The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)

Opposite roles of myocardin and atrogin-1 in L6 myoblast differentiation

(2013) Yulan Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Memories from the Polycomb Group Proteins

(2012) Chiara Lanzuolo et al.   Annual Review of Genetics

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

(2012) Sergio Valente et al.   BIOCHIMIE

The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation

(2012) Irene Marchesi et al.   CELL CYCLE

Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation

(2012) O. M. Gannon et al.   CLINICAL CANCER RESEARCH

TP53 Genomic Status Regulates Sensitivity of Gastric Cancer Cells to the Histone Methylation Inhibitor 3-Deazaneplanocin A (DZNep)

(2012) L. L. Cheng et al.   CLINICAL CANCER RESEARCH

Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells

(2012) W. Fiskus et al.   CLINICAL CANCER RESEARCH

FGFR4 Blockade Exerts Distinct Antitumorigenic Effects in Human Embryonal versus Alveolar Rhabdomyosarcoma

(2012) L. E. S. Crose et al.   CLINICAL CANCER RESEARCH

Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets

(2012) E. R. Lawlor et al.   CLINICAL CANCER RESEARCH

A transcriptional repressor co-regulatory network governing androgen response in prostate cancers

(2012) Kern Rei Chng et al.   EMBO JOURNAL

Ezh2 maintains a key phase of muscle satellite cell expansion but does not regulate terminal differentiation

(2012) S. Woodhouse et al.   JOURNAL OF CELL SCIENCE

Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells

(2012) Yannick D. Benoit et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PAX3/FOXO1Fusion Gene Status Is the Key Prognostic Molecular Marker in Rhabdomyosarcoma and Significantly Improves Current Risk Stratification

(2012) Edoardo Missiaglia et al.   JOURNAL OF CLINICAL ONCOLOGY

Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation

(2012) Richard L. Momparler et al.   LEUKEMIA RESEARCH

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

(2012) L. J. Valentijn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Methyltransferase KMT1A Restrains Entry of Alveolar Rhabdomyosarcoma Cells into a Myogenic Differentiated State

(2011) M.-H. Lee et al.   CANCER RESEARCH

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

(2011) S. Ramirez-Peinado et al.   CANCER RESEARCH

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR

(2011) C. Wang et al.   CANCER RESEARCH

Deregulated expression of miR-26a and Ezh2 in Rhabdomyosarcoma

(2011) Roberta Ciarapica et al.   CELL CYCLE

Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage

(2011) Z Wu et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo

(2011) L Raimondi et al.   CELL DEATH AND DIFFERENTIATION

Polycomb Repressor Complex-2 Is a Novel Target for Mesothelioma Therapy

(2011) C. D. Kemp et al.   CLINICAL CANCER RESEARCH

Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells

(2011) A. H. Juan et al.   GENES & DEVELOPMENT

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression

(2011) T. Fan et al.   MOLECULAR CANCER RESEARCH

Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation

(2011) Kambiz Mousavi et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Caspase-3, myogenic transcription factors and cell cycle inhibitors are regulated by leukemia inhibitory factor to mediate inhibition of myogenic differentiation

(2011) Liam C Hunt et al.   Skeletal Muscle

Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer

(2010) L. Cao et al.   CANCER RESEARCH

EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-β1 and is a predictor of outcome in ovarian carcinoma patients

(2010) Zhi-Yue Rao et al.   CARCINOGENESIS

Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

(2010) Viviana Moresi et al.   CELL

TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration

(2010) Daniela Palacios et al.   Cell Stem Cell

Gene Expression Profiling for Survival Prediction in Pediatric Rhabdomyosarcomas: A Report From the Children's Oncology Group

(2010) Elai Davicioni et al.   JOURNAL OF CLINICAL ONCOLOGY

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

(2010) Daniel Williamson et al.   JOURNAL OF CLINICAL ONCOLOGY

Polycomb Target Genes Are Silenced in Multiple Myeloma

(2010) Antonia Kalushkova et al.   PLoS One

Molecular Classification of Rhabdomyosarcoma—Genotypic and Phenotypic Determinants of Diagnosis

(2009) Elai Davicioni et al.   AMERICAN JOURNAL OF PATHOLOGY

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

(2009) W. Fiskus et al.   BLOOD

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

(2009) Jamy C. Peng et al.   CELL

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

(2009) Xiaohua Shen et al.   CELL

Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression

(2009) Z L Wu et al.   CELL DEATH AND DIFFERENTIATION

Atrogin-1/MAFbx Enhances Simulated Ischemia/Reperfusion-induced Apoptosis in Cardiomyocytes through Degradation of MAPK Phosphatase-1 and Sustained JNK Activation

(2009) Ping Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential cell death regulation between adult-unloaded and aged rat soleus muscle

(2009) Tomonori Ogata et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Mir-214-Dependent Regulation of the Polycomb Protein Ezh2 in Skeletal Muscle and Embryonic Stem Cells

(2009) Aster H. Juan et al.   MOLECULAR CELL

Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo

(2009) Julie Lagirand-Cantaloube et al.   PLoS One

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

(2008) Huating Wang et al.   CANCER CELL

Mouse Mesenchymal Stem Cells Expressing PAX-FKHR Form Alveolar Rhabdomyosarcomas by Cooperating with Secondary Mutations

(2008) Y.-X. Ren et al.   CANCER RESEARCH

MicroRNA-26a Targets the Histone MethyltransferaseEnhancer of Zeste homolog 2during Myogenesis

(2008) Chung Fai Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased muscle atrophy F-box (MAFbx) expression in regenerating muscle after muscle-damaging exercise

(2008) Atsushi Okada et al.   MUSCLE & NERVE

Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma

(2007) Ken Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS