Article
Chemistry, Medicinal
Hong-He Xiao, Ji-Cong Chen, He Li, Rui-Hai Li, Hai-Bo Wang, Hui-Peng Song, Hong-Yan Li, Guo-Shun Shan, Yu Tian, Yu-Meng Zhao, Jin-Ming Tian, Jing-Xian Yang
Summary: The study demonstrated that ICS II could improve neurogenesis dysfunction and inhibit mitochondrial fission by activating the Wnt/beta-catenin signaling pathway, thereby promoting the restoration of cognitive function in APP/PS1 mice.
PHYTOTHERAPY RESEARCH
(2022)
Article
Neurosciences
Victoria Gomez-Murcia, Kevin Carvalho, Bryan Thiroux, Raphaelle Caillierez, Melanie Besegher, Nicolas Sergeant, Luc Buee, Emile Faivre, David Blum
Summary: Due to the complexity of Alzheimer's disease, it is of interest to find multitarget approaches that can mitigate multiple pathogenic mechanisms. In this study, the potential of Doxycycline (Dox), a second-generation tetracycline, in the APP/PS1 mouse model of amyloidogenesis was evaluated. The results showed that Dox moderately improved spatial memory in APP/PS1 mice without major effect on amyloid lesions. The study also found that Dox enhanced the amyloid-dependent upregulation of neuroinflammatory markers. Overall, chronic Dox delivery did not provide significant pathophysiological improvements in the APP/PS1 mouse model.
Article
Food Science & Technology
Huan-Huan Zhou, Lan Luo, Xue-Di Zhai, Liangkai Chen, Guiping Wang, Li-Qiang Qin, Zengli Yu, Li-Li Xin, Zhongxiao Wan
Summary: This study demonstrates that dietary advanced glycation end products (dAGEs) impair cognitive function only in female mice, and trehalose can protect neurofunction by modulating the glycogen synthase kinase-3 beta (GSK3 beta)-transcription factor EB (TFEB) signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Engineering, Biomedical
Nelda Antonovaite, Lianne A. Hulshof, Christiaan F. M. Huffels, Elly M. Hol, Wytse J. Wadman, Davide Iannuzzi
Summary: Evidence of altered tissue mechanics in neurodegeneration is increasing, especially in Alzheimer's disease. Viscoelastic differences have been found in the brain tissue of APP/PS1 mice compared to wild-type mice, with regions in the hippocampus showing increased stiffness and viscous dissipation. Despite overall mechanical heterogeneity, local alterations in stiffness were not observed at the cellular scale around the plaques.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yang
Summary: This study demonstrates that tanshinone IIA (tan IIA) can ameliorate cognitive decline and tau pathology in APP/PS1 mice by modulating the PI3K/Akt/GSK-3β signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Jiawei Zhang, Yaling Zheng, Yao Zhao, Yaxuan Zhang, Yu Liu, Fang Ma, Xiuzhe Wang, Jianliang Fu
Summary: Andrographolide can significantly alleviate cognitive impairments, reduce amyloid-β deposition, inhibit microglial activation, and decrease the secretion of proinflammatory factors in APP/PS1 mice. Furthermore, transcriptome sequencing analysis revealed that Andro could significantly decrease the expression of various genes associated with inflammation in APP/PS1 mice, which was further validated by qRT-PCR. Our results suggest that Andro might be a potential therapeutic drug for AD by regulating neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Xiaolin Zhang, Ning Shen, Minghua Li, Jianfeng Cai, Marcia Gordon, David Morgan, Qingyu Zhou, Chuanhai Cao
Summary: This study aimed to investigate the therapeutic effect of low-dose delta-9-tetrahydrocannabinol (THC) in Alzheimer's disease (AD). The results showed that low-dose THC can reduce amyloid-beta aggregation and improve spatial learning in aged AD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Juan Jose Fernandez-Valenzuela, Vanessa De Castro, Marina Mejias-Ortega, Angela Gomez-Arboledas, Sebastian Jimenez, Maria Virtudes Sanchez-Mico, Laura Trujillo-Estrada, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez
Summary: Alzheimer's disease is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. Synaptic dysfunction and loss have been established as the pathological features that best correlate with the typical early cognitive decline in this disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Liangyun Liu, Jianing Cao, Chujun Huang, Erdong Yuan, Jiaoyan Ren
Summary: Cognitive impairment is a major clinical feature in AD patients, but research suggests peripheral organs may also play a role in AD pathology. Studies on aged APP/PS1 mice show increased inflammation response and decreased anti-oxidative capacity in peripheral organs, highlighting the need for a more comprehensive approach to studying AD.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Food Science & Technology
Yue-Qin Zeng, Juan-Hua Gu, Liang Chen, Tao-Tao Zhang, Xin-Fu Zhou
Summary: The study showed that chronic administration of gastrodin can decrease aggregation of A beta 42, prevent A beta 42 induced neurotoxicity, reduce levels of A beta plaques and hyperphosphorylated tau, alleviate activation of glial cells and proinflammatory cytokines, and attenuate oxidative stress in the APP/PS1 transgenic mice. The potential mechanisms involve inhibition of A beta enzymes and prevention of GSK3 beta activity. These results suggest that gastrodin may be a potential treatment agent for AD.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Laura Carrero, Desiree Antequera, Ignacio Alcalde, Diego Megias, Lara Ordonez-Gutierrez, Cristina Gutierrez, Jesus Merayo-Lloves, Francisco Wandosell, Cristina Municio, Eva Carro
Summary: Alzheimer's disease, characterized by disrupted circadian rhythm and retinal pathology, is more prevalent in female individuals. The study found severe circadian rhythm disturbances and retinal pathological hallmarks in female APP/PS1 mice, along with A beta deposits in retinal layers. Reduced expression of aquaporins in the retinal tissue suggests that abnormal A beta transport contributes to retinal degeneration in the early stages of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jinman Liu, Xue Zuo, Mingjun Huang, Jiansong Fang, Weirong Li, Qing Shi, Qi Wang, Yong Liang
Summary: This study investigates the potential effects of Gomisin B on cognitive dysfunction in APP/PS1 transgenic mice and finds that it significantly improves cognitive function. The simultaneous administration of OST and Gomisin B shows enhanced therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Henrique Correia Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Talita Glaser, Milena da Silva Milanis, Christiane Gimenes, Deborah Suchecki, Ricardo Mario Arida, Henning Ulrich, Beatriz Monteiro Longo
Summary: The aim of this study was to investigate the effects of resistance exercise on preventing and recovering from AD-related neuropathological conditions in APP/PS1 mice. The results showed that 4 weeks of resistance exercise improved locomotor activity and memory in APP/PS1 mice, and reduced A beta plaques and systemic inflammation. These findings suggest that resistance exercise plays a role in alleviating AD symptoms and can be an effective complementary treatment for AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Jikun Du, Jierong Liu, Xiaoman Huang, Yuanhua Li, Daibo Song, Qin Li, Jiantao Lin, Baohong Li, Li Li
Summary: This study found that catalpol has neuroprotective effects in Alzheimer's disease (AD), improving cell toxicity, reducing apoptosis, ameliorating neuronal structural damage, improving cognitive deficits, and enhancing mitochondrial functions. Additionally, catalpol can inhibit the oligomerization and aggregation of amyloid beta (A beta) and regulate the expression of AKT, GSK3 beta, and BACE1.
NEUROTOXICITY RESEARCH
(2022)
Article
Neurosciences
Daiki Nakatsuka, Takaya Izumi, Tasuku Tsukamoto, Miki Oyama, Kohei Nishitomi, Yuichi Deguchi, Kazuki Niidome, Hidekuni Yamakawa, Hisanori Ito, Koichi Ogawa
Summary: Studies suggest that HDAC2 inhibition has disease-modifying effects in treating Alzheimer's disease (AD) and has the potential to slow disease progression. Knockdown of HDAC2 in transgenic mouse models can improve synaptic morphology and memory function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Immunology
Pu Wang, Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Yan Zhang, Hang Zhao, Zhan-You Wang
CELLULAR & MOLECULAR IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Yingbo Fu, Yu Mu, Hui Lei, Pu Wang, Xin Li, Qiao Leng, Li Han, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Neurosciences
Yin Li, Ze-Xu Li, Tan Jin, Zhan-You Wang, Pu Zhao
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Ni Zong, Shi-Xin Ma, Zhan-You Wang
JOURNAL OF CHEMICAL NEUROANATOMY
(2017)
Article
Biochemistry & Molecular Biology
Xiaoxu Bi, Pu Wang, Qingjuan Ma, Li Han, Xingbo Wang, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Biochemistry & Molecular Biology
Xiaoxu Bi, Li Han, Tiange Qu, Yu Mu, Peipei Guan, Xiaodan Qu, Zhanyou Wang, Xueshi Huang
Article
Neurosciences
Chuang Guo, Zhao-Hui Yang, Shuai Zhang, Rui Chai, Han Xue, Yan-Hui Zhang, Jia-Yi Li, Zhan-You Wang
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Oncology
Yue Wang, Pei-Pei Guan, Xin Yu, Yan-Su Guo, Ying-Jie Zhang, Zhan-You Wang, Pu Wang
Article
Oncology
Shuai Zhang, Rui Chai, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Shuang-Feng Xu, Yan-Hui Zhang, Zhan-You Wang, Chuang Guo
Article
Geriatrics & Gerontology
Dan-Dan Li, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Geriatrics & Gerontology
Zhuo Wang, Ya-Hong Zhang, Chuang Guo, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Na-Na Liu, Rui-Fang Guo, Tian Lan, Wei Zhang, Zhan-You Wang, Pu Zhao
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Guo
Article
Engineering, Biomedical
Jing-Wen Guo, Pei-Pei Guan, Wei-Yan Ding, Si-Ling Wang, Xue-Shi Huang, Zhan-You Wang, Pu Wang
Article
Chemistry, Medicinal
Qing-juan Ma, Li Han, Yu Mu, Pei-pei Guan, Hui Lei, Zhan-you Wang, Xue-shi Huang
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)
Article
Cell Biology
Pu Wang, Zhan-You Wang
AGEING RESEARCH REVIEWS
(2017)