Review
Biochemistry & Molecular Biology
Meihong Lin, Xiaoyang Bi, Lijuan Zhou, Jiguang Huang
Summary: This paper discusses 116 triterpenoid molecules with insecticidal activity from Meliaceae plants. Among the different genera, the insecticidal activities of plants from Entandrophragma and Melia have gained significant research attention. The chemicals exhibited antifeedant, poisonous, and growth-regulatory activities towards various insect species. Toosendanin was found to be the most effective antifeedant and insect growth-regulatory agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Meihong Lin, Sifan Yang, Jiguang Huang, Lijuan Zhou
Summary: Plant-originated triterpenes are important insecticidal molecules, with molecules from Meliaceae plants showing a variety of insecticidal activities. Among the 102 triterpenoid molecules discussed in the paper, azadirachtin from Azadirachta indica A. Juss is the most well-known and highly effective botanical insecticide. However, it is notable that species from Cedrela also showed insecticidal activity and warrant further study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Emmanuel Laplantine, Christine Chable-Bessia, Anne Oudin, Jitendryia Swain, Adele Soria, Peggy Merida, Manon Gourdelier, Sarra Mestiri, Indira Besseghe, Erwan Bremaud, Aymeric Neyret, Sebastien Lyonnais, Cyril Favard, Philippe Benaroch, Mathieu Hubert, Olivier Schwartz, Maryse Guerin, Anne Danckaert, Elaine Del Nery, Delphine Muriaux, Robert Weil
Summary: This study highlights the potential of Auranofin in inhibiting NF-kappa B pathway to alleviate inflammation, prevent SARS-CoV-2 infection, and counteract key steps of viral entry into host cells.
Article
Biochemistry & Molecular Biology
Erik Wahlen, Frida Olsson, Doroteya Raykova, Ola Soderberg, Johan Heldin, Johan Lennartsson
Summary: This study investigates the internalization process of EGFR and PDGFR-β using immunofluorescent microscopy. The results show that these two receptors utilize separate internalization routes, but merge in a common endosomal compartment after 45 minutes of stimulation. The association between EGFR and caveolin-1 is stronger compared to PDGFR-β, and disruption of lipid rafts affects the signaling of EGFR and PDGFR-β differently.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Hui-Yu Wu, Chia-Jung Kuo, Chia-Huei Chou, Mao-Wang Ho, Chyi-Liang Chen, Tsui-Shan Hsu, Ying-Chu Chen, Chuan Chiang-Ni, Yi-Ywan M. Chen, Cheng-Hsun Chiu, Chih-Ho Lai
Summary: This study investigated the interaction between C. innocuum and lipid rafts and its impact on cell pathogenicity and inflammatory response.
Article
Cell Biology
Sijun Liu, Jun Tao, Fengqi Duan, Huangjing Li, Hongmei Tan
Summary: Lipid rafts play important roles in HHcy-accelerated AS. HHcy promotes lipid raft clustering via upregulation of ASM, which mediates the assembly of the NOX complex, causing an increase in ROS generation, NLRP3 inflammasome activation, and pyroptosis.
Review
Cell Biology
Borui Li, Yi Qin, Xianjun Yu, Xiaowu Xu, Wenyan Yu
Summary: Lipid rafts are specialized membrane domains enriched with cholesterol and sphingolipids, regulating signal receptors to promote signaling cascades important in cancer cell survival, death, and metastasis. The concept of CASMER (cluster of apoptotic signaling molecule-enriched rafts) contributed by F. Mollinedo and C. Gajate highlights the role of lipid rafts in cancer progression, making them potential targets for cancer therapy.
CELL PROLIFERATION
(2022)
Article
Oncology
Beiyuan Hu, Tiantian Zou, Wei Qin, Xiaotian Shen, Yinghan Su, Jianhua Li, Yang Chen, Ze Zhang, Haoting Sun, Yan Zheng, Chao-Qun Wang, Zhengxin Wang, Tian-En Li, Shun Wang, Le Zhu, Xufeng Wang, Yan Fu, Xudong Ren, Qiongzhu Dong, Lun-Xiu Qin
Summary: Lenvatinib, a first-line treatment for hepatocellular carcinoma (HCC), has limited clinical benefits. This study reveals that HCC cells develop resistance to Lenvatinib by activating the EGFR-STAT3-ABCB1 pathway. Combined treatment with erlotinib, an EGFR inhibitor, may overcome acquired resistance and improve the clinical benefit of Lenvatinib.
Review
Cell Biology
Rosa Vona, Elisabetta Iessi, Paola Matarrese
Summary: Cholesterol is crucial for cell membrane structure and plays a key role in regulating cell signaling pathways. Its homeostasis is tightly regulated and dysregulation may be linked to cardiovascular diseases and cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Erik Wahlen, Frida Olsson, Ola Soderberg, Johan Lennartsson, Johan Heldin
Summary: Lipid rafts play a crucial role in connecting cell surface receptors to intracellular signaling pathways. This study investigates the involvement of lipid rafts in receptor tyrosine kinase signaling through the analysis of PDGFR-beta signaling in different cell lines depleted of cholesterol. The results suggest that cell type-specific wiring of signaling pathways can lead to differential sensitivity to cholesterol depletion.
CELLULAR SIGNALLING
(2022)
Article
Immunology
Joy Edwards-Hicks, Petya Apostolova, Joerg M. Buescher, Hannes Maib, Michal A. Stanczak, Mauro Corrado, Ramon I. Klein I. Geltink, Maria Elena Maccari, Matteo Villa, Gustavo E. Carrizo, David E. Sanin, Francesc Baixauli, Beth Kelly, Jonathan D. Curtis, Fabian Haessler, Annette Patterson, Cameron S. Field, George Caputa, Ryan L. Kyle, Melanie Soballa, Minsun Cha, Harry Paul, Jacob Martin, Katarzyna M. Grzes, Lea Flachsmann, Michael Mitterer, Liang Zhao, Frances Winkler, David Ali Rafei-Shamsabadi, Frank Meiss, Bertram Bengsch, Robert Zeiser, Daniel J. Puleston, David O'Sullivan, Edward J. Pearce, Erika L. Pearce
Summary: The authors demonstrate the impact of metabolic alteration on the acyl chain composition on phosphoinositide-driven signaling in CD8(+) T cells. They find that naive T cells are rich in polyunsaturated phosphoinositides, while effector T cells predominantly have saturated fatty acyl chains. The different pools of phosphoinositides play distinct roles in initiating and sustaining effector function in CD8(+) T cell differentiation.
Article
Oncology
So-Yeon Park, Jee-Heun Kim, Jang-Hyun Choi, Choong-Jae Lee, Won-Jae Lee, Sehoon Park, Zee-Yong Park, Jeong-Heum Baek, Jeong-Seok Nam
Summary: This study highlights the important role of lipid rafts (LRs) in colorectal cancer, where an LR-disrupting alkylphospholipid drug can suppress CSC populations and their self-renewal activities. By inhibiting the LR/CHEK1 axis, the drug forces CSCs to enter inappropriate mitosis, leading to catastrophic cell death.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Food Science & Technology
Shamish Ganpule, Akshay Kumar Vijaya, Aleksandra Sukova, Giulio Preta
Summary: This paper investigates the inverse correlation between cholesterol-dependent toxins pneumolysin and melittin. The toxicity of pneumolysin can be reduced by depleting cholesterol, while melittin's toxicity increases after cholesterol depletion. The use of simvastatin also leads to a similar response.
Article
Pharmacology & Pharmacy
Xiangyun Tian, Junjie Zhang, Shaowen Wang, Huan Gao, Yi Sun, Xiaoqian Liu, Wei Fu, Bo Tan, Ruibin Su
Summary: This study investigated the effects of Y7.43 mutation on the signaling pathways of MOR using molecular docking and molecular dynamics simulations. The results showed that Y7.43 mutation reduced the activation of the G(i/o) protein pathway, blocked the recruitment of ss-arrestin2, increased the outward movement of H6 in MOR, and disrupted hydrophobic interactions. These findings are important for the design of new drugs and the optimization of synthesized compound structures.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Zhijun Wu, Xingzhi Li, Dexuan Guo, Pengfei Li, Yating Zhang, Dehua Zou, Xianhe Wang, Jiaxin Xu, Xuening Wu, Yujiang Shen, Yuchang Li, Lili Yao, Li Liyang, Lijie Xiao, Baifen Song, Jinzhu Ma, Xinyang Liu, Shuyan Xu, Xin Xu, Hua Zhang, Liang Zheng, Hongwei Cao
Summary: The integrity of lipid rafts is essential for the activation of PI3K/Akt signaling during both early and late stages of CA16 infection. This signaling pathway plays a crucial role in facilitating virus replication by mediating SREBP1 maturation. Additionally, the study indicates that PI3K/Akt signaling and SREBP1 may have contrasting effects on virus replication in different stages of infection.
VETERINARY MICROBIOLOGY
(2021)