Article
Chemistry, Organic
Fenghai Zhao, Thishana Singh, Yumei Xiao, Wangcang Su, Dongyan Yang, Changqing Jia, Jia-Qi Li, Zhaohai Qin
Summary: An efficient assembly of disubstituted 1,2,4-triazoles was achieved by cyclization of readily accessible N'-nitro-2-hydrocarbylidene-hydrazinecarboximidamides with moderate to excellent yields under mild reaction conditions. This divergent synthetic strategy allows for the formation of amino-1,2,4-triazoles under acidic conditions and nitroimino-1,2,4-triazoles under neutral conditions with water as the solvent.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Applied
Baofu Zhu, Wen Li, Haixin Chen, Minjian Wu, Jijing Hu, Hua Cao, Xiang Liu
Summary: A mechanochemical Cu-catalyzed [3 + 2] cycloaddition of azinium-N-imines with nitriles was reported under solventless grinding conditions. Various 1,2,4-triazolos derivatives were obtained in high yields. The developed protocol offers advantages in functional-group compatibility, scalability, and shorter reaction time.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Olcay Bekircan, Ozkan Danis, Mehmet Eren Sahin, Mert Cetin
Summary: This study reports the design, synthesis, and characterization of a series of 3,5-diphenyl-1,2,4-triazole substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as selective hMAO-B inhibitors. Compound 42e and 42h exhibited the highest inhibitory activity against hMAO-B.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jie Zheng, Shu-Yu Meng, Quan-Rui Wang, Jing-Mei Wang
Summary: Novel annulated azaheterocycles have been synthesized, showing antimicrobial activity against Staphylococcus aureus and potentially exerting antibiotic effects through DNA gyrase inhibition. The compounds were obtained through specific reactions and DFT calculations were used to further confirm the reaction mechanism.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Joseph Yount, Matthias Zeller, Edward F. C. Byrd, Davin G. Piercey
Summary: The novel energetic material DNDAABT was synthesized via mixed acid nitration of electrochemically generated TAABT, with various energetic salts also prepared and characterized. Despite predictions of low sensitivities, DNDAABT and its salts showed primary explosive sensitivities with relatively high thermal stabilities for primary N-nitramines.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
A. Satyanarayana Reddy, V. Krishna Reddy, G. Nageswara Rao, K. Basavaiah, Kalyan C. Nagulapalli C. Venkata
Summary: We developed a novel one-pot strategy to synthesize biologically important 1,2,4-triazole motifs from easily accessible starting materials. This strategy allows the synthesis of natural penipanoid A and its analogues in a single step.
Article
Chemistry, Organic
Matthew B. Williams, Alistair Boyer
Summary: A modular synthesis of highly substituted 3-azapyrroles has been developed using a three-step sequence comprising copper-catalyzed alkyne-azide cycloaddition, Rhodium(II)-acetate-promoted 1-ST denitrogenation, and cyclodehydration. The method proved to be highly efficient and tolerated a wide range of substituents.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Sierra C. Nguyen, Allen Y. Hong
Summary: A new two-step method for the preparation of annulated 1,2,4-triazoles has been developed, showing the incorporation of various annulated ring sizes into the resulting polycyclic triazoles.
TETRAHEDRON LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Abdallah Turky, Ashraf H. Bayoumi, Farag F. Sherbiny, Khaled El-Adl, Hamada S. Abulkhair
Summary: The study focused on the design, synthesis, pharmacokinetic profiles, and in vitro anticancer activity of novel C3-linked 1,2,4-triazole-N-arylamide hybrids for inhibition of STAT3. Four derivatives showed promising cytotoxic effects against selected cancer cells, with compound 12 exhibiting the highest potency. These compounds were analyzed for their potential as drug candidates based on their ADMET properties.
MOLECULAR DIVERSITY
(2021)
Article
Chemistry, Organic
Salimeh Abdinasab, Ali Darehkordi, Reza Ranjbar-Karimi, Alireza Abbasi
Summary: An I-2-mediated N-N coupling reaction was developed for the synthesis of novel 3-methyl-1-aryl-5-(trifluoromethyl)-1H-1,2,4-tri-azole derivatives in excellent yield without the need for purification. This method does not require the use of transition metal catalysts and can be performed on a gram scale.
SYNTHETIC COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Pavel S. Silaichev, Tetyana V. Beryozkina, Vladimir Ilkin, Mikhail S. Novikov, Wim Dehaen, Vasiliy A. Bakulev
Summary: An efficient metal-free method for synthesizing 5-amino-1,2,3-triazole-4-N-sulfonyl- and arylimidamides has been developed based on a tandem process involving cycloaddition reaction and Cornforth-type rearrangement. The reaction optimization identified several factors that facilitate the reaction, including the use of a strong base and specific 3,3-diaminoacrylonitriles. The method has a broad scope and can be applied to obtain various 5-amino-1,2,3-triazole-4-carbimidamides with different substituents.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Jian Ji, Cong Guan, Qinghua Wei, Xuwen Chen, Yun Zhao, Shunying Liu
Summary: This study developed a highly regioselective synthesis of N-2-substituted 1,2,3-triazoles using N-sulfonyl-1,2,3-triazoles and alkyl bromides/alkyl iodides at room temperature. The mechanistic pathway proposed explains the high N-2 regioselectivity, and the protocol showed good to excellent product yields (72-90%).
Article
Biochemistry & Molecular Biology
Han Luo, Yong-Feng Lv, Hong Zhang, Jiang-Miao Hu, Hong-Mei Li, Shou-Jin Liu
Summary: A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction, and most of them demonstrated cytotoxicity on five human cancer cell lines, with compounds 14 and 17 showing significant cytotoxicity across all five cancer cell lines.
Article
Chemistry, Organic
Dahan Wang, Xiaoyuan Wan, Yazheng Zhou, Jinbing Liu, Jinhui Cai, Guo-Jun Deng
Summary: An efficient method for the synthesis of densely 1,2,4-triazoles by [3+2] cycloaddition of nitrileimides with amidine hydrochlorides under transition metal-free conditions is reported. The method demonstrates mild reaction conditions, wide substrate scope, and good functional group tolerance. Various aryl, heterocyclic, and alkyl substituted 3-CF3-1,2,4-triazoles were synthesized with high yields up to 96% using NaHCO3 as a promoter. Additionally, the scalability and synthetic transformations of this method were successfully carried out, highlighting its utility.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Merve Zengin, Oya Unsal Tan, Reem Arafa, Ayla Balkan
Summary: This study designed and synthesized a series of novel compounds as potential antitumor agents and VEGFR-2 inhibitors. Eight compounds showed high growth inhibition against MCF-7 cells and possessed sub-micromolar range of VEGFR-2 inhibitory activity. Docking studies and in silico physicochemical predictions suggested promising drug-likeness profiles for these compounds.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ata Makarem, Regina Berg, Frank Rominger, Bernd F. Straub
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Article
Chemistry, Multidisciplinary
Matthias W. Hussong, Wilhelm T. Hoffmeister, Frank Rominger, Bernd F. Straub
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Article
Chemistry, Organic
Anne L. Schoeffler, Ata Makarem, Frank Rominger, Bernd F. Straub
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2016)
Editorial Material
Chemistry, Organic
Bernd F. Straub, Rolf Gleiter, Claudia Meier, Lutz H. Gade
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Nanoscience & Nanotechnology
Michael Wrede, Viktoria Ganza, Janina Bucher, Bernd F. Straub
ACS APPLIED MATERIALS & INTERFACES
(2012)
Article
Chemistry, Applied
Regina Berg, Johannes Straub, Ella Schreiner, Steffen Mader, Frank Rominger, Bernd F. Straub
ADVANCED SYNTHESIS & CATALYSIS
(2012)
Article
Chemistry, Multidisciplinary
Matthias W. Hussong, Frank Rominger, Petra Kraemer, Bernd F. Straub
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Review
Chemistry, Organic
Regina Berg, Bernd F. Straub
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Physical
Simone G. Weber, David Zahner, Frank Rominger, Bernd F. Straub
Article
Chemistry, Multidisciplinary
T. Sohner, F. Braun, L. C. Over, S. Mehlhose, F. Rominger, B. F. Straub
Article
Chemistry, Inorganic & Nuclear
Stefanie C. Seitz, Frank Rominger, Bernd F. Straub
Article
Chemistry, Multidisciplinary
Oliver Trapp, Saskia Lamour, Frank Maier, Alexander F. Siegle, Kerstin Zawatzky, Bernd F. Straub
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Organic
Timo Soehner, Ina K. Kueppers, Wiebke Wackerow, Frank Rominger, Bernd F. Straub
Article
Chemistry, Multidisciplinary
Florian Beuerle, Anke Krueger, Matthias Lehmann, Thorsten Bach, Uwe Beifuss, Thomas J. J. Mueller, Ralf Giernoth, Klaus Ditrich, Bernd F. Straub, Peter R. Schreiner, Thomas Lindel, Dietrich Boese, Joerg Pietruszka, Roland Pfau, Rolf Breinbauer, Norbert Sewald, Elmar Weinhold, Christoph Arenz, Jennifer Andexer, Michael Mueller, Wolfgang von Deyn, Markus Kordes, Christine Wiebe, Kilian Muniz, Stefan Braese, Mathias O. Senge, Jan Paradies, Burkhard Luy, Claudia Muhle-Goll, Moritz Bosse Biskup
NACHRICHTEN AUS DER CHEMIE
(2013)
Article
Chemistry, Multidisciplinary
Florian Beuerle, Anke Krueger, Matthias Lehmann, Thorsten Bach, Uwe Beifuss, Thomas J. J. Mueller, Mathias O. Senge, Ralf Giernoth, Klaus Ditrich, Jan Paradies, Kilian Muniz, Bernd F. Straub, Peter R. Schreiner, Detlef Schroeder, Thomas Lindel, Joerg Pietruszka, Christoph Soeffing, Roland Pfau, Rolf Breinbauer, Norbert Sewald, Elmar Weinhold, Moritz Bosse Biskup, Gerald Draeger, Christoph Arenz, Jennifer Andexer, Michael Mueller, Wolfgang von Deyn, Trevor Newton, Joachim Rheinheimer, Claudia Muhle-Goll, Burkhard Luy, Stefan Braese
NACHRICHTEN AUS DER CHEMIE
(2012)