Review
Neurosciences
Paul J. Banks, Zafar Bashir
Summary: This review focuses on the roles played by N-methyl-D-aspartate receptors (NMDARs) on pyramidal neurons in the medial prefrontal cortex, including their frequency-dependent effects on ongoing synaptic transmission, plasticity, and contribution to plasticity induced by synchronous activation of two separate inputs to the mPFC.
Review
Clinical Neurology
Ja Eun Choi, Bong-Kiun Kaang
Summary: The brain has the ability to transform experiences into anatomic maps and integrate massive amounts of information to form new memories. Dendritic spines are believed to be the structural basis of information storage and are associated with learning and memory. Advancements in techniques allow for more precise investigation of dendritic spines and provide clues about how memories reside in them.
Article
Neurosciences
Nastaran Golitabari, Forouzan Mohammadian, Ali-Akbar Salari, Mohammad Amani
Summary: This study found that early life exposure to PCP can negatively affect the synaptic function of CA1 neurons in the hippocampus of adult rats, including inhibiting long-term potentiation and depression, and causing significant changes in complex response profiles.
Article
Chemistry, Multidisciplinary
Guang-ying Li, Qiu-zi Wu, Tian-jia Song, Xue-chu Zhen, Xiang Yu
Summary: Normal brain function relies on the complex neural network, which is formed and maintained through synaptogenesis and synaptic plasticity. Deficiency in growth hormone can lead to brain development abnormalities and impair learning and memory, while growth hormone replacement therapy has been shown to ameliorate cognitive deficits. However, the underlying mechanism is still largely unknown.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Kevin M. Keary III, Qin-Hua Gu, Jiji Chen, Zheng Li
Summary: The mechanism of long-term depression (LTD) is extensively studied in Schaffer collateral (SC) synapses, and inhibition of autophagy is identified as a key factor. Here, it is demonstrated that the temporoammonic pathway (TAP) and SC synapses have a shared LTD mechanism reliant on NMDA receptors, caspase-3, and autophagy inhibition. The distribution of autophagosomes in dendrites and distinct LTD induction at SC and TAP synapses suggest a model where autophagosomes gate LTD inducibility.
Review
Environmental Sciences
Yifeng Rang, Huan Liu, Chunhong Liu
Summary: This review summarizes the mechanisms underlying Nonylphenol (NP)-induced learning and memory impairment and proposes possible therapeutic methods. Through behavior tests and other studies, oxidative stress, neurotransmitter disorder, synaptic plasticity impairment, and neuron injury are identified as key factors contributing to learning and memory deficits. In addition, chronic inflammation and increased gut permeability are also suggested to be associated with NP-induced learning and memory impairment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Physics, Fluids & Plasmas
Wenxuan Zou, Chan Li, Haiping Huang
Summary: In this study, the authors propose a spike and slab distribution to model the individual connections in recurrent neural networks for temporal credit assignment. They derive a mean-field algorithm to train the network and apply the method to classification and multisensory integration tasks. The study uncovers important connections in the network and reveals different types of neural selectivity.
Article
Biology
Haneen Kayyal, Sailendrakumar Kolatt Chandran, Adonis Yiannakas, Nathaniel Gould, Mohammad Khamaisy, Kobi Rosenblum
Summary: The research reveals the vital role of reciprocal connectivity between the anterior insular cortex and the medial prefrontal cortex in animals' experience of novel taste, fear response, and learning, providing important insights for understanding related psychiatric disorders.
Article
Neurosciences
Alexandra B. Nelson, Allison E. Girasole, Hsien-Yang Lee, Louis J. Ptacek, Anatol C. Kreitzer
Summary: Abnormal involuntary movements, or dyskinesias, are observed in various neurologic disorders, and may be caused by alterations in neural activity or connectivity. This study shows that dysfunction in the indirect pathway of the striatum contributes to the development of dyskinesia in a mouse model, suggesting that hypoactivity in the indirect pathway may be a key mechanism for involuntary movements in other disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Abdallah Ahnaou, Kobe Heleven, Ria Biermans, Nikolay Manyakov, Wilhelmus H. Drinkenburg
Summary: This study highlights the importance of NMDAR in LTP synaptic plasticity, but specific blockade of the NR2B subunit does not alter hippocampal LTP. Pharmacokinetics at the doses used may have contributed to the lack of effects with specific antagonists.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Xingzhi He, Jiarui Li, Guangjun Zhou, Jing Yang, Sam McKenzie, Yanjun Li, Wenwen Li, Jun Yu, Yang Wang, Jing Qu, Zhiying Wu, Hailan Hu, Shumin Duan, Huan Ma
Summary: This study shows a positive correlation between hippocampal oscillatory strength and excitatory monosynaptic drive onto inhibitory neurons in freely behaving mice. By manipulating experience-dependent E -> I synaptic input/plasticity, the researchers were able to demonstrate its role in memory function. Deleting a specific protein affected long-term memory and brain wave rhythms.
Review
Cell Biology
Jessica Cornell, Shelbi Salinas, Hou-Yuan Huang, Miou Zhou
Summary: Microglia are resident macrophages of the central nervous system with diverse morphologies and functions. Resting microglia play a crucial role in regulating synaptic pruning and neuronal activity under normal conditions, while activated microglia secrete proteins that can lead to synaptic plasticity and cognitive deficits associated with various diseases and disorders. This review discusses the role of microglia in synaptic plasticity and learning and memory, as well as the potential of manipulating microglia as a therapeutic approach to alleviate cognitive deficits.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Wanqiu Niu, Yanhong Duan, Yu Kang, Xiaohua Cao, Qingsheng Xue
Summary: This study investigated the effect of propofol on fear memory extinction and synaptic plasticity in a PTSD mice model. The results showed that propofol can accelerate fear memory extinction and restore impaired synaptic plasticity in the hippocampus of PTSD mice.
Article
Multidisciplinary Sciences
Zhongrong Wang, Wei Wang, Pan Liu, Gongjie Liu, Jiahang Li, Jianhui Zhao, Zhenyu Zhou, Jingjuan Wang, Yifei Pei, Zhen Zhao, Jiaxin Li, Lei Wang, Zixuan Jian, Yichao Wang, Jianxin Guo, Xiaobing Yan
Summary: A high-performance, superlow power consumption memristor device based on WSe2 quantum dots is demonstrated, showing excellent resistive switching memory behavior and good stability. The device is able to simulate different functions of artificial synapses and has high accuracy in digit recognition, paving the way for future low power neuromorphic computing.
Article
Neurosciences
Dany Khamsing, Solene Lebrun, Isabelle Fanget, Nathanael Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, Francois Darchen, Claire Desnos
Summary: Memory and long term potentiation rely on de novo protein synthesis, with mTORC1 playing a key role in this process. In neuronal cells, NMDA receptor activation triggers mTOR translocation to lysosomes, with a possible contribution from BDNF through the TrkB receptor. Optogenetic tools can provide spatial and temporal control over mTOR localization, revealing a functional link between NMDA receptors and mTORC1 activation.
Article
Neurosciences
Atena Farkhondeh, Shinsuke Niwa, Yosuke Takei, Nobutaka Hirokawa
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Yosuke Takei, Yayoi S. Kikkawa, Nafiseh Atapour, Takao K. Hensch, Nobutaka Hirokawa
JOURNAL OF NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araujo Goncalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A. A. Vignali, Valina L. Dawson, Han Seok Ko, Ted M. Dawso
Article
Cell Biology
Jin-Chong Xu, Jing Fan, Xueqing Wang, Stephen M. Eacker, Tae-In Kam, Li Chen, Xiling Yin, Juehua Zhu, Zhikai Chi, Haisong Jiang, Rong Chen, Ted M. Dawson, Valina L. Dawson
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Cell Biology
George K. E. Umanah, Marco Pignatelli, Xiling Yin, Rong Chen, Joshua Crawford, Stewart Neifert, Leslie Scarffe, Adam A. Behensky, Noah Guiberson, Melissa Chang, Erica Ma, Jin Wan Kim, Cibele C. Castro, Xiaobo Mao, Li Chen, Shaida A. Andrabi, Mikhail V. Pletnikov, Ann E. Pulver, Dimitrios Avramopoulos, Antonello Bonci, David Valle, Ted M. Dawson, Valina L. Dawson
SCIENCE TRANSLATIONAL MEDICINE
(2017)
Article
Multidisciplinary Sciences
Sangjune Kim, Seung Pil Yun, Saebom Lee, George Essien Umanah, Veera Venkata Ratnam Bandaru, Xiling Yin, Peter Rhee, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Hojae Lee, Xiaobo Mao, Donghoon Kim, Akhilesh Pandey, Gabsang Lee, Valina L. Dawson, Ted M. Dawson, Han Seok Ko
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Neurosciences
Makoto Kondo, Yosuke Takei, Nobutaka Hirokawa
Article
Multidisciplinary Sciences
Xiuping Fu, Duochun Wang, Xiling Yin, Pengcheng Du, Biao Kan
Article
Cell & Tissue Engineering
Jungwoo Wren Kim, Xiling Yin, Aanishaa Jhaldiyal, Mohammed Repon Khan, Ian Martin, Zhong Xie, Tamara Perez-Rosello, Manoj Kumar, Leire Abalde-Atristain, Jinchong Xu, Li Chen, Stephen M. Eacker, D. James Surmeier, Nicholas T. Ingolia, Ted M. Dawson, Valina L. Dawson
Article
Anatomy & Morphology
Fumihiro Shutoh, Tomoyuki Masuda, Tetsuya Sasaki, Yosuke Takei
Summary: This report presents a rare case of PLSVC with anomalous atrium discovered during a student dissection session, highlighting interesting variations in the anatomical structure of the heart that may have developmental and clinical implications.
ANATOMICAL SCIENCE INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Suguru Iwata, Momo Morikawa, Yosuke Takei, Nobutaka Hirokawa
Article
Neurosciences
Tetsuya Sasaki, Rei Nagata, Satoru Takahashi, Yosuke Takei
Summary: Our study found that continuous increase of IL-17A resulting from ROR gamma t overexpression led to decreased microglia activity in the dentate gyrus of the brain, but had only a subtle effect on murine hippocampal functions. The expression levels of synaptic proteins and the novel object location test results showed no significant differences between ROR gamma t Tg and wild-type mice.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2021)
Article
Neurosciences
Xiling Yin, Jin-Chong Xu, Gun-sik Cho, Chulan Kwon, Ted M. Dawson, Valina L. Dawson
Meeting Abstract
Cell Biology
Y. Takei, Y. Kikkawa, N. Atapour, T. Hensch, N. Hirokawa
MOLECULAR BIOLOGY OF THE CELL
(2013)
