Translation factors and ribosomal proteins control tumor onset and progression: how?

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

(2013) Jordan Gallinetti et al.   BIOCHEMICAL JOURNAL

Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs

(2013) Xiangyue Wu et al.   NUCLEIC ACIDS RESEARCH

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Incidence of neoplasia in Diamond Blackfan anemia: a report from the Diamond Blackfan Anemia Registry

(2012) A. Vlachos et al.   BLOOD

L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

(2012) E. M. Payne et al.   BLOOD

Ribosome Biogenesis and Control of Cell Proliferation: p53 Is Not Alone

(2012) G. Donati et al.   CANCER RESEARCH

eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

(2012) T. Alain et al.   CANCER RESEARCH

RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency

(2012) Viviana Volta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Akt-associated microRNAs

(2012) Min Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical Applications for microRNAs in Cancer

(2012) S P Nana-Sinkam et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting mTOR Pathways in Human Malignancies

(2012) Angelica Fasolo et al.   CURRENT PHARMACEUTICAL DESIGN

RNA Binding Protein/RNA Element Interactions and the Control of Translation

(2012) Xavier Pichon et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

(2012) Marilena V. Iorio et al.   EMBO Molecular Medicine

RACK1 research - ships passing in the night?

(2012) Toby J. Gibson   FEBS LETTERS

A new framework for understanding IRES-mediated translation

(2012) Anton A. Komar et al.   GENE

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

(2012) S. Fumagalli et al.   GENES & DEVELOPMENT

Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma

(2012) Yuanyuan Ruan et al.   JOURNAL OF CLINICAL INVESTIGATION

Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome

(2012) Gyanesh Sharma et al.   JOURNAL OF STRUCTURAL BIOLOGY

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

Erratum: Regulation of cytoplasmic mRNA decay

(2012) Daniel R. Schoenberg et al.   NATURE REVIEWS GENETICS

NMD: a multifaceted response to premature translational termination

(2012) Stephanie Kervestin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Erratum: miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long non-coding RNAs and cancer: a new frontier of translational research?

(2012) R Spizzo et al.   ONCOGENE

The Tumor Suppressive Role of eIF3f and Its Function in Translation Inhibition and rRNA Degradation

(2012) Fushi Wen et al.   PLoS One

RACK1 Is a Ribosome Scaffold Protein for β-actin mRNA/ZBP1 Complex

(2012) Marcello Ceci et al.   PLoS One

Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation

(2012) L. Blau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs

(2012) M. Badura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hallmarks of cancer

(2012) Tony Gutschner et al.   RNA Biology

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

(2012) Stéphanie Dabo et al.   Viruses-Basel

Single-Molecule Analysis of Translational Dynamics

(2012) A. Petrov et al.   Cold Spring Harbor Perspectives in Biology

Translational Control in Cancer Etiology

(2012) D. Ruggero   Cold Spring Harbor Perspectives in Biology

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

A Forward Genetic Screen Identifies Eukaryotic Translation Initiation Factor 3, Subunit H (eIF3h), as an Enhancer of Variegation in the Mouse

(2012) Lucia Daxinger et al.   G3-Genes Genomes Genetics

Sixth International Congress on Shwachman-Diamond syndrome: from patients to genes and back

(2011) Johnson M. Liu et al.   Annals of the New York Academy of Sciences

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts

(2011) R. Horos et al.   BLOOD

Defective ribosome assembly in Shwachman-Diamond syndrome

(2011) C. C. Wong et al.   BLOOD

Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia

(2011) Hidetsugu Torihara et al.   BRITISH JOURNAL OF HAEMATOLOGY

Impairment of Cytoplasmic eIF6 Activity Restricts Lymphomagenesis and Tumor Progression without Affecting Normal Growth

(2011) Annarita Miluzio et al.   CANCER CELL

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning

(2011) Nadya Kondrashov et al.   CELL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Inflammatory breast cancer cells are constitutively adapted to hypoxia

(2011) Deborah Silvera et al.   CELL CYCLE

Translational control by 80S formation and 60S availability: The central role of eIF6, a rate limiting factor in cell cycle progression and tumorigenesis

(2011) Daniela Brina et al.   CELL CYCLE

Cellular IRES-mediated translation

(2011) Anton A Komar et al.   CELL CYCLE

Emerging Therapies Targeting Tumor Vasculature in Multiple Myeloma and other Hematologic and Solid Malignancies

(2011) K. Podar et al.   CURRENT CANCER DRUG TARGETS

The cancerous translation apparatus

(2011) Craig R Stumpf et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

(2011) Guillaume Jannot et al.   EMBO REPORTS

TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression

(2011) Martin Jädersten et al.   JOURNAL OF CLINICAL ONCOLOGY

Requirement of rRNA Methylation for 80S Ribosome Assembly on a Cohort of Cellular Internal Ribosome Entry Sites

(2011) A. Basu et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of Eukaryotic Translation Initiation Factor 4G1 (eIF4G1) by Protein Kinase C  Regulates eIF4G1 Binding to Mnk1

(2011) M. Dobrikov et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Nonsense-Mediated RNA Decay by the Tumor Microenvironment Promotes Tumorigenesis

(2011) D. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The biological and therapeutic relevance of mRNA translation in cancer

(2011) Sarah P. Blagden et al.   Nature Reviews Clinical Oncology

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

mRNA helicases: the tacticians of translational control

(2011) Armen Parsyan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma

(2011) Motoyuki Otsuka et al.   PLoS One

Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1

(2011) Stefano Grosso et al.   PLoS One

The Structure of the Eukaryotic Ribosome at 3.0 A Resolution

(2011) A. Ben-Shem et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Post-transcriptional and post-translational regulation of Bcl2: Figure 1

(2010) Shaun Willimott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Ribosomal dysfunction and inherited marrow failure

(2010) Karthik A. Ganapathi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA Translation

(2010) Lorenzo Montanaro et al.   CANCER RESEARCH

Loss of Function of the Tumor Suppressor DKC1 Perturbs p27 Translation Control and Contributes to Pituitary Tumorigenesis

(2010) C. Bellodi et al.   CANCER RESEARCH

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

(2010) Won Jun Oh et al.   EMBO JOURNAL

Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

(2010) Cristian Bellodi et al.   EMBO JOURNAL

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

(2010) Federica Di Nicolantonio et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of 4E-BP1 Function as a Critical Determinant of Enzastaurin-Induced Apoptosis

(2010) C. A. Dumstorf et al.   MOLECULAR CANCER THERAPEUTICS

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

(2010) V Iadevaia et al.   ONCOGENE

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1

(2010) L C Cobbold et al.   ONCOGENE

Silencing of Ribosomal Protein S9 Elicits a Multitude of Cellular Responses Inhibiting the Growth of Cancer Cells Subsequent to p53 Activation

(2010) Mikael S. Lindström et al.   PLoS One

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

Diamond-Blackfan anemia, ribosome and erythropoiesis

(2010) L. Da Costa et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Structural and functional diversity of viral IRESes

(2009) Laurent Balvay et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Driving ribosome assembly

(2009) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer in dyskeratosis congenita

(2009) B. P. Alter et al.   BLOOD

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

Inhibition of eIF2α Dephosphorylation Maximizes Bortezomib Efficiency and Eliminates Quiescent Multiple Myeloma Cells Surviving Proteasome Inhibitor Therapy

(2009) Denis M. Schewe et al.   CANCER RESEARCH

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs

(2009) D. M. Landry et al.   GENES & DEVELOPMENT

Shwachman-Diamond Syndrome: A Review of the Clinical Presentation, Molecular Pathogenesis, Diagnosis, and Treatment

(2009) Lauri Burroughs et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The rise of a ribosomopathy and increased cancer risk

(2009) Friedrich Luft   JOURNAL OF MOLECULAR MEDICINE-JMM

Clinical and laboratory characterization of a large cohort of patients with Castleman disease retrospectively collected from a single center

(2009) Yujun Dong et al.   LEUKEMIA & LYMPHOMA

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors

(2009) Hannes C. A. Drexler   PLoS One

Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells

(2009) Stéphane Belin et al.   PLoS One

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients

(2008) Hanna T. Gazda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Extended follow-up of the Finnish cartilage-hair hypoplasia cohort confirms high incidence of non-Hodgkin lymphoma and basal cell carcinoma

(2008) Mervi Taskinen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Nucleolus, Ribosomes, and Cancer

(2008) Lorenzo Montanaro et al.   AMERICAN JOURNAL OF PATHOLOGY

PKCβII modulates translation independently from mTOR and through RACK1

(2008) Stefano Grosso et al.   BIOCHEMICAL JOURNAL

Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family

(2008) N. Danilova et al.   BLOOD

Reduced Eukaryotic Initiation Factor 2Bε-Subunit Expression Suppresses the Transformed Phenotype of Cells Overexpressing the Protein

(2008) James W. Gallagher et al.   CANCER RESEARCH

A new database for ribosomal protein genes which are mutated in Diamond-Blackfan Anemia

(2008) Ilenia Boria et al.   HUMAN MUTATION

An Oncogenic Role for the Phosphorylated h-Subunit of Human Translation Initiation Factor eIF3

(2008) Lili Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

(2008) Valentina Gandin et al.   NATURE

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

(2008) Kelly A McGowan et al.   NATURE GENETICS

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

(2008) A. W. MacInnes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of human ribosomal proteins in the maturation of rRNA and ribosome production

(2008) S. Robledo et al.   RNA

Re-programming of translation following cell stress allows IRES-mediated translation to predominate

(2007) Keith A. Spriggs et al.   BIOLOGY OF THE CELL