Epigenetic factors in cancer development: Polycomb group proteins

Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML

(2010) T. A. Paul et al.   BLOOD

A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness

(2010) Caroline J. Woo et al.   CELL

Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation

(2010) Emily Walker et al.   Cell Stem Cell

Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2

(2010) Klaus Hansen et al.   Epigenetics

Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer

(2010) Eva Karamitopoulou et al.   EUROPEAN JOURNAL OF CANCER

Jarid2 and PRC2, partners in regulating gene expression

(2010) G. Li et al.   GENES & DEVELOPMENT

Expression of polycomb protein EZH2 in multi-stage tissues of gastric carcinogenesis

(2010) Gan Hui CAI et al.   Journal of Digestive Diseases

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

(2010) David Landeira et al.   NATURE CELL BIOLOGY

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bβ and TSLC1 in neuroblastoma

(2010) H Ochiai et al.   ONCOGENE

Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras

(2010) N. P. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Polycomb group protein-mediated repression of transcription

(2010) Lluís Morey et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia

(2009) Xin Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Bmi1 deficient neural stem cells have increased Integrin dependent adhesion to self-secreted matrix

(2009) Sophia W.M. Bruggeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Monoallelic gene expression and mammalian evolution

(2009) Barry Keverne   BIOESSAYS

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

(2009) W. Fiskus et al.   BLOOD

Polycomb CBX7 Promotes Initiation of Heritable Repression of Genes Frequently Silenced with Cancer-Specific DNA Hypermethylation

(2009) H. P. Mohammad et al.   CANCER RESEARCH

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

(2009) J. M. Friedman et al.   CANCER RESEARCH

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells

(2009) M. Hussain et al.   CANCER RESEARCH

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

(2009) Elena Ezhkova et al.   CELL

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

(2009) Jamy C. Peng et al.   CELL

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

(2009) Xiaohua Shen et al.   CELL

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

(2009) Angela Sing et al.   CELL

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

(2009) H. Boukarabila et al.   GENES & DEVELOPMENT

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

The novel tumor-suppressor Mel-18 in prostate cancer: Its functional polymorphism, expression and clinical significance

(2009) Wei Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

(2009) Li-Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Bmi-1 is critical for the proliferation and invasiveness of gastric carcinoma cells

(2009) Wei Li et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal

(2009) M. Abdouh et al.   JOURNAL OF NEUROSCIENCE

Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell Line

(2009) B. D.W. Karanikolas et al.   MOLECULAR CANCER RESEARCH

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells

(2009) F. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Inflaming metastasis

(2009) Alberto Mantovani   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

In Brief

(2009)   NATURE REVIEWS NEUROSCIENCE

BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases

(2009) M J Hoenerhoff et al.   ONCOGENE

GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma

(2009) Serdar Korur et al.   PLoS One

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Copy number alterations of the polycomb gene BMI1 in gliomas

(2008) Valtteri Häyry et al.   ACTA NEUROPATHOLOGICA

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

BMI-1 Promotes Ewing Sarcoma Tumorigenicity Independent of CDKN2A Repression

(2008) D. Douglas et al.   CANCER RESEARCH

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

Mel-18 Negatively Regulates INK4a/ARF-Independent Cell Cycle Progression via Akt Inactivation in Breast Cancer

(2008) J.-Y. Lee et al.   CANCER RESEARCH

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

Polycomb complexes and epigenetic states

(2008) Yuri B Schwartz et al.   CURRENT OPINION IN CELL BIOLOGY

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

(2008) D. Pasini et al.   GENES & DEVELOPMENT

The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma

(2008) Motoko Sasaki et al.   LABORATORY INVESTIGATION

Loss of BMI-1 expression is associated with clinical progress of malignant melanoma

(2008) Ingeborg M Bachmann et al.   MODERN PATHOLOGY

Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo

(2008) K. Sarma et al.   MOLECULAR AND CELLULAR BIOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Cyclical DNA methylation of a transcriptionally active promoter

(2008) Raphaël Métivier et al.   NATURE

Transient cyclical methylation of promoter DNA

(2008) Sara Kangaspeska et al.   NATURE

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

(2008) Yutaka Kondo et al.   NATURE GENETICS

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas

(2008) Kazunori Kidani et al.   ORAL ONCOLOGY

Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion

(2008) J. S. Dovey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells

(2008) H. Li et al.   SCIENCE

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE

Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

(2008) J. Zhao et al.   SCIENCE