Article
Psychiatry
Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan
Summary: This study directly examined the relationship between the metabotropic glutamate receptor 5 (mGluR5) and glutamate or GABA in the human brain of autistic individuals. The results showed that autistic individuals had significantly higher mGluR5 binding in a specific region, and there was a strong negative correlation between GABA and mGluR5 density. These findings suggest that an increase in mGluR5 in autism may relate to GABAergic interneuron abnormalities.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Vanessa Pereira, Juri Aparicio Arias, Amadeu Llebaria, Cyril Goudet
Summary: Neuropathic pain is a challenging condition to manage. In this study, the role of the amygdala in regulating neuropathic pain was investigated. The activation of mGlu4 receptors in the amygdala was found to alleviate sensory and depressive-like symptoms in a mouse model of neuropathy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carlos Alberto Castillo, Inmaculada Ballesteros-Yanez, David Agustin Leon-Navarro, Jose Luis Albasanz, Mairena Martin
Summary: The amyloid beta peptide plays a central role in Alzheimer's disease pathology. Exposure to A beta(25-35) in rat cortical neurons increased mGluR density and affinity, along with up-regulation of adenosine A(1)R and A(2A)R. The study highlights the possible involvement of metabotropic glutamate and adenosine receptors in the early events of AD physiopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Ananth Prasad Burada, Rajesh Vinnakota, Bertrand Lambolez, Ludovic Tricoire, Janesh Kumar
Summary: Enigmatic orphan glutamate delta receptors (GluD) are a type of ionotropic glutamate receptors (iGluRs) that do not bind glutamate or evoke currents when binding glycine and D-serine. They are believed to function as structural proteins that facilitate synapse formation, maturation, and maintenance in the hippocampus and cerebellum. Recent research suggests that GluD receptors have interactions with metabotropic glutamate receptors (mGlus) and are gated by their activation, with new tools and structures helping to define their role in synaptic physiology.
Article
Reproductive Biology
Alexandra Spirkova, Veronika Kovarikova, Zuzana Sefcikova, Jozef Pisko, Martina Ksinanova, Juraj Koppel, Dusan Fabian, Stefan Cikos
Summary: The study reveals that glutamic acid can affect preimplantation embryo development through cell membrane receptors. High extracellular concentrations of glutamic acid can inhibit blastocyst development, which is of practical significance.
BIOLOGY OF REPRODUCTION
(2022)
Review
Pharmacology & Pharmacy
Ananth Prasad Burada, Rajesh Vinnakota, Pratibha Bharti, Priyanka Dutta, Neelima Dubey, Janesh Kumar
Summary: GluD receptors are a subfamily of ionotropic glutamate receptors that play a crucial role in synapse formation, maturation, and maintenance of central nervous system functions. Despite the lack of knowledge about their endogenous ligands, significant discoveries have been made regarding their role in mediating trans-synaptic interactions and their unique non-swapped architecture. Additionally, the prospect of GluD ionotropic activity being regulated by direct interaction with metabotropic glutamate receptors is exciting.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Reuben Levy-Myers, Daniel Daudelin, Chan Hyun Na, Shanthini Sockanathan
Summary: This study demonstrates that the protein GDE3 regulates actin remodeling to release a unique subtype of extracellular vesicles (EVs) with distinct functions. GDE3 is expressed in astrocytes but not neurons and is responsible for releasing EVs containing annexin A1 and GDE3 via the protein WAVE3. Mice lacking GDE3 show decreased miniature excitatory postsynaptic current amplitudes in hippocampal neurons.
Review
Biochemistry & Molecular Biology
Johanna Detzner, Gottfried Pohlentz, Johannes Muthing
Summary: This review discusses the clinical impact of Enterohemorrhagic Escherichia coli (EHEC) infections, focusing on the vesicular packaging of Shiga toxin (Stx) in the intestine and blood stream, as well as the extraintestinal complications and therapeutic options. The role of epithelial cells of the colon and kidneys in the infection process is also addressed. The review highlights the importance of Stx-binding glycosphingolipids (Gb3Cer and Gb4Cer) and their distribution in primary human kidney and colon epithelial cells. The susceptibility of primary renal and colonic epithelial cells to Stx is discussed, suggesting a resilience of the intestinal epithelium against the human-pathogenic Stx subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chaohong Li, Baosheng Zhao, Chenlu Zhao, Lu Huang, Yuzhen Liu
Summary: The study revealed the expression and physiological function of mGluR1 in the CB. Activation of mGluR1 inhibited the response of CB to hypoxia and prolonged the latency period of the response.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Prachi Ojha, Subhajit Pal, Samarjit Bhattacharyya
Summary: Norbin protein plays a critical role in the internalization process of Group I mGluRs and may be associated with mGluR-mediated synaptic plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Caroline S. S. Johnson, Paul E. Micevych, Paul G. G. Mermelstein
Summary: Recent studies have shown that traditional estrogen receptors, alpha and beta, can also act at the cell surface in addition to their nuclear functions. Signaling from these membrane-bound estrogen receptors can rapidly affect cellular excitability and ultimately impact gene expression. The interaction between these membrane receptors and metabotropic glutamate receptors (mGluRs) plays a key role in various female functions such as reproduction and motivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Stephen W. White, Gwendolyn D. Squires, Sequioa J. Smith, Gwendolyn M. Wright, Kenneth J. Sufka, John M. Rimoldi, Rama S. Gadepalli
Summary: Research on modulation of glutamate receptors in aves under stress models shows potential clinical value in treating panic disorder and treatment-resistant depression.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Arthur Cardoso Souto, Matheus Heidemann Tempone, Lyslie Azeredo Coutinho Goncalves, Vladimir Pedro Peralva Borges-Martins, Maria Carolina Peixoto-Rodrigues, Ana Clara Oliveira Damascena, Gabriel Ferraz, Alex Christian Manhaes, Newton Goncalves Castro, Ricardo Augusto de Melo Reis, Ana Lucia Marques Ventura, Regina Celia Cussa Kubrusly
Summary: Nicotine influences the development of avian embryo retina by reducing GABA uptake and increasing release through NMDAR and PKC pathways, as well as promoting calcium influx.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
M. Angela Cenci, Katrine Skovgard, Per Odin
Summary: Dopamine replacement therapy is the most effective treatment for Parkinson's disease, but it is limited by its side effects. Recent evidence suggests that altered dopamine transmission affects non-dopaminergic neurotransmitter systems in the brain. Researchers are exploring drugs that target non-dopaminergic receptors to improve the side effects of dopamine replacement therapy. This review discusses the different non-dopaminergic targets that have been studied, with a particular focus on modulators of glutamatergic and serotonergic transmission.
Article
Pharmacology & Pharmacy
Wen-Qiang Ge, Ou-Yang Zhan-Mu, Chao Chen, Hong Zhang, Xiao-Yu Wang, Xin Liu, Li Li, Yu-Ye Lan, Chen-Nan Li, Jia-Can Sun, Run-Lin Shi, Zi-Yue Dou, Hui-Lin Pan, Hong-Ping Li, Xiang-Hong Jing, Man Li
Summary: Electroacupuncture (EA) reduces chronic itch by activating CB1 receptors on glutamatergic neurons and inhibiting CB1 receptors on GABAergic neurons in the vlPAG, thereby reducing the release of 5-HT in the medulla oblongata and GRPR signaling in the spinal cord. This study advances our understanding of the therapeutic mechanisms of EA on chronic itch and guides the selection of optimal parameters and acupoints for treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
A. P. S. Hungin, A. Becher, B. Cayley, J. J. Heidelbaugh, J. W. M. Muris, G. Rubin, B. Seifert, A. Russell, N. J. De Wit
NEUROGASTROENTEROLOGY AND MOTILITY
(2015)
Review
Gastroenterology & Hepatology
A. Becher, J. Dent
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2011)
Review
Gastroenterology & Hepatology
H. El-Serag, A. Becher, R. Jones
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2010)
Review
Gastroenterology & Hepatology
A. Becher, H. El-Serag
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2011)
Review
Gastroenterology & Hepatology
J. Tack, A. Becher, C. Mulligan, D. A. Johnson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2012)
Review
Gastroenterology & Hepatology
John Dent, Anja Becher, Joseph Sung, Duowu Zou, Lars Agreus, Franco Bazzoli
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2012)
Review
Gastroenterology & Hepatology
Nimish B. Vakil, Katarina Halling, Anja Becher, Anna Ryden
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2013)
Article
Critical Care Medicine
Klaus Markstaller, Annette Rudolph, Jens Karmrodt, Hendrik W. Gervais, Rolf Goetz, Anja Becher, Matthias David, Oliver S. Kempski, Hans-Ulrich Kauczor, Wolfgang F. Dick, Balthasar Eberle
Review
Ophthalmology
Caroline R. Baumal, Torben Lykke Sorensen, Helene Karcher, Rita L. Freitas, Anja Becher, Sebastien Balez, Andreas Clemens, Michael Singer, Laurent Kodjikian
Summary: This review summarized real-world efficacy and safety data on brolucizumab in patients with neovascular age-related macular degeneration (nAMD). The results showed significant improvements in best corrected visual acuity (BCVA) and central subfield thickness (CST) after brolucizumab treatment, as well as prolonged treatment intervals in switch eyes.
ACTA OPHTHALMOLOGICA
(2023)
Review
Cardiac & Cardiovascular Systems
Uwe Zeymer, Anja Becher, Em Jennings, Saga Johansson, Mogens Westergaard
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2017)
Article
Cell Biology
SV Yelamanchili, C Reisinger, A Becher, S Sikorra, H Bigalke, T Binz, G Ahnert-Hilger
EUROPEAN JOURNAL OF CELL BIOLOGY
(2005)
Article
Biochemistry & Molecular Biology
A Becher, A Green, AO Ige, A Wise, JH White, RAJ McIlhinney
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2004)
Article
Biochemistry & Molecular Biology
C Reisinger, SV Yelamanchili, B Hinz, D Mitter, A Becher, H Bigalke, G Ahnert-Hilger
JOURNAL OF NEUROCHEMISTRY
(2004)
Article
Cell Biology
B Hinz, A Becher, D Mitter, K Schulze, U Heinemann, A Draguhn, G Ahnert-Hilger
EUROPEAN JOURNAL OF CELL BIOLOGY
(2001)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)