Article
Oncology
Shu-Guang Zhou, Dai-Fei Wu, Hui Yao, Wei-Yu Zhang, Feng-Jiao Tian, Guo Chen, Chun-Fa Zhang
Summary: This study demonstrates that REBACIN (R) can effectively inhibit the growth of cervical cancer cells by targeting HPV E6/E7 expression, leading to the clearance of persistent hrHPV infections. In vitro experiments show that REBACIN (R) treatment prevents the growth of cervical cancer cells containing E6/E7 oncogenes and inhibits E6/E7 expression. Clinical validation shows that REBACIN (R) treatment leads to a higher clearance rate of HPV E6/E7 mRNA compared to the control groups, confirming the efficacy of REBACIN (R) in clearing persistent hrHPV infections by inhibiting HPV E6/E7 oncogenes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tingting Yu, Chunyan Wang
Summary: This study divided 300 patients with cervical lesions into different groups and found that the detection rates of HPV DNA and E6/E7 mRNA were significantly higher in patients with cervical intraepithelial neoplasia and cervical cancer compared to those with gynecological inflammation. Additionally, HPV E6/E7 mRNA showed promising value in the detection of high-level intraepithelial neoplasia and cervical cancer.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Virology
Alicia Zhingre, Cesar Bedoya-Pilozo, Diana Gutierrez-Pallo, Ines Badano, Andres Herrera-Yela, Zoila Salazar, Damaris Alarcon, Natali Arguello-Bravo, Maylen Espinoza, Patricio Ponce, Yudira Soto, Andres Carrazco-Montalvo
Summary: This study aimed to analyze the E6 and E7 oncogenes of HPV16 in women with cancerous and precancerous cervical lesions from the Ecuadorian coast. The study found that the E6 350G or L83V and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V variants are associated with an increased risk of cervical cancer. Furthermore, the D (26.1%) and A (73.9%) lineages of HPV16 were found to be circulating, with the frequency of D being higher than previous studies in Ecuador and Latin America.
Article
Immunology
Jesus Dominguez-Riscart, Ana-Belen Ariza-Jimenez, Celia Baez-Castillo, Isabel Mateo-Gavira
Summary: This study aims to analyze the knowledge of main caregivers of trans girls about HPV-related diseases and factors associated with HPV vaccination intention. The results showed that only a minority of caregivers had a high level of HPV knowledge, and a small number of trans girls had been vaccinated, with a low intention of vaccination. Therefore, it is necessary to strengthen education and prevention efforts for HPV-related diseases among trans girls to improve their knowledge and vaccination coverage.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Giovanni Gabutti, Erica d'Anchera, Francesco De Motoli, Marta Savio, Armando Stefanati
Summary: Human papilloma virus (HPV) is mainly transmitted sexually and vaccination has been effective in reducing infections and diseases. The COVID-19 pandemic has impacted vaccination coverage in Italy, which has not yet met the national target set by the Italian National Immunization Plan (NIP).
Review
Public, Environmental & Occupational Health
Hong Feng, Yuan Deng
Summary: This study found that the prevalence of HPV infection in retinoblastoma (RB) samples was 15%, with HPV 16 being the most common genotype. Mexico, India, and Brazil had the highest HPV prevalence in RB samples. Although the association between HPV and RB was not significant, it was observed to be significant after excluding a study with substantial weight.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Serena Varesano, Alessandra Pulliero, Emanuele Martorana, Gabriele Pizzino, Gabriele Raciti, Simona Coco, Valerio Gaetano Vellone, Alberto Izzotti
Summary: Cervical cancer is the second most common cancer among women aged 15 to 44, affecting more than 500,000 women each year. The aim of the proposed study is to implement routine diagnostics of HPV precancerous cervical lesions by introducing new molecular diagnostic tools. MicroRNA analysis panel can improve early diagnosis, understand the nature of the lesion, and improve the clinical management of patients with HPV precancerous cervical lesions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Siaw Shi Boon, Yin Ching Lee, Ka Lai Yip, Ho Yin Luk, Chuanyun Xiao, Man Kin Yim, Zigui Chen, Paul Kay Sheung Chan
Summary: This study identified Aurora kinase B (AurB) as a novel interacting partner of human papillomavirus E6, and investigated the molecular mechanism of how E6 recruits AurB to induce cell immortalization and proliferation, leading to eventual cancer development. The study also evaluated the efficacy of Aurora kinase inhibitors in halting HPV-mediated carcinogenesis. The findings revealed the potential for specific and selective inhibitors to be developed for the treatment of HPV-related cancers.
Review
Virology
Rohit Gupta, Peter L. Rady, Andrew G. Sikora, Stephen K. Tyring
Summary: Sinonasal inverted papillomas (IPs) are rare tumors that typically have a benign nature, but some can progress to malignancy. While there is speculation about the potential role of human papillomaviruses (HPVs) in the development of IPs, the association between HPV and IPs has not been definitively proven. Synthesizing early and recent studies may provide insights into the pathogenesis of IPs and the role of HPV in their development.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Alejandra Garcia, Giovanna Maldonado, Jose L. Gonzalez, Yuri Svitkin, David Cantu, Alejandro Garcia-Carranca, Nahum Sonenberg, Greco Hernandez
Summary: HPV infection is a necessary factor for the development of cervical cancer, and viral oncoproteins E6 and E7 play central roles in the carcinogenic process. Studies have shown that certain HPV subtypes use unique mechanisms for translating E6/E7 in cervical tumors, shedding light on the mechanism of cancer development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Alexander Pedroza-Gonzalez, Julia Reyes-Reali, Maricela Campos-Solorzano, Eloy Moises Blancas-Diaz, Janik Adriana Tomas-Morales, Aldo Aram Hernandez-Aparicio, Daniel Montes De Oca-Samperio, Efrain Garrido, Gina Stella Garcia-Romo, Claudia Fabiola Mendez-Catala, Patricia Alvarez Ortiz, Janet Sanchez Ramos, Maria Isabel Mendoza-Ramos, Alberto Daniel Saucedo-Campos, Glustein Pozo-Molina
Summary: HPV is a common sexually transmitted disease and a major cause of cervical cancer. This study found a higher prevalence of HPV infection in university women, which was associated with early sexual debut, an increasing number of sexual partners, and a low proportion of HPV seropositivity.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Matthew Uzelac, Armon Barakchi, Varsha Beldona, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. M. Ongkeko
Summary: This study examines genomic mutations in HPV-infected HNSCC patients and finds that high expression of E6 and E7 oncoproteins is associated with an increase in point mutations and specific chromosomal alterations.
Article
Health Policy & Services
Dorothy Xuanxian Kenny, Katherine Hsueh, Ryan William Walters, John Joseph Cote
Summary: Refugee populations, particularly Burmese refugee women, face higher risks due to disparities in HPV vaccine and Pap smear screening rates. Improvement is needed in HPV vaccination and Pap smear rates among refugee populations.
JOURNAL OF COMMUNITY HEALTH
(2021)
Review
Immunology
Marco Torella, Maria Maddalena Marrapodi, Carlo Ronsini, Alessandro Ferdinando Ruffolo, Andrea Braga, Matteo Frigerio, Emanuele Amabile, Maria Giovanna Vastarella, Francesca Rossi, Gaetano Riemma
Summary: This meta-analysis suggests that the quadrivalent human papilloma virus (HPV) vaccine (4vHPV) is not associated with an increased risk of premature ovarian insufficiency (POI). There is no significant difference in POI risk between individuals vaccinated with 4vHPV and those who are unvaccinated or vaccinated with other childhood vaccines. Additionally, there is no difference in POI risk between 4vHPV and 2vHPV or 9vHPV vaccines.
Article
Multidisciplinary Sciences
Mario Songane, Volker Grossmann
Summary: HPV vaccines play a crucial role in preventing cervical cancer, but high prices due to patent protection hinder widespread access, especially in low- and middle-income countries. Patent buy-outs could potentially lower vaccine prices, increase vaccination rates, and maintain incentives for innovation.
Article
Pathology
Alexandra L. Isaacson, Ramakrishna R. Sompallae, Natalya Guseva, Andrew M. Bellizzi, Aaron D. Bossler, Deqin Ma
Summary: This study aimed to identify therapeutic targets and correlate with clinical outcomes in metastatic UM through mutation profiling using NGS. The results showed that GNAQ/11-SF3B1 mutations were associated with a longer time to first metastasis compared to GNAQ/11-BAP1 mutations. Coexisting BAP1/SF3B1 and GNAQ/11 mutations were unique to UM, and SF3B1 mutations may play a role in UM metastasis.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Virology
Francoise A. Gourronc, Michael R. Rebagliati, Breanna Kramer-Riesberg, Anthony M. Fleck, J. J. Patten, Kathleen Geohegan-Barek, Kelly N. Messingham, Robert A. Davey, Wendy Maury, Aloysius J. Klingelhutz
Summary: Adipocytes in adipose tissue may contribute to the inflammatory response and coagulopathy during EBOV pathogenesis.
Article
Immunology
Paola de Haas, Marien I. de Jonge, Hans J. P. M. Koenen, Ben Joosten, Mirian C. H. Janssen, Lonneke de Boer, Wiljan J. A. J. Hendriks, Dirk J. Lefeber, Alessandra Cambi
Summary: Congenital disorders of glycosylation (CDG) are a group of genetic metabolic diseases characterized by abnormal synthesis, attachment, or processing of protein glycosylation. Recent studies have shown immunological dysfunctions in some types of CDG. However, there is still limited research on immune cell dysfunction in PMM2-CDG and other CDG types. Immune cell models that mimic PMM2-CDG could overcome the challenges of studying patient immune cells, such as limited availability of patient material. Initial observations show abnormal surface glycosylation patterns and slightly increased uptake of fungal particles in PMM2-CDG monocytes. The use of PMM2 knockdown THP-1 monocytes as a model may be superior to tunicamycin-treated THP-1 cells for studying immune dysfunction in CDG.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Kevin Cheung, Aaron D. Bossler, Sarah L. Mott, Megan Zeisler, Julie McKillip, Yousef Zakharia, Brian L. Swick, Jennifer G. Powers
Summary: This study investigated the genetic signature of early-stage melanomas in Veterans through hotspot mutation profiling. The results revealed high prevalence of BRAF, TP53, and NRAS mutations, with TP53 being a potential marker for recurrent melanoma and military population.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Furqan, Taher Abu-Hejleh, Laura M. Stephens, Stacey M. Hartwig, Sarah L. Mott, Casey F. Pulliam, Michael Petronek, John B. Henrich, Melissa A. Fath, Jon C. Houtman, Steven M. Varga, Kellie L. Bodeker, Aaron D. Bossler, Andrew M. Bellizzi, Jun Zhang, Varun Monga, Hariharasudan Mani, Marina Ivanovic, Brian J. Smith, Margaret M. Byrne, William Zeitler, Brett A. Wagner, Garry R. Buettner, Joseph J. Cullen, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Summary: The combination of pharmacological ascorbate and chemotherapy improves tumor response in advanced stage non-small cell lung cancer (NSCLC) patients and appears to alter the host immune response. Further investigation is needed to explore the potential of this treatment as an adjuvant to immunotherapy.
Article
Immunology
Elisabeth G. Vichaya, Josephine K. Darpolor, Phillip S. Gross, Jessica M. Molkentine, Daniel W. Vermeer, Paola D. Vermeer, John H. Lee, Cullen M. Taniguchi, Robert Dantzer
Summary: A study was conducted using a murine model of cancer survivorship to investigate the role of associative learning in the persistence of fatigue. The results showed that re-exposure to a treatment-related olfactory cue could acutely reinstate fatigue. This is the first demonstration that associative processes can modulate the persistence of cancer-related fatigue-like behavior.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell Biology
Wiljan J. A. J. Hendriks, Remco T. P. van Cruchten, Rafael Pulido
Summary: Protein tyrosine phosphatases and protein tyrosine kinases play important roles in controlling molecular signaling processes at cellular and organismal levels, affecting the quality of life. This review focuses on studying germline variants in the genes encoding the thirty-seven classical members of the protein tyrosine phosphatase superfamily. The results suggest a potential association between individual genes and specific disorders, highlighting the need for further research to establish a comprehensive genotype-phenotype map for this intriguing protein family.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Francoise A. Gourronc, Brynn K. Helm, Larry W. Robertson, Michael S. Chimenti, Hans-Joachim Lehmler, James A. Ankrum, Aloysius J. Klingelhutz
Summary: This study investigated the effects of PCB126 on gene transcription in human preadipocytes using RNAseq. The results showed that exposure to PCB126 caused changes in gene expression, which may be associated with the development of metabolic syndrome. These findings provide important insights into the impact of PCB126 and other dioxin-like compounds on health.
Article
Dermatology
Hanna Niehues, Gijs Rikken, Ferry F. J. Kersten, Jorine M. Eeftens, Ivonne M. J. J. Van Vlijmen-Willems, Diana Rodijk-Olthuis, Patrick A. M. Jansen, Wiljan J. A. J. Hendriks, Thomas H. A. Ederveen, Joost Schalkwijk, Ellen H. Van den Bogaard, Patrick L. J. M. Zeeuwen
Summary: Late cornified envelope (LCE) proteins are small cationic epidermal proteins with antimicrobial properties. We identified CYSRT1 as an interacting partner of LCE proteins, which is specifically expressed in cutaneous and oral epithelia and colocalizes with LCE proteins in the upper layers of the suprabasal epidermis. CYSRT1 has antimicrobial activity against Pseudomonas aeruginosa and contributes to the constitutive epidermal antimicrobial host defense repertoire.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Jos P. H. Smits, Noa J. M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A. M. Jansen, Ivonne M. J. J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Celine Evrard, Yves Poumay, Michel van Geel, Wiljan J. A. J. Hendriks, Joost Schalkwijk, Patrick L. J. M. Zeeuwen, Ellen H. van den Bogaard
Summary: This study demonstrates the phenotypical and functional consequences of FLG deficiency, showing its crucial role in epidermal barrier function and differentiation. The results provide insights into the exact role of FLG in skin biology and disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Pathology
M. Anwar Iqbal, Ulrich Broeckel, Brynn Levy, Steven Skinner, Nikhil S. Sahajpal, Vanessa Rodriguez, Aaron Stence, Kamel Awayda, Gunter Scharer, Cindy Skinner, Roger Stevenson, Aaron Bossler, Peter L. Nagy, Ravindra Kolhe
Summary: This study compared optical genome mapping (OGM) with current standard-of-care (SOC) methods in clinical cytogenetics. OGM showed high concordance with SOC for technical and clinical classification, as well as reproducibility. The authors recommend OGM as an alternative to SOC for rapid detection and diagnosis in postnatal constitutional disorders.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Article
Multidisciplinary Sciences
Anthony C. Restaino, Austin Walz, Samuel J. Vermeer, Jeffrey Barr, Attila Kovacs, Robin R. Fettig, Daniel W. Vermeer, Hunter Reavis, Caitlin S. Williamson, Christopher T. Lucido, Tuany Eichwald, Dalia K. Omran, Euihye Jung, Lauren E. Schwartz, Maria Bell, DesiRae M. Muirhead, Jody E. Hooper, William C. Spanos, Ronny Drapkin, Sebastien Talbot, Paola D. Vermeer
Summary: The functional role of intratumoral nerves in disease is not well understood. Our study demonstrates that these nerves form functional connections within tumors, with significantly higher electrical activity observed in malignancies compared to benign disease or normal tissues. We also show that pharmacologic silencing of tumoral electrical activity is possible, and animals lacking nociceptor neurons exhibit reduced electrical activity in implanted tumors. Furthermore, the presence of the neuropeptide Substance P and its receptor NK1R within tumors promote cellular proliferation and migration. This study reveals a mechanism by which intratumoral nerves contribute to cancer progression.
Article
Multidisciplinary Sciences
Mariam Y. El-Hattab, Noah Sinclair, Jesse N. Liszewski, Michael V. Schrodt, Jacob Herrmann, Aloysius J. Klingelhutz, Edward A. Sander, James A. Ankrum
Summary: Adipocytes regulate tissues through the production of adipokines that act locally and systemically. They also play a critical role in regulating the healing process. In this study, a three-dimensional human adipocyte spheroid system was developed to understand how mature adipocytes signal to dermal fibroblasts to induce myofibroblast conversion. It was found that a factor secreted by mature adipocytes, identified as adiponectin, induces fibroblast to myofibroblast conversion through a pathway independent of TGF-beta 1.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Meeting Abstract
Dermatology
H. Niehues, G. Rikken, F. Kersten, J. Eeftens, M. Oortveld, D. van der Krieken, P. Jansen, I. M. van Vlijmen-Willems, J. P. Smits, N. van den Brink, W. Hendriks, T. Ederveen, J. Schalkwijk, P. L. Zeeuwen, E. H. Van den Bogaard
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anthony C. Restaino, Paola D. Vermeer
Summary: The identification of nerves in the tumor microenvironment has opened up a new area of research in cancer biology. Studies show that various types of peripheral nerves are present in the tumor microenvironment, and an increased nerve density correlates with poorer prognosis. Nerve-mediated alterations impact disease through processes like direct communication with cancer cells, modifying immune populations, and changing stromal components.
