Article
Medicine, General & Internal
Chao Yin, Zhishuai Ye, Jian Wu, Chenxing Huang, Le Pan, Huaiyu Ding, Lei Zhong, Lei Guo, Yan Zou, Xiang Wang, Ying Wang, Pan Gao, Xuejuan Jin, Xiaoxiang Yan, Yunzeng Zou, Rongchong Huang, Hui Gong
Summary: The study found that elevated levels of Wnt2 and Wnt4 in the serum of AMI patients were associated with adverse outcomes. Wnt2 and Wnt4 promote cardiac fibrosis by activating the beta-catenin/NF-kappa B signaling pathway, potentially impacting the cardiac function of AMI patients.
Article
Medicine, Research & Experimental
Kehinde S. Olaniyi, Stephanie E. Areloegbe
Summary: This study investigated the effects of acetate on cardiometabolic abnormalities associated with polycystic ovarian syndrome (PCOS) in a rat model. The results suggest that acetate protects against cardiac inflammation by suppressing PCSK9 and NF-kB-dependent mechanisms.
Article
Pharmacology & Pharmacy
Hai-Jun Li, Dan-Qing Li, Yu-Liang Zhang, Xiao-Fei Ding, Hai-Tao Gao, Ya Zhu, Jun Liu, Li-Xia Zhang, Jie Chen, Guang Chen, Ying Yu
Summary: The modulation of the gut microbiota has been proposed as a potential therapeutic strategy for cerebral ischemia/reperfusion injury (CIRI). This study investigated the changes in the gut microbiota after CIRI and the effects of fecal microbiota transplant (FMT) on the brain. The findings suggest that FMT can attenuate CIRI in rats by inhibiting microglial M1 polarization through the ERK and NF-kappa B pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Abd El-Nasser A. Madboli, Mohamed M. Seif
Summary: This experimental study aimed to clarify the protective role of Adiantum capillus-veneris linn plant extracts (ACVL) in female rat reproductive organs intoxicated by carbendazim pesticide (CBZ). The results showed that CBZ toxicity induced histopathological changes and the ACVL plant extract acted as a protective factor by decreasing the synthesis of NF-kappa B-P65.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Medicinal
Ruihui Pei, Chaolong Duan, Annamalai Vijayalakshmi
Summary: The study demonstrated that Hecogenin (HCG) has a cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in rats, and this effect is achieved by inhibiting the activation of the NF-kappa B and p53 signaling pathway.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Medicine, Research & Experimental
Aliah R. Alshanwani, Azza M. Mohamed, Laila M. Faddah, Sameerah Shaheen, Maha M. Arafah, Hanan Hagar, Ahlam M. Alhusaini, Fatima M. B. Alharbi, Alaa AlHarthii, Amira M. Badr
Summary: The study showed that COB and/or CAL played an important protective role in TAMO-induced renal injury by inhibiting NF-kappa beta-mediated inflammation and caspase-3-induced apoptosis. The combination treatment of these two vitamins had a more significant therapeutic effect.
Article
Medicine, General & Internal
Xiaosheng Fan, Yan Yang, Lin Qi
Summary: The protective role of Vildagliptin in hypoxia-reoxygenation (H/R)-induced injury of cardiac microvascular endothelial cells (CMECs) and its pharmacological mechanisms were investigated in this study. H/R resulted in upregulation of DPP-4 and Nox-4, increased LDH release, and decreased viability and GSH content in CMECs. Vildagliptin treatment relieved these changes and inhibited the activation of the p38/NF-kappa B signaling in H/R-induced CMECs. Overall, Vildagliptin protects CMECs from H/R injury through inactivating the p38/NF-kappa B signaling pathway.
Article
Integrative & Complementary Medicine
Jing Li, Xuming Ma, Jun Yang, Luzhen Wang, Yan Huang, Yan Zhu
Summary: This study demonstrates for the first time that lupeol has a cardioprotective effect against I/R-induced myocardial infarction in rats, possibly due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The results also reveal the mechanisms of the NF-kappa B and Nrf2 signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sisi Huang, Kaiyue Wang, Dongyan Huang, Xin Su, Rongfu Yang, Congcong Shao, Juan Jiang, Jianhui Wu
Summary: This study found that lower doses of BPAF can promote dorsal prostatic hyperplasia in rats by interfering with multiple biomarkers in the NF-kappa B signaling pathway. These findings further confirm the toxic effect of BPAF on prostate health and provide important clues to the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xin Shi, Shaopin Zhu, Huiyi Jin, Junwei Fang, Xindan Xing, Yihan Wang, Hanying Wang, Chingyi Wang, Tian Niu, Kun Liu
Summary: The study revealed that KS23 had therapeutic effects on endotoxin-induced uveitis in rats, reduced infiltration of inflammatory cells, and levels of inflammatory cytokines. It also showed inhibitory effects on LPS-stimulated RAW 264.7 cells, suggesting KS23 as a promising therapeutic candidate for ocular inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chenghu Guo, Wei Ji, Wei Yang, Qiming Deng, Tengfei Zheng, Zunzhe Wang, Wenhai Sui, Chungang Zhai, Fangpu Yu, Bo Xi, Xiao Yu, Feng Xu, Qunye Zhang, Wencheng Zhang, Jing Kong, Meng Zhang, Cheng Zhang
Summary: Myocardial infarction is a leading cause of death worldwide. Cardiac fibroblasts are responsible for cardiac repair post-MI. NF-κB-repressing factor plays a significant role in cardiac remodeling post-MI.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ratul Datta Chaudhuri, Anirban Banik, Biswajit Mandal, Sagartirtha Sarkar
Summary: HIF-1α overexpression during MI reduces cardiomyocyte apoptosis by indirectly promoting HO-1-induced antioxidant response, which leads to decreased ROS accumulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Laura Tesoro, Ignacio Hernandez, Rafael Ramirez-Carracedo, Javier Diez-Mata, Nunzio Alcharani, Beatriz Jimenez-Guirado, Karina Ovejero-Paredes, Marco Filice, Jose Luis Zamorano, Marta Saura, Carlos Zaragoza, Laura Botana
Summary: This study introduced a micelle-based nanoparticle called NIL10, which targets the IL-10 receptor and was found to induce cardiac protection in mice and pigs with acute myocardial infarction (AMI). The administration of NIL10 reduced inflammation and fibrosis, increased the population of M2-like macrophages, and elevated anti-inflammatory cytokines. Mechanistically, NIL10 activated the IL-10 receptor/STAT-3 signaling pathway and inhibited the nuclear translocation of pro-inflammatory NF-kappa B transcription factor. These findings suggest that NIL10 could be a potential therapeutic tool against AMI-induced cardiac damage.
Article
Biochemistry & Molecular Biology
Mehtap Savran, Halil Asci, Yalcin Erzurumlu, Ozlem Ozmen, Ilter Ilhan, M. Cem Sirin, Nasif Fatih Karakuyu, Adnan Karaibrahimoglu
Summary: This study aims to evaluate the potential protective effects of Theranekron (TH) on acetic acid (AA)-induced colonic damage and describe the possible mechanisms of TH.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Geriatrics & Gerontology
Fang Dou, YueTong Liu, Limin Liu, Jingwen Wang, Ting Sun, Fei Mu, Qiyan Guo, Chao Guo, Na Jia, Wenxin Liu, Yi Ding, Aidong Wen
REJUVENATION RESEARCH
(2019)
Article
Cell Biology
Yan Weng, Jingwen Wang, Zhifu Yang, Miaomiao Xi, Jialin Duan, Chao Guo, Ying Yin, Ryosuke Segawa, Takahiro Moriya, Takayuki Yonezawa, Byung Yoon Cha, Je-Tae Woo, Aidong Wen, Noriyasu Hirasawa
CELLULAR SIGNALLING
(2019)
Article
Immunology
Jialin Duan, Jia Cui, Zhifu Yang, Chao Guo, Jinyi Cao, Miaomiao Xi, Yan Weng, Ying Yin, Yanhua Wang, Guo Wei, Boling Qiao, Aidong Wen
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Cell Biology
Jialin Duan, Jia Cui, Hongnan Zheng, Miaomiao Xi, Chao Guo, Yan Weng, Ying Yin, Guo Wei, Jinyi Cao, Yanhua Wang, Aidong Wen, Boling Qiao
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang
Article
Cell Biology
Jia Cui, Jialin Duan, Jianjie Chu, Chao Guo, Miaomiao Xi, Yi Li, Yan Weng, Guo Wei, Ying Yin, Aidong Wen, Boling Qiao
Article
Immunology
Tianlong Liu, Wenjun Wang, Minna Liu, Yang Ma, Fei Mu, Xiaona Feng, Yikai Zhang, Chao Guo, Yi Ding, Aidong Wen
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Chemistry, Physical
Yi Ding, Minchun Chen, Chao Guo, Peng Zhang, Jingwen Wang
Summary: This study developed quantitative structure-activity relationship (QSAR) models for predicting the properties of ionic liquids (ILs) by using molecular fingerprint (MF) and machine learning (ML). The models showed comparative predictive performance with traditional methods and can quickly obtain representations of IL within milliseconds. The trustworthiness of the models was enhanced by interpreting them using the shapely additive explanation (SHAP) method.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Neurosciences
Shanbo Ma, Rui Zhang, Long Li, Hui Qu, Jin Wang, Qian Yang, Chao Guo, Shan Miao, Xiaopeng Shi
Summary: Xanthohumol has been shown to inhibit the phosphorylation of protein kinase B and nuclear factor kappa-B in diabetic rats, leading to decreased blood glucose levels, increased body weight, and improved fear memory retention. Additionally, XN treatment resulted in enhanced synaptic plasticity and dendritic spine density, as well as decreased reactive oxygen species levels in the hippocampus slices of diabetic rats, suggesting its potential as a promising treatment for diabetic encephalopathy.
Article
Pharmacology & Pharmacy
Juanli Zhang, Jiaxin Zhao, Yang Ma, Wenjun Wang, Shaojie Huang, Chao Guo, Kai Wang, Xiaomei Zhang, Wei Zhang, Aidong Wen, Ming Shi, Yi Ding
Summary: This study utilized a combination of systems pharmacology and experimental assessment to investigate the bioactive components, core targets, and possible mechanisms of Guanxin-Shutong capsule (GXSTC) in treating cerebrovascular diseases (CBVDs). The results revealed that GXSTC exerts a multi-target synergetic mechanism in CBVDs by maintaining vascular endothelial function, inhibiting neuronal apoptosis, and inflammatory processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Yu-cheng Liao, Jing-wen Wang, Juan-li Zhang, Chao Guo, Xin-liang Xu, Kai Wang, Chao Zhao, Ai-dong Wen, Rui-li Li, Yi Ding
Summary: QFZTC contains seven active ingredients identified through HPLC, with network pharmacology analysis revealing TLR4, TNF, IL6, IL1 beta, and c-Fos as core targets. Through regulating the TLR4/MyD88/NF-kappa B signaling pathway in spinal microglia, QFZTC significantly alleviated neuropathic pain in mice models.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yucheng Liao, Jingwen Wang, Chao Guo, Min Bai, Bowei Ju, Zheng Ran, Junping Hu, Jianhua Yang, Aidong Wen, Yi Ding
Summary: This study explored the active components, core targets, and synergistic mechanisms of Frankincense-Myrrh in the treatment of cerebrovascular diseases (CBVDs) using systems pharmacology and experimental research. The results showed that Frankincense-Myrrh mainly regulated neurotrophic factors and inflammatory responses, leading to significant improvements in neurological function and reduction in infarct volume.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Chao Guo, Wen-Jun Wang, Yu-Cheng Liao, Chao Zhao, Ying Yin, Min-Na Yao, Yi Ding, Jing-Wen Wang
Summary: Quercetin, extracted from tea, onions, and apples, has a neuroprotective effect on experimental ischemic stroke. This systematic review and meta-analysis found that quercetin significantly improved neurological function score and reduced infarct volume. It also alleviated blood-brain barrier permeability and brain water content. The mechanisms of quercetin against focal cerebral ischemia involve antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. Although the effect size may be overestimated due to study quality and publication bias, quercetin shows potential as a neuroprotective agent for human ischemic stroke.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Wei Quan, Hui-xian Liu, Wei Zhang, Wei-juan Lou, Yang-ze Gong, Chong Yuan, Qing Shao, Na Wang, Chao Guo, Fei Liu
Summary: The study demonstrates that Rosmarinic acid (RosA) can significantly reduce myocardial infarct size, cardiac dysfunction, release of myocardial injury enzymes, cell death, and oxidative stress caused by myocardial ischemia/reperfusion injury.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Cell Biology
Jingwen Wang, Shiquan Wang, Sisi Sun, Yunyang Lu, Kai Gao, Chao Guo, Ruili Li, Weiwei Li, Xian Zhao, Haifeng Tang, Aidong Wen, Min Cai, Wei Zhang
