Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury

(2012) Jia-Wei Wang et al.   BRAIN RESEARCH

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

(2012) Kimberly R Byrnes et al.   Journal of Neuroinflammation

Protective Effects of mGluR5 Positive Modulators Against Traumatic Neuronal Injury Through PKC-Dependent Activation of MEK/ERK Pathway

(2012) Tao Chen et al.   NEUROCHEMICAL RESEARCH

Critical Role of NADPH Oxidase in Neuronal Oxidative Damage and Microglia Activation following Traumatic Brain Injury

(2012) Quan-Guang Zhang et al.   PLoS One

The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway

(2011) TAO CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NADPH oxidase is involved in post-ischemic brain inflammation

(2011) Hai Chen et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions

(2010) Janelle Drouin-Ouellet et al.   GLIA

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

(2010) Teuntje M. J. C. Andriessen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

(2010) David J. Loane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

(2009) Kimberly R. Byrnes et al.   ANNALS OF NEUROLOGY

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury

(2009) David J Loane et al.   NATURE MEDICINE

Evidence Group I mGluR Drugs Modulate the Activation Profile of Lipopolysaccharide-Exposed Microglia in Culture

(2009) Mark C. Farso et al.   NEUROCHEMICAL RESEARCH

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

Multifunctional drugs for head injury

(2008) Robert Vink et al.   Neurotherapeutics

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

(2008) Kimberly R. Byrnes et al.   Neurotherapeutics