Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

Chromatin in time and space

(2012) Gordon L. Hager et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts

(2011) Yann Grosse et al.   LANCET ONCOLOGY

Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice

(2011) Yingchang Lu et al.   PHYSIOLOGICAL GENOMICS

Trim24 (Tif1α): An essential ‘brake’ for retinoic acid-induced transcription to prevent liver cancer

(2010) Konstantin Khetchoumian et al.   CELL CYCLE

PPARα-Dependent Activation of Cell Cycle Control and DNA Repair Genes in Hepatic Nonparenchymal Cells

(2010) Aijuan Qu et al.   TOXICOLOGICAL SCIENCES

Effects of the PPARαAgonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism

(2010) Michael L. Cunningham et al.   PPAR Research

Gene Expression Profiling in Wild-Type and PPAR-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR-Independent Effects

(2010) Mitchell B. Rosen et al.   PPAR Research

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): A novel signalling pathway sensitive to phthalates

(2009) Alexandre Eveillard et al.   BIOCHEMICAL PHARMACOLOGY

Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens

(2009) Alan R. Boobis et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds

(2009) Elizabeth Julien* et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms

(2009) Jérôme N. Feige et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species

(2009) Hongzu Ren et al.   REPRODUCTIVE TOXICOLOGY

Characterization of Peroxisome Proliferator–Activated Receptor α—Independent Effects of PPARα Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate also Activates the Constitutive-Activated Receptor

(2009) Hongzu Ren et al.   TOXICOLOGICAL SCIENCES

Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach

(2009) Alexandre Eveillard et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genome-wide mechanisms of nuclear receptor action

(2009) Simon C. Biddie et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reactive species: A cell damaging rout assisting to chemical carcinogens

(2008) Mario E. Goetz et al.   CANCER LETTERS

Evaluation of the Role of Peroxisome Proliferator-Activated Receptor α (PPARα in Mouse Liver Tumor Induction by Trichloroethylene and Metabolites

(2008) J. Christopher Corton   CRITICAL REVIEWS IN TOXICOLOGY

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

(2008) M.E. Bette Meek   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Role of the p50 subunit of NF-κB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate

(2008) Karen G. Calfee-Mason et al.   FOOD AND CHEMICAL TOXICOLOGY

Androgen Receptor Is a New Potential Therapeutic Target for the Treatment of Hepatocellular Carcinoma

(2008) Weng–Lung Ma et al.   GASTROENTEROLOGY

Structural and Biochemical Basis for the Binding Selectivity of Peroxisome Proliferator-activated Receptor γ to PGC-1α

(2008) Yong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems

(2008) Miroslav Dostalek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH

Different Mechanisms of DEHP-induced Hepatocellular Adenoma Tumorigenesis in Wild-type and Pparα-null Mice

(2008) Kayoko Takashima et al.   JOURNAL OF OCCUPATIONAL HEALTH

A Natural Polymorphism in Peroxisome Proliferator-Activated Receptor-α Hinge Region Attenuates Transcription due to Defective Release of Nuclear Receptor Corepressor from Chromatin

(2008) Mei Hui Liu et al.   MOLECULAR ENDOCRINOLOGY

Effect of Synthetic Dietary Triglycerides: A Novel Research Paradigm for Nutrigenomics

(2008) Linda M. Sanderson et al.   PLoS One

Glucocorticoid receptor dynamics and gene regulation

(2008) Simon C. Biddie et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Comparative Hepatic Effects of Perfluorooctanoic Acid and WY 14,643 in PPAR-α Knockout and Wild-type Mice

(2008) Douglas C. Wolf et al.   TOXICOLOGIC PATHOLOGY

Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid

(2008) Mitchell B. Rosen et al.   TOXICOLOGIC PATHOLOGY

Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR

(2008) Mitchell B. Rosen et al.   TOXICOLOGICAL SCIENCES