Review
Oncology
Stefano Zoroddu, Irene Marchesi, Luigi Bagella
Summary: Muscle differentiation failure may involve epigenetic systems and the PRC2 complex. Research has shown that EZH2 is often deregulated in rhabdomyosarcoma and is associated with tumor malignancy.
CLINICAL EPIGENETICS
(2021)
Article
Multidisciplinary Sciences
Qiao Li, Yan Z. Mach, Munerah Hamed, Saadia Khilji, Jihong Chen
Summary: Histone acetylation and deacetylation play important roles in gene expression during cellular differentiation. The acetyltransferase p300 is essential for muscle gene expression, while histone deacetylases (HDACs) control gene repression in stem cell fate transition. The expression of Hdac11 is enhanced by nuclear receptor signaling, and it may be essential for differential gene expression during myoblast differentiation.
Article
Immunology
Anna K. Kania, Madeline J. Price, Lou-Ella George-Alexander, Dillon G. Patterson, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Summary: This study demonstrates that H3K27 demethylases inhibit B cell differentiation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Anna K. Kania, Madeline J. Price, Lou-Ella George-Alexander, Dillon G. Patterson, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Summary: In this study, it was found that the H3K27 demethylases restrain B cell differentiation. Mice with simultaneous genetic deletion of UTX and JMJD3 showed a significant increase in plasma cell formation and increased ATP synthesis capacity. Furthermore, UTX was found to regulate chromatin accessibility of known repressors of PC fate.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Yongbai Zhang, Wenpeng Huang, Liming Li, Yongkang Qiu, Hao Jiao, Zhao Chen, Qi Yang, Lele Song, Lei Kang
Summary: Retroperitoneal ARMS is a rare subtype of rhabdomyosarcoma that has aggressive behavior and a poor prognosis. Accurate diagnosis and staging using PET/CT can contribute to better risk stratifications and individualized treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Liquan Jin, Ziting Su, Shan Huang, Yunbo Tan, Isack George Mrema, Yiming Chen
Summary: This study aimed to investigate the function and expression of H3K36me3 and SETD2 during the differentiation of HOCs into cholangiocytes. HOCs were isolated from mice and cultured with specific factors. The protein levels of SETD2 and H3K36me3 were quantified, and the results showed that the expression of CK-19 increased, while OV-6 decreased, with a concurrent increase in SETD2 and H3K36me3 levels, indicating their potential involvement in differentiation.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Pharmacology & Pharmacy
Qili Liao, Jie Yang, Shengfang Ge, Peiwei Chai, Jiayan Fan, Renbing Jia
Summary: The reversible and precise regulation of histone lysine methyltransferases (KMTs) is crucial for maintaining the stability of the epigenome. Dysregulation of KMTs is associated with various aspects of cancer progression and response to treatment. In this review, the functions of KMTs and the development of targeted inhibitors are discussed, along with current targeting strategies and ongoing clinical trials.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Chemistry, Medicinal
Giulia Iannelli, Ciro Milite, Nils Marechal, Vincent Cura, Luc Bonnefond, Nathalie Troffer-Charlier, Alessandra Feoli, Donatella Rescigno, Yalong Wang, Alessandra Cipriano, Monica Viviano, Mark T. Bedford, Jean Cavarelli, Sabrina Castellano, Gianluca Sbardella
Summary: In this study, a deconstruction-reconstruction approach was used to identify potent and selective inhibitors of PRMT4. These inhibitors demonstrated a reduction in arginine methylation levels and proliferation in MCF7 cells, despite their low cell permeability. Crystal structures with various PRMTs supported the observed specificity and selectivity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Xiaolin Sun, Xiang Gu, Hongxiao Li, Pei Xu, Mengting Li, Ye Zhu, Qisheng Zuo, Bichun Li
Summary: Studies have shown that the epigenetic modifier H3K9me2 plays an important role in embryonic development, cell reprogramming, and cell differentiation. This study demonstrated that H3K9me2 is a negative regulator of cardiomyocyte formation by influencing the expression of key transcription factors, providing insights for optimizing the induction efficiency of cardiomyocytes in vitro and in clinical applications.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Lihu Gong, Xiuli Liu, Lianying Jiao, Xin Yang, Andrew Lemoff, Xin Liu
Summary: The authors identify SUZ12 as a cellular substate of casein kinase 2 (CK2) and highlight its role in promoting PRC2 function in cell identity maintenance during stem cell differentiation. This phosphorylation-dependent mechanism stimulates PRC2 enzymatic activity, enhancing its binding to substrates and promoting gene repression. Loss of this phosphorylation impairs PRC2 recruitment and compromises its ability to maintain differentiated cell identity.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Aline Renata Pavan, Juliana Romano Lopes, Jean Leandro Dos Santos
Summary: Research on drug discovery for fetal hemoglobin inducers can help design new drugs, with epigenetic enzymes regulating gamma-globin being a promising approach. Understanding the selectivity role of new drugs is crucial to reduce adverse effects.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Review
Oncology
Mengyuan Dai, Miao Liu, Hua Yang, Can Kucuk, Hua You
Summary: PD-1/PD-L1 inhibitors have shown promising outcomes in cancer treatment, but the development of resistance has decreased their effectiveness. Understanding the epigenetic mechanisms and combining epigenetic regulatory drugs with PD-1/PD-L1 inhibitors could provide a potential solution to this resistance.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Shiran Bar, Dan Vershkov, Gal Keshet, Elyad Lezmi, Naama Meller, Atilgan Yilmaz, Ofra Yanuka, Malka Nissim-Rafinia, Eran Meshorer, Talia Eldar-Geva, Nissim Benvenisty
Summary: Genetic imprinting is crucial for monoallelic gene expression in embryonic development, with differentially methylated regions playing a key role. This study used haploid parthenogenic embryonic stem cells to identify factors involved in regulating imprinted genes, highlighting the essential role of ATF7IP in repressing paternally-expressed genes.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Akhil Gargey Iragavarapu, Liqi Yao, Vignesh Kasinath
Summary: Polycomb repressive complexes are a family of chromatin modifier enzymes critical for regulating gene expression and maintaining cell-type identity. PRC2 acts as both a reader and writer of histone H3 lysine 27 trimethylation, serving as a marker for transcription repression and heterochromatin boundaries. Recent structural studies have provided insights into the roles of Polycomb cofactor proteins in mediating crosstalk between histone modifications and the recruitment of PRC2 for methyltransferase activity.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Genetics & Heredity
Jing Su, Xiushan Lin, Jianqing Zhao, Ning Zhang, Jingjing Wang, Lin Shan
Summary: This study revealed that miR-584-5p is downregulated and DPY30 is upregulated in lung cancer cells. Overexpression of miR-584-5p inhibits cell viability and protein expressions of Ki67 and PCNA. DPY30 is targeted by miR-584-5p and overexpressed DPY30 attenuates the effects of miR-584-5p.
INTERNATIONAL JOURNAL OF HUMAN GENETICS
(2022)
Article
Oncology
Minhyung Kim, Tara A. Barone, Natalia Fedtsova, Anatoli Gleiberman, Chandler D. Wilfong, Julie A. Alosi, Robert J. Plunkett, Andrei Gudkov, Joseph J. Skitzki
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Oncology
Hua Yang, Craig M. Brackett, Vanessa Marie Morales-Tirado, Zezhong Li, Qing Zhang, Matthew W. Wilson, Camille Benjamin, Wayne Harris, Edmund K. Waller, Andrei V. Gudkov, Lyudmila G. Burdelya, Hans E. Grossniklaus
Article
Oncology
Tara A. Barone, Catherine A. Burkhart, Alfiya Safina, Gary Haderski, Katerina V. Gurova, Andrei A. Purmal, Andrei V. Gudkov, Robert J. Plunkett
Article
Oncology
Richard Lock, Hernan Carol, John M. Maris, E. Anders Kolb, Richard Gorlick, C. Patrick Reynolds, Min H. Kang, Stephen T. Keir, Jianrong Wu, Andrei Purmal, Andrei Gudkov, Dias Kurmashev, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith
PEDIATRIC BLOOD & CANCER
(2017)
Article
Surgery
Minhyung Kim, Daniel T. Fisher, Colin A. Powers, Emmanuel M. Gabriel, Alexis M. Korman, Sandra Sexton, Andrei V. Gudkov, Joseph J. Skitzki
JOURNAL OF SURGICAL RESEARCH
(2017)
Article
Multidisciplinary Sciences
David Frescas, Christelle M. Roux, Semra Aygun-Sunar, Anatoli S. Gleiberman, Peter Krasnov, Oleg V. Kurnasov, Evguenia Strom, Lauren P. Virtuoso, Michelle Wrobel, Andrei L. Osterman, Marina P. Antoch, Vadim Mett, Olga B. Chernova, Andrei V. Gudkov
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biology
Ilia A. Toshkov, Anatoli S. Gleiberman, Vadim L. Mett, Alan D. Hutson, Anurag K. Singh, Andrei V. Gudkov, Lyudmila G. Burdelya
RADIATION RESEARCH
(2017)
Article
Chemistry, Analytical
Balamurugan Tharmalingam, Moorthy Mathivanan, Kailasam Saravana Mani, Werner Kaminsky, Azhwar Raghunath, Mathivanan Jothi, Ekambaram Perumal, Balasubramanian Murugesapandian
ANALYTICA CHIMICA ACTA
(2020)
Article
Spectroscopy
Kailasam Saravana Mani, Ramar Rajamanik, Malaichamy Ilanchelian, Narenkumar Muralidharan, Mathivanan Jothi, Subramaniam Parameswaran Rajendran
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Cell Biology
Narenkumar Muralidharan, Abinayaselvi Murugan, Prabhuraj Andiperumal Raj, Mathivanan Jothi
Summary: The PAX3 transcription factor is involved in the differentiation defects observed in neuroblastoma, with the PAX3b isoform being responsible for the defect in SK-N-SH cells. Restoring functional PAX3 in the absence of PAX3b can induce neurogenesis in these cells.
CELL AND TISSUE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Moorthy Mathivanan, Balamurugan Tharmalingam, Thangaraj Devaraj, Abinayaselvi Murugan, Chia-Her Lin, Mathivanan Jothi, Balasubramanian Murugesapandian
Summary: The newly developed 7-diethylamino-4-hydroxycoumarin appended acylhydrazone probe can selectively detect Al3+ metal ions and aluminum ions in pharmaceutical tablets. Moreover, it can be used for detecting pyrophosphate (PPi) anions and has applications in constructing molecular logic gates and on-site detection kits.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Cell Biology
Alexey Moskalev, Vladimir Anisimov, Aleksander Aliper, Artem Artemov, Khusru Asadullah, Daniel Belsky, Ancha Baranova, Aubrey de Grey, Vishwa Deep Dixit, Edouard Debonneuil, Eugenia Dobrovolskaya, Peter Fedichev, Alexander Fedintsev, Vadim Fraifeld, Claudio Franceschi, Rosie Freer, Tamas Fueloep, Jerome Feige, David Gems, Vadim Gladyshev, Vera Gorbunova, Irina Irincheeva, Sibylle Jager, S. Michal Jazwinski, Matt Kaeberlein, Brian Kennedy, Daria Khaltourina, Igor Kovalchuk, Olga Kovalchuk, Sergey Kozin, Alexander Kulminski, Ekaterina Lashmanova, Ksenia Lezhnina, Guang-Hui Liu, Valter Longo, Polina Mamoshina, Alexander Maslov, Joao Pedro de Magalhaes, James Mitchell, Arnold Mitnitski, Yuri Nikolsky, Ivan Ozerov, Elena Pasyukova, Darya Peregudova, Vasily Popov, Ekaterina Proshkina, Evgeny Putin, Evgeny Rogaev, Blanka Rogina, Jane Schastnaya, Andrey Seluanov, Mikhail Shaposhnikov, Andreas Simm, Vladimir Skulachev, Maxim Skulachev, Ilya Solovev, Stephen Spindler, Natalia Stefanova, Yousin Suh, Andrew Swick, John Tower, Andrei V. Gudkov, Jan Vijg, Andrey Voronkov, Michael West, Wolfgang Wagner, Anatoliy Yashin, Nadezhda Zemskaya, Zhaxybay Zhumadilov, Alex Zhavoronkov
Article
Cell Biology
David Frescas, Brandon M. Hall, Evguenia Strom, Lauren P. Virtuoso, Mahima Gupta, Anatoli S. Gleiberman, Elena Rydkina, Vitaly Balan, Slavoljub Vujcic, Olga B. Chernova, Andrei V. Gudkov
Article
Cell Biology
Brandon M. Hall, Vitaly Balan, Anatoli S. Gleiberman, Evguenia Strom, Peter Krasnov, Lauren P. Virtuoso, Elena Rydkina, Slavoljub Vujcic, Karina Balan, Ilya I. Gitlin, Katerina I. Leonova, Camila R. Consiglio, Sandra O. Gollnick, Olga B. Chernova, Andrei V. Gudkov
Article
Cell Biology
Marina P. Antoch, Michelle Wrobel, Karen K. Kuropatwinski, Ilya Gitlin, Katerina I. Leonova, Ilia Toshkov, Anatoli S. Gleiberman, Alan D. Hutson, Olga B. Chernova, Andrei V. Gudkov