Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons

Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation

(2014) Massimo Stefani et al.   BIOFACTORS

Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism

(2014) V. Annese et al.   Brain Structure & Function

In vitro aggregation assays for the characterization of α-synuclein prion-like properties

(2014) Joanna Narkiewicz et al.   Prion

Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells

(2014) Y-C Hsu et al.   Cell Death & Disease

The emerging role of nutrition in Parkinson's disease

(2014) Stacey E. Seidl et al.   Frontiers in Aging Neuroscience

LAMP2A as a therapeutic target in Parkinson disease

(2013) Maria Xilouri et al.   Autophagy

The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease

(2013) Li Zuo et al.   GENE

Cucurbitacin E exhibits anti-inflammatory effect in RAW 264.7 cells via suppression of NF-κB nuclear translocation

(2013) Jing Qiao et al.   INFLAMMATION RESEARCH

AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells

(2013) CHINGJU LIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Resveratrol Protects DAergic PC12 Cells from High Glucose-Induced Oxidative Stress and Apoptosis: Effect on p53 and GRP75 Localization

(2013) Justine Renaud et al.   NEUROTOXICITY RESEARCH

Peroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 Mediates Neuronal Autophagy after Cerebral Ischemia-Reperfusion Injury

(2013) Feng Xu et al.   PLoS One

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

(2013) Hélène Bugaut et al.   PLoS One

Nutraceutical Intervention Improves Older Adults' Cognitive Functioning

(2013) Brent J. Small et al.   REJUVENATION RESEARCH

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

The Natural Product Cucurbitacin E Inhibits Depolymerization of Actin Filaments

(2012) Pia M. Sörensen et al.   ACS Chemical Biology

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion

(2012) Tao Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins

(2012) Federico Pietrocola et al.   CELL CYCLE

Role of Resveratrol and its Analogues in the Treatment of Neurodegenerative Diseases: Focus on Recent Discoveries

(2012) V. Foti Cuzzola et al.   CNS & Neurological Disorders-Drug Targets

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease

(2012) Helineide Cristina Campos et al.   CNS & Neurological Disorders-Drug Targets

Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes ApoptosisviaFas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells

(2012) Wen-Wen Huang et al.   Evidence-based Complementary and Alternative Medicine

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Interactions between autophagic and endo-lysosomal markers in endothelial cells

(2012) Clara L. Oeste et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

(2012) Daniela M. Arduíno et al.   HUMAN MOLECULAR GENETICS

Classic and New Animal Models of Parkinson's Disease

(2012) Javier Blesa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System

(2012) Julie Bournival et al.   Oxidative Medicine and Cellular Longevity

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Inhibition of Autophagy Contributes to Ischemic Postconditioning-Induced Neuroprotection against Focal Cerebral Ischemia in Rats

(2012) Li Gao et al.   PLoS One

Quercetin and Sesamin Protect Neuronal PC12 Cells from High-Glucose-Induced Oxidation, Nitrosative Stress, and Apoptosis

(2012) Julie Bournival et al.   REJUVENATION RESEARCH

Dopamine Oxidation and Autophagy

(2012) Patricia Muñoz et al.   Parkinsons Disease

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition

(2011) Siddig Ibrahim Abdelwahab et al.   FITOTERAPIA

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

Inhibitors of Microglial Neurotoxicity: Focus on Natural Products

(2011) Dong Kug Choi et al.   MOLECULES

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Mitochondrial Metabolic Control of Microtubule Dynamics Impairs the Autophagic Pathway in Parkinson’s Disease

(2011) S.M. Cardoso et al.   Neurodegenerative Diseases

Oxidative Stress in Parkinson's Disease

(2010) Chun Zhou et al.   Annals of the New York Academy of Sciences

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

(2010) Abdelfatteh El Omri et al.   JOURNAL OF ETHNOPHARMACOLOGY

Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration

(2010) Daniele Cartelli et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets

(2010) Marcello Iriti et al.   MOLECULES

Nutraceutical Antioxidants as Novel Neuroprotective Agents

(2010) Natalie A. Kelsey et al.   MOLECULES

Time-course correlation of early toxic events in three models of striatal damage: Modulation by proteases inhibition

(2010) Verónica Pérez-De La Cruz et al.   NEUROCHEMISTRY INTERNATIONAL

Sesamin Modulates Tyrosine Hydroxylase, Superoxide Dismutase, Catalase, Inducible No Synthase and Interleukin-6 Expression in Dopaminergic Cells Under Mpp+-Induced Oxidative Stress

(2010) Vicky Lahaie-Collins et al.   Oxidative Medicine and Cellular Longevity

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

(2010) Rebecca Banerjee et al.   TRENDS IN NEUROSCIENCES

Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons

(2009) Julie Bournival et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Dining in with BCL-2: new guests at the autophagy table

(2009) Marc Germain et al.   CLINICAL SCIENCE

Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway

(2009) Nanako Hamada et al.   JOURNAL OF NEURAL TRANSMISSION

Role of autophagy and proteasome degradation pathways in apoptosis of PC12 cells overexpressing human α-synuclein

(2009) Fang Yang et al.   NEUROSCIENCE LETTERS

Differentiation induced byAchyrocline satureioides(Lam) infusion in PC12 cells

(2009) M. F. Blasina et al.   PHYTOTHERAPY RESEARCH

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

(2008) T. Pan et al.   BRAIN

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice

(2008) Julie Blanchet et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

(2007) Genevieve Bureau et al.   JOURNAL OF NEUROSCIENCE RESEARCH