MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis

Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart

(2015) Fang Wang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis

(2015) Yanqing Wu et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling

(2015) Peixin Yang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Advances in revealing the molecular targets downstream of oxidative stress–induced proapoptotic kinase signaling in diabetic embryopathy

(2015) Fang Wang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development

(2015) Fang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy

(2015) Fang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects

(2015) Jianxiang Zhong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus–Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt SignalingCLINICAL PERSPECTIVE

(2015) Fang Wang et al.   Circulation-Cardiovascular Genetics

Androgen Receptor Silences Thioredoxin-interacting Protein and Competitively Inhibits Glucocorticoid Receptor-Mediated Apoptosis in Pancreatic β-Cells

(2015) Naoki Harada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus–Induced Apoptosis and Heart Defects Through Restoration of Impaired Wnt SignalingCLINICAL PERSPECTIVE

(2015) Fang Wang et al.   Circulation-Cardiovascular Genetics

MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State

(2014) Yulin Li et al.   CANCER CELL

Ask1Gene Deletion Blocks Maternal Diabetes–Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome

(2014) Fang Wang et al.   DIABETES

The miR-322-TRAF3 Circuit Mediates the Pro-apoptotic Effect of High Glucose on Neural Stem Cells

(2014) Hui Gu et al.   TOXICOLOGICAL SCIENCES

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

(2013) E Mogilyansky et al.   CELL DEATH AND DIFFERENTIATION

miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration

(2013) Ran Zhuang et al.   NUCLEIC ACIDS RESEARCH

Maternal Hyperglycemia Activates an ASK1-FoxO3a-Caspase 8 Pathway That Leads to Embryonic Neural Tube Defects

(2013) P. Yang et al.   Science Signaling

MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes

(2012) Lucas Philippe et al.   ANNALS OF THE RHEUMATIC DISEASES

The MicroRNA-17-92 Family of MicroRNA Clusters in Development and Disease

(2012) Carla P. Concepcion et al.   CANCER JOURNAL

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Oxidative Stress-Induced JNK1/2 Activation Triggers Proapoptotic Signaling and Apoptosis That Leads to Diabetic Embryopathy

(2012) X. Li et al.   DIABETES

c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy

(2012) X. Li et al.   DIABETES

Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects

(2012) Hui Gu et al.   JOURNAL OF NEUROCHEMISTRY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

MicroRNA gene expression signatures in the developing neural tube

(2011) Partha Mukhopadhyay et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition

(2011) A Magenta et al.   CELL DEATH AND DIFFERENTIATION

Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines

(2011) Lan Xiao et al.   MOLECULAR BIOLOGY OF THE CELL

Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

(2011) Loïc de Pontual et al.   NATURE GENETICS

Neural tube defect genes and maternal diabetes during pregnancy

(2010) J. Michael Salbaum et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

High β-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice

(2009) Elodie Masson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Maternal diabetes alters transcriptional programs in the developing embryo

(2009) Gabriela Pavlinkova et al.   BMC GENOMICS

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Diabetes mellitus and birth defects

(2008) Adolfo Correa et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Lack of TXNIP protects β-cells against glucotoxicity: Figure 1

(2008) Anath Shalev   BIOCHEMICAL SOCIETY TRANSACTIONS

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

(2008) Andrea Ventura et al.   CELL

miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation

(2008) Kara M. Foshay et al.   DEVELOPMENTAL BIOLOGY

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES