Article
Biochemistry & Molecular Biology
Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu
Summary: The study showed that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis, but did not affect ROS-mediated tissue degeneration in SOD-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Article
Cardiac & Cardiovascular Systems
Lesia Savchenko, Ilenia Martinelli, Dimitri Marsal, Vyacheslav Zhdan, Junwu Tao, Oksana Kunduzova
Summary: This study investigated the effects of prolonged electromagnetic stress on the mitochondrial oxidative phosphorylation system and myocardial structure. It was found that electromagnetic stress alters mitochondrial respiratory capacity but does not result in cardiac abnormalities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Victoria E. Surratt, Stephen R. Koch, Ryan J. Stark, Fred S. Lamb
Summary: TNF alpha activates NADPH oxidase 1, which produces extracellular superoxide anion. The secreted protein ecSOD converts superoxide anion to hydrogen peroxide, playing a role in TNF alpha signaling in vascular smooth muscle cells. Knockdown of ecSOD suppresses downstream TNF alpha signals and reduces expression of TNF alpha receptors.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Li-Qiang Wang, Yeyang Ma, Han-Ye Yuan, Kun Zhao, Mu-Ya Zhang, Qiang Wang, Xi Huang, Wen-Chang Xu, Bin Dai, Jie Chen, Dan Li, Delin Zhang, Zhengzhi Wang, Liangyu Zou, Ping Yin, Cong Liu, Yi Liang
Summary: The authors determined the cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 during the pathogenesis of ALS.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Arduino Aleksander Mangoni, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro Giuseppe Fois, Pietro Pirina, Angelo Zinellu
Summary: The study found that whole blood SOD concentrations were significantly lower in patients with obstructive sleep apnoea, while serum/plasma SOD concentrations did not show a significant difference. This suggests an impaired antioxidant defence in OSA patients.
Article
Cell Biology
Shuya Gao, Qingchen Yang, Yue Peng, Weixian Kong, Zekun Liu, Zhe Li, Jiawen Chen, Mengmeng Bao, Xie Li, Yubin Zhang, Xiaohong Bian, Liang Jin, Hanwen Zhang, Yuexin Zhang, Daniel Sanchis, Fangrong Yan, Junmei Ye
Summary: This study highlights the beneficial role of SIRT6 in mitochondrial biogenesis and oxidative stress regulation in cardiomyocytes during obesity-induced cardiac injury, providing new insights into the pathogenesis of obesity-associated lipotoxicity in the heart.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Immunology
Yuan-Yi Zhang, Bai-Sui Feng, Huanping Zhang, Gui Yang, Qiao-Ruo Jin, Xiang-Qian Luo, Na Ma, Qin-Miao Huang, Li-Teng Yang, Guo-Hao Zhang, Da-Bo Liu, Yong Yu, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
Summary: Exposure to specific antigens induces apoptosis in Tregs, which can be prevented by regulating superoxide dismutase or suppressing reactive oxygen species.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Gordana Scepanovic, Miranda Victoria Hunter, Ran Kafri, Rodrigo Fernandez-Gonzalez
Summary: The research demonstrates that in Drosophila embryos, activation of p38 kinase helps limit wound size and promote rapid wound healing by increasing cell volume around the wound.
Article
Endocrinology & Metabolism
Bernardo de Moraes Meine, Thais Scolari Franceschi, Natalia Pontes Bona, Luiza Spohr, Nathalia Stark Pedra, Roselia Maria Spanevello, Mayara Sandrielly Soares de Aguiar, Francieli Moro Stefanello
Summary: This study investigated the effects of chronic administration of methionine and its metabolite methionine sulfoxide on oxidative damage in the brain, liver, and kidney of young mice. The results showed that these substances increased reactive oxygen species and lipoperoxidation levels, while reducing antioxidant enzyme activities. Furthermore, they also affected the liver and kidney functions. These findings contribute to a better understanding of the pathophysiological mechanisms of hypermethioninemia.
METABOLIC BRAIN DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Mengli Zheng, Yating Liu, Guanfeng Zhang, Zhikang Yang, Weiwei Xu, Qinghua Chen
Summary: Superoxide dismutase (SOD) is an enzyme that can respond to cellular oxidative stress and has shown effectiveness in anti-tumor, anti-radiation, and anti-aging studies. This research summarizes the types, biological functions, and applications of SODs, and highlights the challenges of membrane permeability and enzyme persistence.
Article
Chemistry, Multidisciplinary
Gwang-Bum Im, Young Geon Kim, Tae Yong Yoo, Yeong Hwan Kim, Kang Kim, Jiyu Hyun, Min Soh, Taeghwan Hyeon, Suk Ho Bhang
Summary: Copper-deposited ceria nanoparticles (CuCe NPs) exhibit enhanced antioxidant effects and therapeutic performance through the upregulation of specific biological factors, scavenging reactive oxygen species, and promoting anti-inflammation and M2 polarization of macrophages. In ischemic vascular diseases, CuCe NPs afford increased perfusion and alleviate tissue damage.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Pengfei Zhai, Yinyan Ma, Huan Xu, Ling Lu
Summary: This study demonstrates that MtmA is involved in responding to oxidative stress by activating mitochondrial SodB activity in A. fumigatus. MtmA, especially for the first Mito-carr domain, is essential for colony growth by regulating cellular Zn2+ equilibrium and responses to oxidative stress. This study reveals the vital and unique role of the MtmA protein in pathogenic fungi, suggesting its potential as a target for antifungal drugs.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrea Angeletti, Maurizio Bruschi, Xuliana Kajana, Sonia Spinelli, Enrico Verrina, Francesca Lugani, Gialuca Caridi, Corrado Murtas, Giovanni Candiano, Marco Prunotto, Gian Marco Ghiggeri
Summary: Glomerulonephritis is a renal disorder caused by various pathogenic mechanisms. Understanding the details of the pathogenic cascade is crucial in limiting disease progression. The balance between tissue injury, protective systems activation, and tissue repair determines the outcome. Oxidative stress plays a role in glomerular inflammation, and the activation of antioxidant systems is important in reducing tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuya Takahashi, Tatsunori Shimizu, Shunsuke Kato, Mitsuhiko Nara, Yumi Suganuma, Takehiro Sato, Tsukasa Morii, Yuichiro Yamada, Hiroki Fujita
Summary: The study found that KK/Ta-Ins2(Akita) mice exhibited delayed muscle regeneration after CTX injection, with significantly smaller average cross-sectional areas of regenerating TA muscle myofibers compared to KK/Ta-wild-type mice. Furthermore, there was markedly reduced SOD1 expression in CTX-injected TA muscles of KK/Ta-Ins2(Akita) mice, along with increased inflammatory cell infiltration, prominent fibrosis, and superoxide overproduction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
