias, Celia Romao, Ligia M. Saraiva
Summary: Repair of Iron Center proteins (RIC) are a family of di-iron proteins found widely in microbes. This review summarizes the data on microbial RICs, including their gene regulation and contribution to pathogenic bacteria survival. The focus is on Escherichia coli RIC, with extensive biochemical characterization and new structural data featuring a di-manganese site. The networking of protein interactions involving RIC and its proposed physiological role as an iron donor for repairing damaged iron-sulfur centers are also described.
Article
Biochemistry & Molecular Biology
Francesca Camponeschi, Lucia Banci
Summary: Metals play essential roles in biological systems and their transportation inside cells requires complex and selective pathways involving multiprotein machineries. Integrated approaches are necessary to study metal trafficking in cells at atomic resolution.
Article
Biochemistry & Molecular Biology
Dafne Suraci, Giovanni Saudino, Veronica Nasta, Simone Ciofi-Baffoni, Lucia Banci
Summary: The study reveals the coordinated mechanism of ISCA1, ISCA2, and NFU1 in the maturation process of mitochondrial [4Fe-4S] proteins. ISCA1 plays a key role in promoting the interaction between NFU1 and ISCA2, leading to the formation of a transient ISCA1-ISCA2-NFU1 ternary complex. This mechanism ensures the safe transfer of [4Fe-4S] clusters from the assembly site on the ISCA1-ISCA2 complex to NFU1, making them available for mitochondrial apo proteins that require NFU1.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Felipe A. Carvalho, Ulrich Muehlenhoff, Joseph J. Braymer, Vasilij Root, Martin Stuempfig, Carla C. Oliveira, Roland Lill
Summary: Systematic studies have shown that the Hsp90 chaperone system and Fe/S protein biogenesis or iron regulation are interconnected. DJA5 and DJA6 are two chloroplast-localized proteins that act as iron donors in plastidial Fe/S protein biogenesis. In this study, the impact of Hsp90 chaperone, yeast DJA5-DJA6 homologs, cytosolic Ydj1, and mitochondrial Mdj1 on cellular iron-related processes was investigated using Saccharomyces cerevisiae. Depletion of these crucial proteins resulted in severe phenotypes, but did not have a critical in vivo impact on Fe/S protein biogenesis or iron regulation. Unlike plant DJA5-DJA6 iron chaperones, Ydj1 and Mdj1 did not bind iron in vivo, suggesting that zinc is used for their function under normal physiological conditions.
Article
Biochemistry & Molecular Biology
Kouhei Kunichika, Ryosuke Nakamura, Takashi Fujishiro, Yasuhiro Takahashi
Summary: The study determined the crystal structure of IscU from Methanothrix thermoacetophila, revealing a dimer structure with two [2Fe-2S] clusters in a specific arrangement. It was confirmed that two adjacent [2Fe-2S] clusters can be converted to a [4Fe-4S] cluster via reductive coupling in solution, with His106 identified to play a functional role in this process.
Review
Chemistry, Inorganic & Nuclear
Jason C. Crack, Nick E. Le Brun
Summary: Iron-sulfur (FeS) clusters are protein cofactors essential for various biological functions such as electron transfer, catalysis, and gene regulation. Recent progress in using mass spectrometry has provided new insights into FeS cluster assembly and chemistry, particularly in transcriptional regulators coordinating cellular responses to changing conditions.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Indranil Basak, Ketan S. Patil, Guido Alves, Jan Petter Larsen, Simon Geir Moller
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Article
Geriatrics & Gerontology
Rashed Abdullah, Indranil Basak, Ketan S. Patil, Guido Alves, Jan Petter Larsen, Simon Geir Moller
EXPERIMENTAL GERONTOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Mohammad-Saeid Jami, Zahra Salehi-Najafabadi, Fereshteh Ahmadinejad, Esthelle Hoedt, Morteza Hashemzadeh Chaleshtori, Mandi Ghatrehsamani, Thomas A. Neubert, Jan Fetter Larsen, Simon Geir Moller
NEUROCHEMISTRY INTERNATIONAL
(2015)
Article
Multidisciplinary Sciences
Eric Linster, Iwona Stephan, Willy V. Bienvenut, Jodi Maple-Grodem, Line M. Myklebust, Monika Huber, Michael Reichelt, Carsten Sticht, Simon Geir Moller, Thierry Meinnel, Thomas Arnesen, Carmela Giglione, Ruediger Hell, Markus Wirtz
NATURE COMMUNICATIONS
(2015)
Article
Clinical Neurology
Johannes Lange, Kristin Aaser Lunde, Camilla Sletten, Simon Geir Moller, Ole-Bjorn Tysnes, Guido Alves, Jan Petter Larsen, Jodi Maple-Grodem
PARKINSONS DISEASE
(2015)
Article
Neurosciences
Shubhangi Prabhudesai, Fatima Zahra Bensabeur, Rashed Abdullah, Indranil Basak, Solange Baez, Guido Alves, Nathalia G. Holtzman, Jan Petter Larsen, Simon Geir Moller
JOURNAL OF NEUROSCIENCE RESEARCH
(2016)
Article
Neurosciences
Rashed Abdullah, Ketan S. Patil, Benjamin Rosen, Ramavati Pal, Shubhangi Prabhudesai, Sungsu Lee, Indranil Basak, Esthelle Hoedt, Peter Yang, Keith Panick, Hsin-Pin Ho, Emmanuel Chang, Charalampos Tzoulis, Jan Petter Larsen, Thomas A. Neubert, Guido Alves, Simon G. Moller
MOLECULAR NEUROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Mahmud Arif Pavel, Caixia Lv, Courtney Ng, Lei Yang, Parul Kashyap, Clarissa Lam, Victoria Valentino, Helen Y. Fung, Thomas Campbell, Simon Geir Moller, David Zenisek, Nathalia G. Holtzman, Yong Yu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Gyorgy Szabadkai, Mark Odell, M. Rhyan Puno, Benny Bjorkblom, Jodi Maple-Grodem, Peter Breuer, Oliver Kaut, Jan Petter Larsen, Stefan Bonn, Simon Geir Moller, Ullrich Wuellner, Anthony H. V. Schapira, Matthew E. Gegg
HUMAN MOLECULAR GENETICS
(2017)
Article
Neurosciences
Ramavati Pal, Guido Alves, Jan Petter Larsen, Simon Geir Moller
MOLECULAR NEUROBIOLOGY
(2014)
Review
Neurosciences
Alberim Kurtishi, Benjamin Rosen, Ketan S. Patil, Guido W. Alves, Simon G. Moller
MOLECULAR NEUROBIOLOGY
(2019)
Article
Plant Sciences
Aisling Dunne, Jodi Maple-Grodem, Daniela Gargano, Richard P. Haslam, Johnathan A. Napier, Nam-Hai Chua, Rosalind Russell, Simon Geir Moller
Article
Multidisciplinary Sciences
Ketan S. Patil, Indranil Basak, Ramavati Pal, Hsin-Pin Ho, Guido Alves, Emmanuel J. Chang, Jan Petter Larsen, Simon Geir Moller
Article
Neurosciences
Benjamin Rosen, Alberim Kurtishi, Gonzalo R. Vazquez-Jimenez, Simon Geir Moller
Summary: SARS-CoV-2 infection can lead to neurological symptoms similar to Parkinson's disease, and both conditions share common biochemical pathways. Despite the unclear relationship between the two, research has identified similarities that provide guidance for future studies.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fereshteh Ahmadinejad, Simon Geir Moller, Morteza Hashemzadeh-Chaleshtori, Gholamreza Bidkhori, Mohammad-Saeid Jami