International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

The dawning of a new age of toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology

(2016) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

Putative adverse outcome pathways relevant to neurotoxicity

(2015) Anna Bal-Price et al.   CRITICAL REVIEWS IN TOXICOLOGY

Epigenetics and Transcriptomics to Detect Adverse Drug Effects in Model Systems of Human Development

(2014) Nina V. Balmer et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Integrated assessment of runoff from livestock farming operations: Analytical chemistry, in vitro bioassays, and in vivo fish exposures

(2014) Jenna E. Cavallin et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Biological and medical applications of a brain-on-a-chip

(2014) David Pamies et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

(2014) M. E. Bette Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Neurobehavioural effects of developmental toxicity

(2014) Philippe Grandjean et al.   LANCET NEUROLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

(2014) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Developmental and maintenance defects in Rett syndrome neurons identified by a new mouse staging system in vitro

(2014) Gabriele Baj et al.   Frontiers in Cellular Neuroscience

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals

(2014) Kevin Crofton   ALTEX-Alternatives to Animal Experimentation

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

(2014) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Towards tailored assays for cell-based approaches to toxicity testing

(2014) Gian Paolo Rossini   ALTEX-Alternatives to Animal Experimentation

Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Systems toxicology

(2014) Thomas HArtung   ALTEX-Alternatives to Animal Experimentation

Metabolomics in toxicology and preclinical research

(2014) Tzutzuy Ramirez   ALTEX-Alternatives to Animal Experimentation

Uncertainty of testing methods – What do we (want to) know?

(2014) Martin Paparella   ALTEX-Alternatives to Animal Experimentation

Food for Thought … Mechanistic Validation

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

(2014) Richard Judson   ALTEX-Alternatives to Animal Experimentation

Integrated testing strategies for safety assessments

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Read-across approaches - misconceptions, promises and challenges ahead

(2014) Grace Patlewicz   ALTEX-Alternatives to Animal Experimentation

Consensus report on the future of animal-free systemic toxicity testing

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

Pathways of Toxicity

(2014) Andre Kleensang et al.   ALTEX-Alternatives to Animal Experimentation

Test systems of developmental toxicity: state-of-the art and future perspectives

(2013) Marcel Leist et al.   ARCHIVES OF TOXICOLOGY

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants

(2013) Anne K. Krug et al.   ARCHIVES OF TOXICOLOGY

Use of cortical neuronal networks for in vitro material biocompatibility testing

(2013) Hamid Charkhkar et al.   BIOSENSORS & BIOELECTRONICS

miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing

(2013) Giorgia Pallocca et al.   CELL BIOLOGY AND TOXICOLOGY

The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality

(2013) Matias S. Attene-Ramos et al.   DRUG DISCOVERY TODAY

Integrated testing and assessment approaches for skin sensitization: a commentary

(2013) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

Pesticide Exposure and Neurodevelopmental Outcomes: Review of the Epidemiologic and Animal Studies

(2013) Carol J. Burns et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Assessment of the developmental neurotoxicity of compounds by measuring locomotor activity in zebrafish embryos and larvae

(2013) Ingrid W.T. Selderslaghs et al.   NEUROTOXICOLOGY AND TERATOLOGY

Establishing the level of safety concern for chemicals in food without the need for toxicity testing

(2013) Benoît Schilter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Multidimensional In Vivo Hazard Assessment Using Zebrafish

(2013) Lisa Truong et al.   TOXICOLOGICAL SCIENCES

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

(2013) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

The DNT-EST: A predictive embryonic stem cell-based assay for developmental neurotoxicity testing in vitro

(2013) Katrin Hayess et al.   TOXICOLOGY

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

A Computational Model Predicting Disruption of Blood Vessel Development

(2013) Nicole Kleinstreuer et al.   PLoS Computational Biology

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

(2012) Lisa Hoelting et al.   ARCHIVES OF TOXICOLOGY

The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models

(2012) Heike Heuer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Developmental neurotoxicity guideline study: Issues with methodology, evaluation and regulation*

(2012) Ryozo Tsuji et al.   CONGENITAL ANOMALIES

Developmental neurotoxicity testing: A path forward

(2012) Kevin M. Crofton et al.   CONGENITAL ANOMALIES

Neuronal polarity: demarcation, growth and commitment

(2012) Alfredo Cáceres et al.   CURRENT OPINION IN CELL BIOLOGY

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells

(2012) Bastian Zimmer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth

(2012) Gary A. Wayman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Compound selection for in vitro modeling of developmental neurotoxicity

(2012) Suzanne Kadereit   Frontiers in Bioscience-Landmark

Zebrafish as potential model for developmental neurotoxicity testing

(2012) Celine de Esch et al.   NEUROTOXICOLOGY AND TERATOLOGY

Brain anomalies in children exposed prenatally to a common organophosphate pesticide

(2012) V. A. Rauh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos

(2012) John Cowden et al.   REPRODUCTIVE TOXICOLOGY

Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn)

(2012) P.T. Theunissen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics

(2012) Fikret E. Kapucu et al.   Frontiers in Computational Neuroscience

Validation and quality control of replacement alternatives – current status and future challenges

(2012) Marcel Leist et al.   Toxicology Research

Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1

(2011) Matthew T Martin et al.   BIOLOGY OF REPRODUCTION

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide

(2011) Virginia Rauh et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

(2011) Christoph van Thriel et al.   NEUROTOXICOLOGY

Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables

(2011) S. Padilla et al.   NEUROTOXICOLOGY AND TERATOLOGY

Impact of Prenatal Exposure to Piperonyl Butoxide and Permethrin on 36-Month Neurodevelopment

(2011) M. K. Horton et al.   PEDIATRICS

Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)

(2011) Peter T. Theunissen et al.   TOXICOLOGICAL SCIENCES

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Comparative sensitivity of human and rat neural cultures to chemical-induced inhibition of neurite outgrowth

(2011) Joshua A. Harrill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Species-Specific Differential AhR Expression Protects Human Neural Progenitor Cells against Developmental Neurotoxicity of PAHs

(2010) Kathrin Gassmann et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study

(2010) Karen H. Watanabe et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The Caenorhabiditis elegans model as a reliable tool in neurotoxicology

(2010) Daiana Avila et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Oral gavage subchronic neurotoxicity and inhalation subchronic immunotoxicity studies of ethylbenzene in the rat

(2010) Abby A. Li et al.   NEUROTOXICOLOGY

Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2™ cells using automated high-content image analysis

(2010) Joshua A. Harrill et al.   NEUROTOXICOLOGY

Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: Evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons

(2010) Helena T. Hogberg et al.   NEUROTOXICOLOGY

Phenotypic checkpoints regulate neuronal development

(2010) Yehezkel Ben-Ari et al.   TRENDS IN NEUROSCIENCES

Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

(2009) Michaela Moors et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments

(2009) Shengde Wu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A Human Stem Cell-Based Model for Identifying Adverse Effects of Organic and Inorganic Chemicals on the Developing Nervous System

(2009) Leonora Buzanska et al.   STEM CELLS

A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426

(2008) Susan L. Makris et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Toxicity Data Landscape for Environmental Chemicals

(2008) Richard Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

(2008) J. A. Lieberman et al.   PHARMACOLOGICAL REVIEWS

Parallelogram Approach Using Rat-Human In Vitro and Rat In Vivo Toxicogenomics Predicts Acetaminophen-induced Hepatotoxicity in Humans

(2008) Anne S. Kienhuis et al.   TOXICOLOGICAL SCIENCES

Induction of drug metabolism: Species differences and toxicological relevance

(2008) Mark J. Graham et al.   TOXICOLOGY