Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis

(2012) Renzo Mancuso et al.   Amyotrophic Lateral Sclerosis

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

(2011) Amr Al-Saif et al.   ANNALS OF NEUROLOGY

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

(2011) Siranush A Sargsyan et al.   BMC NEUROSCIENCE

Evolution of gait abnormalities in SOD1G93A transgenic mice

(2011) Renzo Mancuso et al.   BRAIN RESEARCH

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats

(2011) Mohammad Allahtavakoli et al.   BRAIN RESEARCH BULLETIN

Electrophysiological analysis of a murine model of motoneuron disease

(2011) Renzo Mancuso et al.   CLINICAL NEUROPHYSIOLOGY

Sigma Receptor Agonist 2-(4-Morpholinethyl)1 Phenylcyclohexanecarboxylate (Pre084) Increases GDNF and BiP Expression and Promotes Neuroprotection after Root Avulsion Injury

(2011) Clara Penas et al.   JOURNAL OF NEUROTRAUMA

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Sera from amyotrophic lateral sclerosis patients induce the non-canonical activation of NMDA receptors “in vitro”

(2011) Laura Texidó et al.   NEUROCHEMISTRY INTERNATIONAL

Activation of the sigma receptor 1 suppresses NMDA responses in rat retinal ganglion cells

(2011) X.-J. Zhang et al.   NEUROSCIENCE

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease

(2010) Agnes A. Luty et al.   ANNALS OF NEUROLOGY

Reduction in the Motoneuron Inhibitory/Excitatory Synaptic Ratio in an Early-Symptomatic Mouse Model of Amyotrophic Lateral Sclerosis

(2010) Carmen R. Sunico et al.   BRAIN PATHOLOGY

Calcium dysregulation in amyotrophic lateral sclerosis

(2010) Julian Grosskreutz et al.   CELL CALCIUM

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy

(2009) María Moreno-Igoa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Cytoskeletal and Activity-Related Changes in Spinal Motoneurons after Root Avulsion

(2009) Clara Penas et al.   JOURNAL OF NEUROTRAUMA

Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons

(2009) M.-S. Guzmán-Lenis et al.   NEUROSCIENCE

SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression

(2009) Tuerhong Tuerxun et al.   NEUROSCIENCE LETTERS

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sigma receptors suppress multiple aspects of microglial activation

(2008) Aaron A. Hall et al.   GLIA

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

(2008) K. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY