Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets
出版年份 2014 全文链接
标题
Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets
作者
关键词
-
出版物
ORAL DISEASES
Volume 21, Issue 1, Pages e25-e50
出版商
Wiley
发表日期
2014-07-24
DOI
10.1111/odi.12275
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Cyclic nucleotide phosphodiesterases (PDEs): coincidence detectors acting to spatially and temporally integrate cyclic nucleotide and non-cyclic nucleotide signals: Figure 1
- (2014) Donald H. Maurice et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells
- (2014) Kenichi Hiramoto et al. CELLULAR SIGNALLING
- The effectiveness and safety of avanafil for erectile dysfunction: a systematic review and meta-analysis
- (2014) Hongtao Wang et al. CURRENT MEDICAL RESEARCH AND OPINION
- Cyclic nucleotide-based therapeutics for chronic obstructive pulmonary disease
- (2014) Mark A Giembycz et al. CURRENT OPINION IN PHARMACOLOGY
- Management of Benign Prostatic Hyperplasia: Role of Phosphodiesterase-5 Inhibitors
- (2014) M. Gacci et al. DRUGS & AGING
- Advances in targeting cyclic nucleotide phosphodiesterases
- (2014) Donald H. Maurice et al. NATURE REVIEWS DRUG DISCOVERY
- Apremilast: welcome advance in treatment of psoriatic arthritis
- (2014) Oliver FitzGerald Nature Reviews Rheumatology
- Structural basis for the design of selective phosphodiesterase 4B inhibitors
- (2013) David Fox et al. CELLULAR SIGNALLING
- How Phosphodiesterase 4 Inhibitors Work in Patients with Chronic Obstructive Pulmonary Disease of the Severe, Bronchitic, Frequent Exacerbator Phenotype
- (2013) Mark A. Giembycz et al. CLINICS IN CHEST MEDICINE
- Genetic Deletion and Pharmacological Inhibition of Phosphodiesterase 10A Protects Mice From Diet-Induced Obesity and Insulin Resistance
- (2013) A. R. Nawrocki et al. DIABETES
- A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice
- (2013) Emilia Guirguis et al. ENDOCRINOLOGY
- Comparative Effectiveness and Safety of Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction: A Systematic Review and Network Meta-analysis
- (2013) JinQiu Yuan et al. EUROPEAN UROLOGY
- New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders
- (2013) Maliheh Safavi et al. Expert Opinion on Drug Discovery
- Emerging therapies for rheumatoid arthritis
- (2013) Peggy Jacques et al. EXPERT OPINION ON EMERGING DRUGS
- PDE4 as a target for cognition enhancement
- (2013) Wito Richter et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease
- (2013) Louisa CY Lee et al. Future Medicinal Chemistry
- Tadalafil - a therapeutic option in the management of BPH-LUTS
- (2013) C. C. Carson et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
- (2013) Peter J. Barnes JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases
- (2013) Marco Conti et al. JOURNAL OF GENERAL PHYSIOLOGY
- DISC1–ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1
- (2013) T Soda et al. MOLECULAR PSYCHIATRY
- Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers
- (2013) D.-C. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphodiesterase-8A binds to and regulates Raf-1 kinase
- (2013) K. M. Brown et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cilostazol for Primary Prevention of Stroke in Peripheral Artery Disease: A Population-based Longitudinal Study in Taiwan
- (2013) Wen-Hsien Lee et al. THROMBOSIS RESEARCH
- Targeting phosphodiesterase 3B enhances cisplatin sensitivity in human cancer cells
- (2013) Katsuhiro Uzawa et al. Cancer Medicine
- Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials
- (2013) Lui G Franciosi et al. Lancet Respiratory Medicine
- Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells
- (2013) Hongli Dong et al. SpringerPlus
- Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis
- (2012) Hane Lee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Evaluation of PDE5 and PDE9 Expression in Benign and Malignant Breast Tumors
- (2012) Fatemeh Karami-Tehrani et al. ARCHIVES OF MEDICAL RESEARCH
- The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia
- (2012) Ginny D. Ho et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication
- (2012) J. W. Stevens et al. BRITISH JOURNAL OF SURGERY
- Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
- (2012) Sung-Jun Park et al. CELL
- Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases
- (2012) Alessandra Ghigo et al. CIRCULATION
- Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart
- (2012) Sanja Beca et al. CIRCULATION RESEARCH
- Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours
- (2012) Anya Rothenbuhler et al. CLINICAL ENDOCRINOLOGY
- EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study
- (2012) B. Vellas et al. Current Alzheimer Research
- Selective PDE inhibitors as novel treatments for respiratory diseases
- (2012) Clive P Page et al. CURRENT OPINION IN PHARMACOLOGY
- PDE Inhibition and cognition enhancement
- (2012) Arjan Blokland et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes
- (2012) F. Ahmad et al. HORMONE AND METABOLIC RESEARCH
- Phosphodiesterases in neurodegenerative disorders
- (2012) Eva Bollen et al. IUBMB LIFE
- Characterization of Conformational Changes and Protein-Protein Interactions of Rod Photoreceptor Phosphodiesterase (PDE6)
- (2012) Suzanne L. Matte et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Critical role for PDE4 subfamilies in the development of experimental autoimmune encephalomyelitis
- (2012) Cristina Sanabra et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus
- (2012) E. F. M. Wouters et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors
- (2012) Michelle M. Claffey et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design
- (2012) Fei Meng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tadalafil for the Treatment of Pulmonary Arterial Hypertension
- (2012) Ronald J. Oudiz et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF
- (2012) S S Pullamsetti et al. ONCOGENE
- K-134, a Phosphodiesterase 3 Inhibitor, Prevents Brain Damage by Inhibiting Thrombus Formation in a Rat Cerebral Infarction Model
- (2012) Hideo Yoshida et al. PLoS One
- Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation
- (2011) Kirsty F. MacKenzie et al. BIOCHEMICAL JOURNAL
- Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
- (2011) Klaus F. Rabe BRITISH JOURNAL OF PHARMACOLOGY
- Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
- (2011) Thérèse Keravis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/ -Catenin-Mediated Transcription in Human Breast Tumor Cells
- (2011) H. N. Tinsley et al. Cancer Prevention Research
- cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes
- (2011) Alessandra Stangherlin et al. CIRCULATION RESEARCH
- Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current
- (2011) Sanja Beca et al. CIRCULATION RESEARCH
- PDE inhibitors: a new approach to treat metabolic syndrome?
- (2011) Claire Lugnier CURRENT OPINION IN PHARMACOLOGY
- The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis
- (2011) Li-Chun Lisa Tsai et al. CURRENT OPINION IN PHARMACOLOGY
- PDE1 isozymes, key regulators of pathological vascular remodeling
- (2011) Stefan Chan et al. CURRENT OPINION IN PHARMACOLOGY
- PDE5 inhibitors: targeting erectile dysfunction in diabetics
- (2011) Sharron H Francis et al. CURRENT OPINION IN PHARMACOLOGY
- PDE3 inhibition in dilated cardiomyopathy
- (2011) Matthew Movsesian et al. CURRENT OPINION IN PHARMACOLOGY
- Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment
- (2011) Isaac Levy et al. CURRENT OPINION IN PHARMACOLOGY
- PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia
- (2011) Jan Kehler et al. CURRENT PHARMACEUTICAL DESIGN
- A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells
- (2011) Lindsay S. Wilson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins
- (2011) Najma Begum et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice
- (2011) Jérôme Leroy et al. JOURNAL OF CLINICAL INVESTIGATION
- Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors
- (2011) Michael S. Malamas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes
- (2011) Y.Y. Sin et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- AKAPs: The architectural underpinnings of local cAMP signaling
- (2011) Michael D. Kritzer et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Reorganized PKA-AKAP associations in the failing human heart
- (2011) Thin-Thin Aye et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Are Phosphodiesterase Type 5 Inhibitors Associated with Vision‐Threatening Adverse Events? A Critical Analysis and Review of the Literature
- (2011) Faris Azzouni et al. Journal of Sexual Medicine
- Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients
- (2011) Malgorzata Labuda et al. MEDIATORS OF INFLAMMATION
- Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ
- (2011) Alessia Perino et al. MOLECULAR CELL
- Intra-Cellular Therapies and Takeda to develop PDE1 inhibitors for schizophrenia
- (2011) NATURE REVIEWS DRUG DISCOVERY
- The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
- (2011) P.H. Hutson et al. NEUROPHARMACOLOGY
- Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice
- (2011) Tatiana V. Lipina et al. NEUROPHARMACOLOGY
- Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
- (2011) Sharron H. Francis et al. PHYSIOLOGICAL REVIEWS
- Efficacy of Cilostazol in reducing restenosis in patients undergoing contemporary stent based PCI: a meta-analysis of randomised controlled trials
- (2011) Umesh Tamhane et al. EuroIntervention
- Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells
- (2010) Yujun Cai et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Should bisphosphonates be used for long-term treatment of glucocorticoid-induced osteoporosis?
- (2010) Steven L. Teitelbaum et al. ARTHRITIS AND RHEUMATISM
- Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction
- (2010) Stefan Ückert et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Female infertility in PDE3A-/-mice
- (2010) Weixing Shen et al. CELL CYCLE
- The Phosphodiesterase Inhibitor Cilostazol Induces Regression of Carotid Atherosclerosis in Subjects With Type 2 Diabetes Mellitus
- (2010) Naoto Katakami et al. CIRCULATION
- New drug therapies for multiple sclerosis
- (2010) Arturo Mangas et al. CURRENT OPINION IN NEUROLOGY
- Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs
- (2010) Therese Keravis et al. CURRENT PHARMACEUTICAL DESIGN
- Phosphodiesterase Inhibitors as Potential Cognition Enhancing Agents
- (2010) Christopher Schmidt CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Salivary epithelial cells: An unassuming target site for gene therapeutics
- (2010) Paola Perez et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Cyclic nucleotide phosphodiesterase 7B mRNA: An unfavorable characteristic in chronic lymphocytic leukemia
- (2010) Lingzhi Zhang et al. INTERNATIONAL JOURNAL OF CANCER
- Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability
- (2010) Sarah N. Rampersad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- cAMP-stimulated Protein Phosphatase 2A Activity Associated with Muscle A Kinase-anchoring Protein (mAKAP) Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-specific Phosphodiesterase PDE4D3
- (2010) Kimberly L. Dodge-Kafka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Update in New Anabolic Therapies for Osteoporosis
- (2010) Ernesto Canalis JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Phosphodiesterase 11A (PDE11A) Genetic Variants May Increase Susceptibility to Prostatic Cancer
- (2010) Fabio Rueda Faucz et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused byPRKAR1AMutations:PDE11AMay Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype
- (2010) Rossella Libé et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/ -Arrestin/cAMP Phosphodiesterase 4 Complex
- (2010) E. Bjorgo et al. MOLECULAR AND CELLULAR BIOLOGY
- How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
- (2010) Madson Q. Almeida et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains
- (2010) Himabindu Penmatsa et al. MOLECULAR BIOLOGY OF THE CELL
- The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland
- (2010) L.-C. L. Tsai et al. MOLECULAR PHARMACOLOGY
- AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
- (2010) F. Donelson Smith et al. NATURE CELL BIOLOGY
- cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
- (2010) S. H. Francis et al. PHARMACOLOGICAL REVIEWS
- Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease
- (2010) Carmela Giampà et al. PLoS One
- Vinpocetine as a potent antiinflammatory agent
- (2010) A. E. Medina PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
- (2010) C. M. Adamo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vinpocetine inhibits NF- B-dependent inflammation via an IKK-dependent but PDE-independent mechanism
- (2010) K.-I. Jeon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the β3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes
- (2009) Faiyaz Ahmad et al. BIOCHEMICAL JOURNAL
- Phosphodiesterase 3 and 4 Negatively Regulate Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Formation by Prostaglandin E2
- (2009) A Long Sae Mi Noh et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3′, 5′-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells
- (2009) Yoshihiro Nakao et al. BONE
- Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease
- (2009) Katharine H Banner et al. BRITISH JOURNAL OF PHARMACOLOGY
- Functional Phosphodiesterase 11A Mutations May Modify the Risk of Familial and Bilateral Testicular Germ Cell Tumors
- (2009) Anelia Horvath et al. CANCER RESEARCH
- PTH and PTHrP signaling in osteoblasts
- (2009) Nabanita S. Datta et al. CELLULAR SIGNALLING
- Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy
- (2009) Clint L. Miller et al. CIRCULATION RESEARCH
- Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte
- (2009) R. P. Norris et al. DEVELOPMENT
- Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B
- (2009) Ren Zhang et al. ENDOCRINOLOGY
- Targeting cancer with phosphodiesterase inhibitors
- (2009) Rajkumar Savai et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma
- (2009) Yukio Yamano et al. INTERNATIONAL JOURNAL OF CANCER
- Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets
- (2009) Roger W. Hunter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Cardiac IKsPotassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3
- (2009) Cecile Terrenoire et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Local delivery of rolipram, a phosphodiesterase-4-specific inhibitor, augments bone morphogenetic protein-induced bone formation
- (2009) Yoshio Tokuhara et al. JOURNAL OF BONE AND MINERAL METABOLISM
- Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
- (2009) Leonardo M Fabbri et al. LANCET
- Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood—brain barrier disruption in multiple sclerosis
- (2009) Bibiana Bielekova et al. Multiple Sclerosis Journal
- Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
- (2009) Alex B Burgin et al. NATURE BIOTECHNOLOGY
- Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons
- (2009) Katherine D Cygnar et al. NATURE NEUROSCIENCE
- Phosphodiesterase Type 5 Inhibitors for Pulmonary Arterial Hypertension
- (2009) Stephen L. Archer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
- (2009) Emily J. Tsai et al. PHARMACOLOGY & THERAPEUTICS
- Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity
- (2009) E. Puxeddu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
- (2009) J. Pandit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights
- (2009) Clemens C. Heikaus et al. STRUCTURE
- Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
- (2009) Miles D. Houslay TRENDS IN BIOCHEMICAL SCIENCES
- Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma
- (2009) Toshiyuki Kita et al. ALLERGOLOGY INTERNATIONAL
- Involvement of phosphodiesterase 4 in β-adrenoceptor agonist-induced amylase release in parotid acinar cells
- (2009) Keitaro Satoh et al. Journal of Oral Science
- Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity†‡
- (2008) Huanchen Wang et al. BIOCHEMISTRY
- Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)
- (2008) Daniel M. Collins et al. CELLULAR SIGNALLING
- Phosphodiesterase 11A (PDE11A) and Genetic Predisposition to Adrenocortical Tumors
- (2008) R. Libe et al. CLINICAL CANCER RESEARCH
- Nitric oxide: novel therapy for osteoporosis
- (2008) Sunil J Wimalawansa EXPERT OPINION ON PHARMACOTHERAPY
- Phosphodiesterase inhibition in heart failure
- (2008) Matthew Movsesian et al. HEART FAILURE REVIEWS
- Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5
- (2008) Clemens C. Heikaus et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Allosteric Regulation between the GAF Domain and Catalytic Domain of Photoreceptor Phosphodiesterase PDE6
- (2008) Xiu-Jun Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2
- (2008) Hiromi Sano et al. JOURNAL OF NEUROCHEMISTRY
- Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease
- (2008) Zena DeMarch et al. NEUROBIOLOGY OF DISEASE
- Mutation inPDE8B,a Cyclic AMP–Specific Phosphodiesterase in Adrenal Hyperplasia
- (2008) Anelia Horvath et al. NEW ENGLAND JOURNAL OF MEDICINE
- Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions
- (2008) L. S. Wilson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for the catalytic mechanism of human phosphodiesterase 9
- (2008) S. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia
- (2008) L. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective phosphodiesterase inhibitors: a promising target for cognition enhancement
- (2008) Olga A. H. Reneerkens et al. PSYCHOPHARMACOLOGY
- PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia
- (2008) S. Hossein Fatemi et al. SCHIZOPHRENIA RESEARCH
- Signal transducing membrane complexes of photoreceptor outer segments
- (2008) Theodore G. Wensel VISION RESEARCH
- Diminished Phosphodiesterase-8B Potentiates Biphasic Insulin Response to Glucose
- (2007) Avital Dov et al. ENDOCRINOLOGY
- Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation
- (2007) J. Creighton et al. JOURNAL OF CELL SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search