Synapse Assembly and Neurodevelopmental Disorders

Autism-Related Neuroligin-3 Mutation Alters Social Behavior and Spatial Learning

(2014) Thomas C. Jaramillo et al.   Autism Research

Association ofGSK-3βGenetic Variation With GSK-3β Expression, Prefrontal Cortical Thickness, Prefrontal Physiology, and Schizophrenia

(2013) Giuseppe Blasi et al.   AMERICAN JOURNAL OF PSYCHIATRY

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

Neuroligin1 Drives Synaptic and Behavioral Maturation through Intracellular Interactions

(2013) J. L. Hoy et al.   JOURNAL OF NEUROSCIENCE

Membrane-Tethered Monomeric Neurexin LNS-Domain Triggers Synapse Formation

(2013) O. Gokce et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Threonine-19 of PSD-95 by GSK-3  is Required for PSD-95 Mobilization and Long-Term Depression

(2013) C. D. Nelson et al.   JOURNAL OF NEUROSCIENCE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Altered Social Behaviours in Neurexin 1α Knockout Mice Resemble Core Symptoms in Neurodevelopmental Disorders

(2013) Hannah Mary Grayton et al.   PLoS One

Late Recruitment of Synapsin to Nascent Synapses Is Regulated by Cdk5

(2013) Courtney Easley-Neal et al.   Cell Reports

SHANK1 Deletions in Males with Autism Spectrum Disorder

(2012) Daisuke Sato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fragile X Syndrome

(2012) Yingratana McLennan et al.   CURRENT GENOMICS

Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications

(2012) Alfredo Ramos-Miguel et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization

(2012) Lucas Cheadle et al.   JOURNAL OF CELL BIOLOGY

MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain

(2012) M. V. C. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Regulation of NMDA Receptor Transport: A KIF17-Cargo Binding/Releasing Underlies Synaptic Plasticity and Memory In Vivo

(2012) X. Yin et al.   JOURNAL OF NEUROSCIENCE

Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1

(2012) Bernhard M. Kohli et al.   JOURNAL OF PROTEOME RESEARCH

Clue to an ancient cosmic-ray event?

(2012) Jonathon Allen   NATURE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number

(2012) Hyung-Bae Kwon et al.   NATURE NEUROSCIENCE

Sex-Dependent Novelty Response in Neurexin-1α Mutant Mice

(2012) Marijke C. Laarakker et al.   PLoS One

Deregulated mTOR-mediated translation in intellectual disability

(2012) José Antonio Troca-Marín et al.   PROGRESS IN NEUROBIOLOGY

Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

(2012) S. J. Baudouin et al.   SCIENCE

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

(2012) Claire S. Leblond et al.   PLoS Genetics

Brain abnormalities in a Neuroligin3 R451C knockin mouse model associated with autism

(2011) Jacob Ellegood et al.   Autism Research

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

(2011) Olivia Engmann et al.   BRAIN

SnapShot: Autism and the Synapse

(2011) João Peça et al.   CELL

An Update on Gene Therapy in Parkinson’s Disease

(2011) Jennifer Witt et al.   Current Neurology and Neuroscience Reports

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

(2011) Mark R Etherton et al.   EMBO JOURNAL

A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis

(2011) Leonhard Lennertz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Tau's role in the developing brain: implications for intellectual disability

(2011) Tamar Sapir et al.   HUMAN MOLECULAR GENETICS

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Functional dependence of neuroligin on a new non-PDZ intracellular domain

(2011) Seth L Shipman et al.   NATURE NEUROSCIENCE

Coordinated trafficking of synaptic vesicle and active zone proteins prior to synapse formation

(2011) Luke AD Bury et al.   Neural Development

CYY-1/Cyclin Y and CDK-5 Differentially Regulate Synapse Elimination and Formation for Rewiring Neural Circuits

(2011) Mikyoung Park et al.   NEURON

SnapShot: Genetics of Autism

(2011) Kimberly A. Aldinger et al.   NEURON

The role of neurexins in schizophrenia and autistic spectrum disorder

(2011) A.C. Reichelt et al.   NEUROPHARMACOLOGY

Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior

(2011) Markus Wöhr et al.   PLoS One

A Brain Region-Specific Predictive Gene Map for Autism Derived by Profiling a Reference Gene Set

(2011) Ajay Kumar et al.   PLoS One

The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo

(2011) G. J. Soler-Llavina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

(2011) Andreas M. Grabrucker et al.   TRENDS IN CELL BIOLOGY

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts

(2010) Philip Awadalla et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synaptopathy: dysfunction of synaptic function?

(2010) Nils Brose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

De Novo Truncating Mutation in Kinesin 17 Associated with Schizophrenia

(2010) Julien Tarabeux et al.   BIOLOGICAL PSYCHIATRY

Sociability and motor functions in Shank1 mutant mice

(2010) Jill L. Silverman et al.   BRAIN RESEARCH

Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

(2010) Takeshi Uemura et al.   CELL

Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus

(2010) Regina Dahlhaus et al.   HIPPOCAMPUS

Neurexins, Neuroligins and LRRTMs: synaptic adhesion getting fishy

(2010) Gavin J. Wright et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes Prevent Abnormal Neuronal Development in the Fragile X Mouse

(2010) S. Jacobs et al.   JOURNAL OF NEUROSCIENCE

LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development

(2010) T. J. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

(2010) C O'Dushlaine et al.   MOLECULAR PSYCHIATRY

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

(2010) Simone Berkel et al.   NATURE GENETICS

SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning

(2010) Elissa M. Robbins et al.   NEURON

Neurexins Physically and Functionally Interact with GABAA Receptors

(2010) Chen Zhang et al.   NEURON

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

A Genome-Wide Association Study of Neuroticism in a Population-Based Sample

(2010) Federico C. F. Calboli et al.   PLoS One

SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones

(2010) M. Stagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cbln1 Is a Ligand for an Orphan Glutamate Receptor  2, a Bidirectional Synapse Organizer

(2010) K. Matsuda et al.   SCIENCE

Key role for gene dosage and synaptic homeostasis in autism spectrum disorders

(2010) Roberto Toro et al.   TRENDS IN GENETICS

Neuronal cell adhesion genes

(2010) Aiden P. Corvin   Cell Adhesion & Migration

A synaptic trek to autism

(2009) Thomas Bourgeron   CURRENT OPINION IN NEUROBIOLOGY

CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes

(2009) Anna Hackett et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit

(2009) K. Radyushkin et al.   GENES BRAIN AND BEHAVIOR

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

(2009) Joseph T. Glessner et al.   NATURE

Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

(2009) Nurit Ballas et al.   NATURE NEUROSCIENCE

Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis

(2009) Stephanie L Barrow et al.   Neural Development

An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers

(2009) Michael W. Linhoff et al.   NEURON

LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

(2009) Joris de Wit et al.   NEURON

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

(2009) Jaewon Ko et al.   NEURON

Mouse neurexin-1  deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

(2009) M. R. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TheCASKgene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation

(2008) Shin Hayashi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice

(2008) Kathryn K. Chadman et al.   Autism Research

Mutations in the gene encoding CADM1 are associated with autism spectrum disorder

(2008) Yu Zhiling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Unusual Member of the Cdk Family: Cdk5

(2008) Fatema A. Dhariwala et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Genetics and Molecular Biology of Tuberous Sclerosis Complex

(2008) Valerio Napolioni et al.   CURRENT GENOMICS

Axonal transport and the delivery of pre-synaptic components

(2008) Ann YN Goldstein et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

(2008) Klaus-Peter Lesch et al.   JOURNAL OF NEURAL TRANSMISSION

Developmental Control of Synaptic Receptivity

(2008) A. J. Barker et al.   JOURNAL OF NEUROSCIENCE

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum

(2008) Juliane Najm et al.   NATURE GENETICS

Surface trafficking of N-methyl-d-aspartate receptors: Physiological and pathological perspectives

(2008) L. Groc et al.   NEUROSCIENCE

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

(2008) S. Jamain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA