Riluzole

Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block

(2011) Alessandra Cifra et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Riluzole decreases flexion withdrawal reflex but not voluntary ankle torque in human chronic spinal cord injury

(2011) Renée D. Theiss et al.   JOURNAL OF NEUROPHYSIOLOGY

Electrochemical detection of endogenous glutamate release from rat spinal cord organotypic slices as a real-time method to monitor excitotoxicity

(2011) Graciela L. Mazzone et al.   JOURNAL OF NEUROSCIENCE METHODS

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

(2011) Marica Carbone et al.   NEUROCHEMISTRY INTERNATIONAL

Delayed neuroprotection by riluzole against excitotoxic damage evoked by kainate on rat organotypic spinal cord cultures

(2011) G.L. Mazzone et al.   NEUROSCIENCE

Supply and demand for endocannabinoids

(2011) Bradley E. Alger et al.   TRENDS IN NEUROSCIENCES

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

A Review of the Neural Mechanisms of Action and Clinical Efficiency of Riluzole in Treating Amyotrophic Lateral Sclerosis: What have we Learned in the Last Decade?

(2010) Mark C. Bellingham   CNS Neuroscience & Therapeutics

Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis

(2010) B.C. Cheah et al.   CURRENT MEDICINAL CHEMISTRY

Motoneuron Excitability and Muscle Spasms Are Regulated by 5-HT2B and 5-HT2C Receptor Activity

(2010) Katherine C. Murray et al.   JOURNAL OF NEUROPHYSIOLOGY

A Systematic Review of Non-Invasive Pharmacologic Neuroprotective Treatments for Acute Spinal Cord Injury

(2010) Brian K. Kwon et al.   JOURNAL OF NEUROTRAUMA

Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

(2010) Pascale Boulenguez et al.   NATURE MEDICINE

Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord

(2010) G.L. Mazzone et al.   NEUROSCIENCE

Riluzole blocks persistent Na+and Ca2+currents and modulates release of glutamate via presynaptic NMDA receptors on neonatal rat hypoglossal motoneuronsin vitro

(2008) Nerijus Lamanauskas et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

(2008) B. van Zundert et al.   JOURNAL OF NEUROSCIENCE

Kainate and metabolic perturbation mimicking spinal injury differentially contribute to early damage of locomotor networks in the in vitro neonatal rat spinal cord

(2008) G. Taccola et al.   NEUROSCIENCE

Diagnosis and treatment of bulbar symptoms in amyotrophic lateral sclerosis

(2008) Peter Kühnlein et al.   Nature clinical practice. Neurology

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

(2007) Elena Fumagalli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY