Article
Oncology
Sumit Gupta, David T. Teachey, Zhiguo Chen, Karen R. Rabin, Kimberly P. Dunsmore, Eric C. Larsen, Kelly W. Maloney, Leonard A. Mattano, Stuart S. Winter, Andrew J. Carroll, Nyla A. Heerema, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Elizabeth A. Raetz, Naomi J. Winick, Mignon L. Loh, Stephen P. Hunger, Meenakshi Devidas
Summary: Boys with acute lymphoblastic leukemia continue to have lower survival rates compared to girls. This study found that the sex-based disparities still exist in contemporary therapy, with boys experiencing inferior event-free survival and overall survival, primarily due to higher rates of relapse, particularly involving the central nervous system.
Article
Oncology
Zsuzsanna Gaal, Zsuzsanna Jakab, Bettina Karai, Aniko Ujfalusi, Miklos Petras, Krisztian Kallay, Agnes Kelemen, Reka Simon, Gergely Krivan, Gabor T. Kovacs, Csongor Kiss, Istvan Szegedi
Summary: Outcome measures of pediatric acute myeloid leukemia (AML) in Hungary have significantly improved in recent years, with advancements in event-free and overall survival attributed to the application of modern diagnostic and therapeutic guidelines, advanced support systems, and increased efficacy of hematopoietic stem cell transplantation. Significant progress has been observed in the treatment of acute promyelocytic leukemia.
Article
Oncology
Bailey A. Martin-Giacalone, Melissa A. Richard, Michael E. Scheurer, Javed Khan, Pagna Sok, Priya B. Shetty, Stephen J. Chanock, Shengchao Alfred Li, Meredith Yeager, Deborah A. Marquez-Do, Donald A. Barkauskas, David Hall, Matthew T. McEvoy, Austin L. Brown, Aniko Sabo, Paul Scheet, Chad D. Huff, Stephen X. Skapek, Douglas S. Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Philip J. Lupo
Summary: A genome-wide association study identified genetic variants associated with event-free survival (EFS) and overall survival (OS) in individuals with rhabdomyosarcoma (RMS). Two SNPs, rs17321084 and rs10094840, were found to be associated with worse EFS and OS respectively. Additionally, rs17321084 was found to lie in a binding region for GATA2 and GATA3, while rs10094840 was associated with SPAG1 and RNF19A expression. CTNNA3 rs2135732 and MED31 rs74504320 were also identified to be associated with worse OS among individuals with alveolar RMS.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Jonathan Metts, Wei Xue, Zhengya Gao, Ralph Ermoian, Julie A. A. Bradley, Michael A. A. Arnold, Roshni Dasgupta, Rajkumar Venkatramani, David Walterhouse
Summary: This study reported the long-term follow-up results of patients with orbital rhabdomyosarcoma (ORMS) treated on COG trials from 1997 to 2013. The study found that both low-risk and non-low-risk ORMS patients had favorable long-term survival outcomes. Additionally, a significant proportion of patients with recurrent ORMS may achieve long-term survival.
Article
Oncology
Natasha N. Frederick, Kristin Bingen, Sharon L. Bober, Brooke Cherven, Xinxin Xu, Gwendolyn P. Quinn, Lingyun Ji, David R. Freyer
Summary: Many pediatric oncology clinicians play minimal roles in sexual health care for adolescents and young adults, and most sexual health topics are rarely discussed. Provider-directed education and training interventions have the potential to improve sexual health care for AYA cancer patients.
Article
Oncology
Timothy B. Lautz, Yueh-Yun Chi, Minjie Li, Suzanne L. Wolden, Dana L. Casey, Jonathan C. Routh, Candace F. Granberg, Odion Binite, Erin R. Rudzinski, Douglas S. Hawkins, Rajkumar Venkatramani, David A. Rodeberg
Summary: This study compared outcomes in children with group III RMS who did and did not undergo DPE and assessed surgical morbidity. The study found that patients who underwent DPE could receive a decreased radiation dose for definitive local control, leading to improved overall survival in the DPE group.
Article
Hematology
Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Chenyue W. Hu, Rhonda E. Ries, Andrew Ligeralde, Gaye N. Jenkins, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Amina A. Qutub, Eveline S. J. M. de Bont, Terzah M. Horton, Steven M. Kornblau
Summary: This study investigated the proteomic landscape of pediatric acute myeloid leukemia (AML) and identified nine protein expression signatures associated with cytogenetics, mutational state, and prognosis. The study also found certain proteins that were significantly differentially expressed from normal, potentially forming a platform for personalized medicine.
Article
Hematology
Aman Wadhwa, Yanjun Chen, Lindsey Hageman, Anna Hoppmann, Anne Angiolillo, David S. Dickens, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey, Amanda Termuhlen, F. Lennie Wong, Wendy Landier, Smita Bhatia
Summary: The association between individual-level poverty and relapse in children receiving maintenance treatment for acute lymphoblastic leukemia (ALL) was investigated in this study. The analysis showed that living in extreme poverty was associated with a higher risk of relapse among patients. Although nonadherence to medication partially explained the association, further research is needed to understand the underlying mechanisms.
Article
Oncology
Natasha N. Frederick, James L. Klosky, Lillian R. Meacham, Gwendolyn P. Quinn, Joanne Frankel Kelvin, Brooke Cherven, David R. Freyer, Christopher C. Dvorak, Julienne Brackett, Sameeya Ahmed-Winston, Elyse Bryson, Eric J. Chow, Jennifer Levine
Summary: This study examined the infrastructure of fertility preservation services for children and adolescents with cancer, and found that the existing infrastructure is inadequate to provide comprehensive services to patients.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Timothy B. B. Lautz, Wei Xue, Leo Y. Y. Luo, Douglas Fair, Amira Qumseya, Zhengya Gao, Roshni Dasgupta, Dave Rodeberg, Rajkumar Venkatramani
Summary: This study assessed the clinical outcomes of children with chest wall RMS and found that local control is a significant factor affecting survival rates. Complete surgical excision improves outcomes but potential surgical morbidity must also be considered.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Carlos Rodriguez-Galindo, Mark D. Krailo, Emilia M. Pinto, Farzana Pashankar, Christopher B. Weldon, Li Huang, Eliana M. Caran, John Hicks, M. Beth McCarville, David Malkin, Jonathan D. Wasserman, Antonio G. de Oliveira Filho, Michael P. LaQuaglia, Deborah A. Ward, Gerard Zambetti, Maria J. Mastellaro, Alberto S. Pappo, Raul C. Ribeiro
Summary: This study showed that surgery is effective for stage I ACC patients, while a combination of surgery and chemotherapy is beneficial for stage III patients. New treatments should be explored for high-risk stage IV patients due to their poor outcome with current standard treatments.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Aaron R. Weiss, Yen-Lin Chen, Thomas J. Scharschmidt, Wei Xue, Zhengya Gao, Jennifer O. Black, Edwin Choy, Jessica L. Davis, Julie C. Fanburg-Smith, Simon C. Kao, Mark L. Kayton, Sandy Kessel, Ruth Lim, Lynn Million, Scott H. Okuno, Andrew Ostrenga, Marguerite T. Parisi, Daniel A. Pryma, R. Lor Randall, Mark A. Rosen, Barry L. Shulkin, Stephanie Terezakis, Rajkumar Venkatramani, Eduardo Zambrano, Dian Wang, Douglas S. Hawkins, Sheri L. Spunt
Summary: Clinical Trial Updates provide an opportunity to disseminate additional results when key planned co-primary or secondary analyses are not yet available.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Adrian Mosquera Orgueira, Andres Peleteiro Raindo, Miguel Cid Lopez, Jose angel Diaz Arias, Marta Sonia Gonzalez Perez, Beatriz Antelo Rodriguez, Natalia Alonso Vence, Laura Bao Perez, Roi Ferreiro Ferro, Manuel Albors Ferreiro, Aitor Abuin Blanco, Emilia Fontanes Trabazo, Claudio Cerchione, Giovanni Martinnelli, Pau Montesinos Fernandez, Manuel Mateo Perez Encinas, Jose Luis Bello Lopez
Summary: In this study, a new machine learning model ST-123 for predicting AML survival was created using gene expression data. Age, KDM5B, and LAPTM4B were identified as key variables in the model, with high accuracy in predicting survival in high-risk patients and significant prognostic improvements in patients with high-risk mutations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
K. E. Effinger, R. Haardorfer, J. Gilleland Marchak, C. Escoffery, W. Landier, A. Kommajosula, E. Hendershot, K. T. Sadak, D. Eshelman-Kent, K. Kinahan, D. R. Freyer, E. J. Chow, A. C. Mertens
Summary: The purpose of this study is to examine the survivor services provided by COG institutions. A survey was conducted among 209 COG member institutions, and the results showed that the majority of these institutions offer care for pediatric and young adult survivors of childhood cancer. However, less than 75% of eligible patients have access to this care due to various barriers, including lack of dedicated time and funding for program development. The study also revealed an increase in the provision of treatment summaries by institutions in 2017 compared to 2007.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Oncology
Rajkumar Venkatramani, Wei Xue, R. Lor Randall, Suzanne Wolden, James Anderson, Dolores Lopez-Terrada, Jennifer Black, Simon C. Kao, Barry Shulkin, Andrew Ostrenga, Alberto Pappo, Sheri L. Spunt
Summary: The risk-based treatment strategy used in this study showed favorable outcomes in patients with synovial sarcoma, especially in nonmetastatic cases, despite using radiation therapy less frequently and at lower doses compared to historical controls.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Matthew R. Cooperberg, Elai Davicioni, Anamaria Crisan, Robert B. Jenkins, Mercedeh Ghadessi, R. Jeffrey Karnes
Article
Oncology
Robert J. Rounbehler, Anders E. Berglund, Travis Gerke, Mandeep M. Takhar, Shivanshu Awasthi, Weimin Li, Elai Davicioni, Nicholas G. Erho, Ashley E. Ross, Edward M. Schaeffer, Eric A. Klein, R. Jeffrey Karnes, Robert B. Jenkins, John L. Cleveland, Jong Y. Park, Kosj Yamoah
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)
Article
Oncology
Robert B. Den, Felix Y. Feng, Timothy N. Showalter, Mark V. Mishra, Edouard J. Trabulsi, Costas D. Lallas, Leonard G. Gomella, W. Kevin Kelly, Ruth C. Birbe, Peter A. Mccue, Mercedeh Ghadessi, Kasra Yousefi, Elai Davicioni, Karen E. Knudsen, Adam P. Dicker
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2014)
Article
Oncology
A. E. Ross, F. Y. Feng, M. Ghadessi, N. Erho, A. Crisan, C. Buerki, D. Sundi, A. P. Mitra, I. A. Vergara, D. J. S. Thompson, T. J. Triche, E. Davicioni, E. J. Bergstralh, R. B. Jenkins, R. J. Karnes, E. M. Schaeffer
PROSTATE CANCER AND PROSTATIC DISEASES
(2014)
Article
Oncology
Travis Gerke, Himisha Beltran, Xiaodong Wang, Gwo-Shu Mary Lee, Andrea Sboner, R. Jeffrey Karnes, Eric A. Klein, Elai Davicioni, Kasra Yousefi, Ashley E. Ross, Daniela Boernigen, Curtis Huttenhower, Lorelei A. Mucci, Bruce J. Trock, Christopher J. Sweeney
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
Article
Oncology
Jose Batista da Costa, Ewan A. Gibb, Trinity J. Bivalacqua, Yang Liu, Htoo Zarni Oo, David T. Miyamoto, Mohammed Alshalalfa, Elai Davicioni, Jonathan Wright, Marc A. Dall'Era, James Douglas, Joost L. Boormans, Michiel S. Van der Heijden, Chin-Lee Wu, Bas W. G. van Rhijn, Shilpa Gupta, Petros Grivas, Kent W. Mouw, Paari Murugan, Ladan Fazli, Seong Ra, Badrinath R. Konety, Roland Seiler, Siamak Daneshmand, Omar Y. Mian, Jason A. Efstathiou, Yair Lotan, Peter C. Black
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
William S. Chen, Mohammed Alshalalfa, Shuang G. Zhao, Yang Liu, Brandon A. Mahal, David A. Quigley, Ting Wei, Elai Davicioni, Timothy R. Rebbeck, Philip W. Kantoff, Christopher A. Maher, Karen E. Knudsen, Eric J. Small, Paul L. Nguyen, Felix Y. Feng
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Martin Sjostrom, S. Laura Chang, Nick Fishbane, Elai Davicioni, Linda Hartman, Erik Holmberg, Felix Y. Feng, Corey W. Speers, Lori J. Pierce, Per Malmstrom, Marten Ferno, Per Karlsson
CLINICAL CANCER RESEARCH
(2020)
Article
Urology & Nephrology
Hanan Goldberg, Daniel Spratt, Thenappan Chandrasekar, Zachary Klaassen, Christopher J. D. Wallis, Maria Santiago-Jimenez, Nick Fishbane, Elai Davicioni, Rodrigo Noorani, Ardalan E. Ahmad, Jaime Omar Herrera Caceres, Shabbir Alibhai, Alejandro Berlin, Neil Eric Fleshner
Summary: Analyzing the impact of age on clinical-genomic prognostic features of aggressiveness in localized prostate cancer, it was found that elderly men with low-risk prostate cancer may have more aggressive disease than younger patients. This suggests a need to reconsider the standard paradigm of elderly prostate cancer patients not aggressively treated based solely on chronological age.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Oncology
Thomas Van den Broeck, Lisa Moris, Thomas Gevaert, Elai Davicioni, Bram Boeckx, Diether Lambrechts, Christine Helsen, Florian Handle, Bart Ghesquiere, Stefaan Soenen, Elien Smeets, Roy Eerlings, Sarah El Kharraz, Wout Devlies, R. Jeffrey Karnes, Tamara Lotan, Hendrik Van Poppel, Steven Joniau, Frank Claessens
Summary: This study aims to investigate the molecular drivers of metastasis in patients with high-risk localized prostate cancer. Through a retrospective matched case-control study, it was found that an increase in AZIN1 gene expression is associated with metastatic recurrence in high-risk prostate cancer patients. Further research showed that AZIN1 knockdown can affect the proliferation and metastatic potential of prostate cancer cells.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Dimple Chakravarty, Parita Ratnani, Li Huang, Zachary Dovey, Stanislaw Sobotka, Roy Berryhill, Harri Merisaari, Majd Al Shaarani, Richa Rai, Ivan Jambor, Kamlesh K. Yadav, Sandeep Mittan, Sneha Parekh, Julia Kodysh, Vinayak Wagaskar, Rachel Brody, Carlos Cordon-Cardo, Dmitry Rykunov, Boris Reva, Elai Davicioni, Peter Wiklund, Nina Bhardwaj, Sujit S. Nair, Ashutosh K. Tewari
Summary: This study demonstrates a significant association between pelvic inflammation and aggressive prostate cancer. Systemic inflammation and activation of the IL6-STAT pathway are observed in prostate cancer patients with pelvic inflammation. The study highlights the importance of monitoring prostate cancer patients with pelvic inflammation for metastasis and suggests potential therapeutic targets in inhibiting the STAT-IL6 pathway.
Article
Oncology
Nishwant Swami, Tiffany Nguyen, Ifeanyichukwu Ogobuiro, Matthew Abramowitz, Fallon Chipidza, Elai Davicioni, Karthik Meiyappan, Alan Dal Pra, Paul L. Nguyen, Alan Pollack, Sanoj Punnen, Brandon A. Mahal, Mohammed Alshalalfa
Summary: DNA damage repair (DDR) pathways are important in high-risk prostate cancer prognosis. This study investigates DDR in low-risk prostate cancer and finds that high DDR is associated with poor clinical outcome and a distinct molecular subtype.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Oncology
Radka Stoyanova, Olmo Zavala-Romero, Deukwoo Kwon, Adrian L. Breto, Isaac R. Xu, Ahmad Algohary, Mohammad Alhusseini, Sandra M. Gaston, Patricia Castillo, Oleksandr N. Kryvenko, Elai Davicioni, Bruno Nahar, Benjamin Spieler, Matthew C. Abramowitz, Alan Dal Pra, Dipen J. Parekh, Sanoj Punnen, Alan Pollack
Summary: In this study, clinical- and radiomics-based models were built to predict lesions/patients at low risk using a combined clinical-genomic classification system. Radiomic features improved the performance in all cases.
Article
Oncology
Nicholas G. Zaorsky, James A. Proudfoot, Angela Y. Jia, Raed Zuhour, Randy Vince Jr, Yang Liu, Xin Zhao, Jim Hu, Nicola C. Schussler, Jennifer L. Stevens, Suzanne Bentler, Rosemary D. Cress, Jennifer A. Doherty, Eric B. Durbin, Susan Gershman, Iona Cheng, Lou Gonsalves, Brenda Y. Hernandez, Lihua Liu, Bozena M. Morawski, Maria Schymura, Stephen M. Schwartz, Kevin C. Ward, Charles Wiggins, Xiao-Cheng Wu, Jonathan E. Shoag, Lee Ponsky, Alan Dal Pra, Edward M. Schaeffer, Ashley E. Ross, Yilun Sun, Elai Davicioni, Valentina Petkov, Daniel E. Spratt
Summary: In this study, the Decipher Prostate Genomic Classifier (GC) was used to analyze a US national database of men with prostate cancer. The use of the GC test was found to be associated with conservative management, higher rates of adverse pathology at the time of surgery, and greater use of postoperative radiotherapy.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
William A. Hall, Nick Fishbane, Yang Liu, Melody J. Xu, Elai Davicioni, Brandon A. Mahal, Robert B. Den, Robert T. Dess, William C. Jackson, Anthony C. Wong, Edward M. Schaeffer, R. Jeffrey Karnes, Peter R. Carroll, Matthew R. Cooperberg, Tarek A. Bismar, Hyung L. Kim, Eric A. Klein, John W. Davis, Ashley E. Ross, Jeffrey J. Tosoian, Todd M. Morgan, Rohit Mehra, Simpa S. Salami, Paul L. Nguyen, Colleen A. F. Lawton, Daniel E. Spratt, Felix Feng
JCO PRECISION ONCOLOGY
(2020)