The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells

Domain Formation and Permeabilization Induced by the Saponin α-Hederin and Its Aglycone Hederagenin in a Cholesterol-Containing Bilayer

(2014) Joseph Lorent et al.   LANGMUIR

Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study

(2013) Seiichi Sakamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Real-time analysis of membrane permeabilizing effects of oleanane saponins

(2013) Roger Gilabert-Oriol et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Induction of Highly Curved Structures in Relation to Membrane Permeabilization and Budding by the Triterpenoid Saponins, α- and δ-Hederin

(2013) Joseph Lorent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiscale study on the interaction mechanism between ginsenoside biosurfactant and saikosaponin a

(2013) Xingxing Dai et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner

(2012) Linn Oftedal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: A correlation?

(2012) Stefan Böttger et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Adjuvant effect of ginsenoside-based nanoparticles (ginsomes) on the recombinant vaccine against Eimeria tenella in chickens

(2012) De-Fu Zhang et al.   PARASITOLOGY RESEARCH

Lipid raft: A floating island of death or survival

(2012) Kimberly S. George et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ginsenosides as anticancer agents: In vitro and in vivo activities, structure–activity relationships, and molecular mechanisms of action

(2012) Subhasree Ashok Nag   Frontiers in Pharmacology

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Synergism and foaming properties in binary mixtures of a biosurfactant derived from Camellia oleifera Abel and synthetic surfactants

(2011) Hong-lei Jian et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish

(2011) S. Van Dyck et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Surface Rheology of Saponin Adsorption Layers

(2011) R. Stanimirova et al.   LANGMUIR

Apoptosis and membrane permeabilisation induced by macranthoside B on HL-60 cells

(2011) Fuqin Guan et al.   NATURAL PRODUCT RESEARCH

Molecular activities, biosynthesis and evolution of triterpenoid saponins

(2011) Jörg M. Augustin et al.   PHYTOCHEMISTRY

Lipid Rafts and Fas/CD95 Signaling in Cancer Chemotherapy

(2011) Consuelo Gajate et al.   Recent Patents on Anti-Cancer Drug Discovery

Tubular immunostimulating complex based on cucumarioside A2-2 and monogalactosyldiacylglycerol from marine macrophytes

(2011) Eduard Y Kostetsky et al.   JOURNAL OF NANOBIOTECHNOLOGY

Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

(2011) Anil Mahapatro et al.   JOURNAL OF NANOBIOTECHNOLOGY

Characterization of Plant-Derived Saponin Natural Products againstCandida albicans

(2010) Jeffrey J. Coleman et al.   ACS Chemical Biology

Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosis

(2010) Jian Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt

(2010) E-K Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Naturally Occurring Triterpenoid Saponins

(2010) Biswanath Dinda et al.   CHEMISTRY & BIODIVERSITY

Acrosome reaction-related steroidal saponin, Co-ARIS, from the starfish induces structural changes in microdomains

(2010) Masahiro Naruse et al.   DEVELOPMENTAL BIOLOGY

Chemical study and medical application of saponins as anti-cancer agents

(2010) Shuli Man et al.   FITOTERAPIA

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

(2010) Hu   International Journal of Nanomedicine

Resistance in the Plant, Barbarea vulgaris, and Counter-Adaptations in Flea Beetles Mediated by Saponins

(2010) Jens K. Nielsen et al.   JOURNAL OF CHEMICAL ECOLOGY

Nanosuspensions of chemically modified saponins: Reduction of hemolytic side effects and potential tool in drug targeting strategy

(2010) H. Van de Ven et al.   JOURNAL OF CONTROLLED RELEASE

Progress in nanotechnology for healthcare

(2010) V. Raffa et al.   MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES

Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis C. H. Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus)

(2010) Gao-Xue Wang et al.   PARASITOLOGY RESEARCH

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

In Vitro Cutaneous Application of ISCOMs on Human Skin Enhances Delivery of Hydrophobic Model Compounds Through the Stratum Corneum

(2009) Henriette Baun Madsen et al.   AAPS Journal

Phytosterol glycosides reduce cholesterol absorption in humans

(2009) Xiaobo Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cimiside E arrests cell cycle and induces cell apoptosis in gastric cancer cells

(2009) Lian Yu Guo et al.   ARCHIVES OF PHARMACAL RESEARCH

Asparanin A induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

(2009) Wei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption

(2009) Jae-Sung Yi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Membrane Cholesterol by 63 Amphipaths

(2009) Yvonne Lange et al.   BIOCHEMISTRY

Mannosylated saponins based on oleanolic and glycyrrhizic acids. Towards synthetic colloidal antigen delivery systems

(2009) Alison M. Daines et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins

(2009) Charles Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Autophagy Inhibition Enhances Apoptosis Induced by Ginsenoside Rk1 in Hepatocellular Carcinoma Cells

(2009) Hyeonseok KO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The current role of amphotericin B lipid complex in managing systemic fungal infections

(2009) Patrick Chu et al.   CURRENT MEDICAL RESEARCH AND OPINION

Hemolytic mechanism of dioscin proposed by molecular dynamics simulations

(2009) Fu Lin et al.   JOURNAL OF MOLECULAR MODELING

Karaya root saponin exerts a hypocholesterolemic response in rats fed a high-cholesterol diet

(2009) Sadia Afrose et al.   NUTRITION RESEARCH

Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress

(2009) Frank W. King et al.   PLoS One

Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts

(2009) Zhi-Xiang Xu et al.   PLoS One

Amplified immune response by ginsenoside-based nanoparticles (ginsomes)

(2009) Xiaoming Song et al.   VACCINE

Advances in saponin-based adjuvants

(2009) Hong-Xiang Sun et al.   VACCINE

ISCOMs and ISCOMATRIX™

(2009) Hong-Xiang Sun et al.   VACCINE

Selective toxicity of ginsenoside Rg3 on multidrug resistant cells by membrane fluidity modulation

(2008) Hyog-Young Kwon et al.   ARCHIVES OF PHARMACAL RESEARCH

Rewinding the DISC

(2008) Benjamin Chaigne-Delalande et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Comparison of the interaction of tomatine with mixed monolayers containing phospholipid, egg sphingomyelin, and sterols

(2008) Barry W. Walker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ordering effects of cholesterol and its analogues

(2008) Tomasz Róg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of Cholesterol on Physical Properties of Human Erythrocyte Membranes: Impact on Susceptibility to Hydrolysis by Secretory Phospholipase A2

(2008) Anne L. Heiner et al.   BIOPHYSICAL JOURNAL

Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells

(2008) L.-K. Sy et al.   CANCER RESEARCH

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

(2008) J. Montero et al.   CANCER RESEARCH

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Simultaneous removal of phenanthrene and cadmium from contaminated soils by saponin, a plant-derived biosurfactant

(2008) Saisai Song et al.   ENVIRONMENTAL POLLUTION

Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2+ influx and caspase-8 dependent pathways

(2008) Jung-Hye Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of Panax notoginseng

(2008) Jing Xiong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pores Formation on Cell Membranes by Hederacolchiside A1 Leads to a Rapid Release of Proteins for Cytosolic Subproteome Analysis

(2008) Gabriel D. Mazzucchelli et al.   JOURNAL OF PROTEOME RESEARCH

Saponins in Tumor Therapy

(2008) Christopher Bachran et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The γ-aminobutyric acid receptor B, but not the metabotropic glutamate receptor type-1, associates with lipid rafts in the rat cerebellum

(2003) Anja Becher et al.   JOURNAL OF NEUROCHEMISTRY