Genetic alterations of protein tyrosine phosphatases in human cancers

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications

(2015) Yunyun Jiang et al.   Oncotarget

A Novel Molecular Diagnostic of Glioblastomas: Detection of an Extracellular Fragment of Protein Tyrosine Phosphatase μ

(2015) Susan M. Burden-Gulley et al.   NEOPLASIA

PTP-Pez: A novel regulator of TGFβ signaling

(2014) Leila Wyatt et al.   CELL CYCLE

Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis

(2014) Z. Liu et al.   CLINICAL CANCER RESEARCH

A Protease Storm Cleaves a Cell-Cell Adhesion Molecule in Cancer: Multiple Proteases Converge to Regulate PTPmu in Glioma Cells

(2014) Polly J. Phillips-Mason et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

(2014) Sam Behjati et al.   NATURE GENETICS

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma

(2014) Jay Gunawardana et al.   NATURE GENETICS

PTPRT Regulates High-Fat Diet-Induced Obesity and Insulin Resistance

(2014) Xiujing Feng et al.   PLoS One

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis

(2014) B. Ortiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

(2014) V. W. Y. Lui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue

(2013) So-Hee Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

High-resolution loss of heterozygosity screening implicatesPTPRJas a potential tumor suppressor gene that affects susceptibility to non-hodgkin's lymphoma

(2013) Carlos Aya-Bonilla et al.   GENES CHROMOSOMES & CANCER

Fas-associated Phosphatase 1 (Fap1) Influences βCatenin Activity in Myeloid Progenitor Cells Expressing the Bcr-abl Oncogene

(2013) Weiqi Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of a Tumor-associated Activating Mutation in Protein Tyrosine PhosphatasePtpn11(Shp2) Enhances Mitochondrial Metabolism, Leading to Oxidative Stress and Senescence

(2013) Hong Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

(2013) Shom Goel et al.   JNCI-Journal of the National Cancer Institute

Shale gas: Pollution fears in China

(2013) Hong Yang et al.   NATURE

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

(2013) Shafi Kuchay et al.   NATURE CELL BIOLOGY

Tumor Derived Mutations of Protein Tyrosine Phosphatase Receptor Type K Affect Its Function and Alter Sensitivity to Chemotherapeutics in Glioma

(2013) Supreet Agarwal et al.   PLoS One

The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity

(2013) Chrysiis Michaloglou et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

(2013) Makoto Hayashi et al.   Nature Communications

Isolation and Functional Characterization of Peptide Agonists of PTPRJ, a Tyrosine Phosphatase Receptor Endowed with Tumor Suppressor Activity

(2012) Francesco Paduano et al.   ACS Chemical Biology

The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non–Small Cell Lung Cancer

(2012) Marianna Scrima et al.   AMERICAN JOURNAL OF PATHOLOGY

PTPN13/PTPL1: An Important Regulator of Tumor Aggressiveness

(2012) Gilles Freiss et al.   Anti-Cancer Agents in Medicinal Chemistry

Protein Tyrosine Phosphatase Shp2 (Ptpn11) Plays an Important Role in Maintenance of Chromosome Stability

(2012) X. Liu et al.   CANCER RESEARCH

Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1

(2012) Ogan D. Abaan et al.   EXPERIMENTAL CELL RESEARCH

Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA-328

(2012) Francesco Paduano et al.   FEBS Journal

PTPN14 is required for the density-dependent control of YAP1

(2012) W. Wang et al.   GENES & DEVELOPMENT

Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT

(2012) A.-R. Park et al.   JOURNAL OF CELL SCIENCE

Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer

(2012) Izabela Laczmanska et al.   JOURNAL OF HUMAN GENETICS

The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma

(2012) Silvia Casagrande et al.   JOURNAL OF PATHOLOGY

Fas-associated phosphatase 1 mediates Fas resistance in myeloid progenitor cells expressing the Bcr–abl oncogene

(2012) Weiqi Huang et al.   LEUKEMIA & LYMPHOMA

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

(2012) Maria Meehan et al.   Molecular Cancer

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis

(2012) N Hagemann et al.   ONCOGENE

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14

(2012) J-M Huang et al.   ONCOGENE

PTPN14 interacts with and negatively regulates the oncogenic function of YAP

(2012) X Liu et al.   ONCOGENE

Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14

(2012) P Zhang et al.   ONCOGENE

ErbB2, EphrinB1, Src Kinase and PTPN13 Signaling Complex Regulates MAP Kinase Signaling in Human Cancers

(2012) Paola D. Vermeer et al.   PLoS One

PTPN11-Associated Mutations in the Heart: Has LEOPARD Changed Its RASpots?

(2012) Jessica Lauriol et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling

(2011) Deepika Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cross-talk between Phospho-STAT3 and PLC 1 Plays a Critical Role in Colorectal Tumorigenesis

(2011) P. Zhang et al.   MOLECULAR CANCER RESEARCH

Should I stay or should I go? Shedding of RPTPs in cancer cells switches signals from stabilizing cell-cell adhesion to driving cell migration

(2011) Polly J. Phillips-Mason et al.   Cell Adhesion & Migration

Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome

(2011) Margot E. Bowen et al.   PLoS Genetics

Protein Tyrosine Phosphatase PTPN14 Is a Regulator of Lymphatic Function and Choanal Development in Humans

(2010) Audrey C. Au et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5

(2010) Yong-Sam Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of the Protein-Tyrosine Phosphatase DEP-1/PTPRJ Drives Meningioma Cell Motility

(2010) Astrid Petermann et al.   BRAIN PATHOLOGY

Cancer Cells Cut Homophilic Cell Adhesion Molecules and Run

(2010) Sonya E.L. Craig et al.   CANCER RESEARCH

Cancer-Derived Mutations in the Fibronectin III Repeats of PTPRT/PTPρ Inhibit Cell-Cell Aggregation

(2010) Peng Zhang et al.   CELL COMMUNICATION AND ADHESION

Characterization of the Adhesive Properties of the Type IIb Subfamily Receptor Protein Tyrosine Phosphatases

(2010) Scott Becka et al.   CELL COMMUNICATION AND ADHESION

Protein kinase signaling networks in cancer

(2010) John Brognard et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Germline Epigenetic Silencing of the Tumor Suppressor Gene PTPRJ in Early-Onset Familial Colorectal Cancer

(2010) Ramprasath Venkatachalam et al.   GASTROENTEROLOGY

High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma

(2010) Maciej Giefing et al.   GENES CHROMOSOMES & CANCER

FAP-1 and NF-κB expressions in oral squamous cell carcinoma as potential markers for chemo-radio sensitivity and prognosis

(2010) Y. Nariai et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration

(2010) Polly J. Phillips-Mason et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1

(2010) Robert Schickel et al.   MOLECULAR CELL

Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T

(2010) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTP1B: a double agent in metabolism and oncogenesis

(2010) Shu-Chin Yip et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells

(2009) Jasminka Omerovic et al.   BIOCHEMICAL JOURNAL

Proteolytic Cleavage of Protein Tyrosine Phosphatase   Regulates Glioblastoma Cell Migration

(2009) A. M. Burgoyne et al.   CANCER RESEARCH

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

(2009) Sofie Mellberg et al.   FASEB JOURNAL

VE-PTP controls blood vessel development by balancing Tie-2 activity

(2009) Mark Winderlich et al.   JOURNAL OF CELL BIOLOGY

Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway

(2009) A C Hoover et al.   ONCOGENE

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic β-catenin and affects membrane distribution of β-catenin/E-cadherin complexes in cancer cells

(2008) Luisa Novellino et al.   CELLULAR SIGNALLING

Expression of the putative tumor suppressor genePTPN13/PTPL1is an independent prognostic marker for overall survival in breast cancer

(2008) Françoise Révillion et al.   INTERNATIONAL JOURNAL OF CANCER

BCCIP associates with the receptor protein tyrosine phosphatase PTPµ

(2008) Polly J. Phillips-Mason et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tumor-Derived Extracellular Mutations of PTPRT/PTP  Are Defective in Cell Adhesion

(2008) J. Yu et al.   MOLECULAR CANCER RESEARCH