Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury
出版年份 2014 全文链接
标题
Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury
作者
关键词
Traumatic brain injury, Metabotropic glutamate receptor 5, Positive allosteric modulator, Neuroprotection, Functional recovery, Microglial activation
出版物
Neurotherapeutics
Volume 11, Issue 4, Pages 857-869
出版商
Springer Nature
发表日期
2014-08-05
DOI
10.1007/s13311-014-0298-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Positive Allosteric Modulators (PAMs) of Metabotropic Glutamate Receptor 5 (mGluR5) Attenuate Microglial Activation
- (2014) Fengtian Xue et al. CNS & Neurological Disorders-Drug Targets
- Progressive Neurodegeneration After Experimental Brain Trauma
- (2013) David J. Loane et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Development of allosteric modulators of GPCRs for treatment of CNS disorders
- (2013) Hilary Highfield Nickols et al. NEUROBIOLOGY OF DISEASE
- Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats
- (2012) Jia-Wei Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
- (2012) Kimberly R Byrnes et al. Journal of Neuroinflammation
- Comparing the Predictive Value of Multiple Cognitive, Affective, and Motor Tasks after Rodent Traumatic Brain Injury
- (2012) Zaorui Zhao et al. JOURNAL OF NEUROTRAUMA
- Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury
- (2012) David J. Loane et al. JOURNAL OF NEUROTRAUMA
- Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
- (2012) Alok Kumar et al. NEUROBIOLOGY OF AGING
- Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection
- (2011) Thomas M. Piers et al. NEUROSCIENCE LETTERS
- Group 5 metabotropic glutamate receptors: Role in modulating cortical activity and relevance to cognition
- (2010) Houman Homayoun et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction
- (2010) M. Foster Olive EUROPEAN JOURNAL OF PHARMACOLOGY
- Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity
- (2010) A. L. Rodriguez et al. MOLECULAR PHARMACOLOGY
- Metabotropic glutamate receptors: From the workbench to the bedside
- (2010) F. Nicoletti et al. NEUROPHARMACOLOGY
- Microglial activation and chronic neurodegeneration
- (2010) Melinda E. Lull et al. Neurotherapeutics
- Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
- (2009) Kimberly R. Byrnes et al. ANNALS OF NEUROLOGY
- Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase
- (2009) David J. Loane et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
- (2009) Carol A. Colton Journal of Neuroimmune Pharmacology
- The Multifaceted Profile of Activated Microglia
- (2009) Marina A. Lynch MOLECULAR NEUROBIOLOGY
- Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
- (2009) David J Loane et al. NATURE MEDICINE
- mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning
- (2009) Jennifer E Ayala et al. NEUROPSYCHOPHARMACOLOGY
- Positive Allosteric Modulation of mGluR5 Receptors Facilitates Extinction of a Cocaine Contextual Memory
- (2008) Justin T. Gass et al. BIOLOGICAL PSYCHIATRY
- Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
- (2008) Kimberly R. Byrnes et al. GLIA
- Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats
- (2008) Andreas Gravius et al. JOURNAL OF NEURAL TRANSMISSION
- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
- (2008) P. Jeffrey Conn et al. NATURE REVIEWS DRUG DISCOVERY
- Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
- (2008) Kimberly R. Byrnes et al. Neurotherapeutics
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More