Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice

(2015) Ao Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filamin-A Increases the Stability and Plasma Membrane Expression of Polycystin-2

(2015) Qian Wang et al.   PLoS One

The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function

(2014) Ivana Y. Kuo et al.   FASEB JOURNAL

Altered trafficking and stability of polycystins underlie polycystic kidney disease

(2014) Yiqiang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct recording and molecular identification of the calcium channel of primary cilia

(2013) Paul G. DeCaen et al.   NATURE

Primary cilia are specialized calcium signalling organelles

(2013) Markus Delling et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Calcium-induced Conformational Changes in C-terminal Tail of Polycystin-2 Are Necessary for Channel Gating

(2012) Andjelka S. Ćelić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Interaction and Functional Regulation of Polycystin-2 by Filamin

(2012) Qian Wang et al.   PLoS One

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex

(2012) Yong Yu et al.   Nature Communications

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

(2011) S. Field et al.   DEVELOPMENT

Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis

(2011) K. Kamura et al.   DEVELOPMENT

Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach

(2011) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex

(2010) Chisato Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation

(2010) S. Mangos et al.   Disease Models & Mechanisms

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes

(2010) Aurélie Giamarchi et al.   EMBO JOURNAL

Forward Genetic Analysis Reveals Multiple Gating Mechanisms of TRPV4

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity

(2010) E. T. Petri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystins and Primary Cilia: Primers for Cell Cycle Progression

(2009) Jing Zhou   Annual Review of Physiology

Ca2+-dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2

(2009) Frank Schumann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis

(2009) Xian-ping Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

(2009) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

(2009) E. B. E. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton

(2008) Xing-Zhen Chen et al.   FEBS Journal

Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2

(2008) Shuang Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPP2 and TRPV4 form a polymodal sensory channel complex

(2008) Michael Köttgen et al.   JOURNAL OF CELL BIOLOGY

Multiple Unbiased Prospective Screens Identify TRP Channels and Their Conserved Gating Elements: Figure 1.

(2008) Benjamin R. Myers et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia

(2008) Matthew J Rock et al.   NATURE GENETICS

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

(2008) Benjamin R. Myers et al.   NEURON

Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume

(2008) Takahiro Shimizu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY