Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

(2021) Afzal Misrani et al.   Frontiers in Aging Neuroscience

Efficacy of Δ9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice

(2021) Prakash Nidadavolu et al.   Frontiers in Aging Neuroscience

The Essential Medicinal Chemistry of Cannabidiol (CBD)

(2020) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acute Cannabinoids Produce Robust Anxiety-Like and Locomotor Effects in Mice, but Long-Term Consequences Are Age- and Sex-Dependent

(2019) Chelsea R. Kasten et al.   Frontiers in Behavioral Neuroscience

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

(2018) Inhae Kang et al.   FEBS LETTERS

Reversal of age-related cognitive impairments in mice by an extremely low dose of tetrahydrocannabinol

(2018) Yosef Sarne et al.   NEUROBIOLOGY OF AGING

Amyloid-β Toxicity and Tau Hyperphosphorylation are Linked Via RCAN1 in Alzheimer's Disease

(2018) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

Optimized Protocol for Amyloid-β Extraction from the Brain

(2018) María Izco et al.   JOURNAL OF ALZHEIMERS DISEASE

Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

(2018) Maria J. Casarejos et al.   JOURNAL OF ALZHEIMERS DISEASE

The Potential Therapeutic Effects of THC on Alzheimer's Disease

(2018) Chuanhai Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-β Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

(2018) Stina Tucker et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Cannabidiol Treatment Prevents the Development of Social Recognition Memory Deficits in Alzheimer's Disease Transgenic Mice

(2018) David Cheng et al.   JOURNAL OF ALZHEIMERS DISEASE

MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

(2018) Tommy L. Lewis et al.   Nature Communications

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice

(2017) Andras Bilkei-Gorzo et al.   NATURE MEDICINE

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains

(2017) Jong Whi Kim et al.   NEURAL PLASTICITY

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

(2017) Georgia Watt et al.   Frontiers in Pharmacology

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

(2017) Ambika Krishnankutty et al.   Scientific Reports

Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao−/−) mice

(2016) David Pritchett et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model

(2016) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

d-amino acid oxidase knockout (Dao−/−) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption

(2015) David Pritchett et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Tetrahydrocannabinol Induces Brain Mitochondrial Respiratory Chain Dysfunction and Increases Oxidative Stress: A Potential Mechanism Involved in Cannabis-Related Stroke

(2015) Valérie Wolff et al.   Biomed Research International

Assessing Spatial Learning and Memory in Rodents

(2014) C. V. Vorhees et al.   ILAR JOURNAL

Early phytocannabinoid chemistry to endocannabinoids and beyond

(2014) Raphael Mechoulam et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro

(2013) Emelie Janefjord et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+Cells Through PPARγ Involvement

(2013) Caterina Scuderi et al.   PHYTOTHERAPY RESEARCH

mtDNA makes a U-turn for the mitochondrial nucleoid

(2013) Christian Kukat et al.   TRENDS IN CELL BIOLOGY

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

(2012) Benjamin S. Harvey et al.   NEUROTOXICOLOGY

Synapses and Dendritic Spines as Pathogenic Targets in Alzheimer’s Disease

(2012) Wendou Yu et al.   NEURAL PLASTICITY

An Evidence-Based Review of Acute and Long-Term Effects of Cannabis Use on Executive Cognitive Functions

(2011) Rebecca D. Crean et al.   Journal of Addiction Medicine

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

(2011) Michael Ewers et al.   TRENDS IN NEUROSCIENCES

Glycogen synthase kinase-3β, or a link between amyloid and tau pathology?

(2010) D. Muyllaert et al.   GENES BRAIN AND BEHAVIOR

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Dementia incidence continues to increase with age in the oldest old: The 90+ study

(2009) María M. Corrada et al.   ANNALS OF NEUROLOGY

The role of glycogen synthase kinase 3 in the early stages of Alzheimers’ disease

(2008) Félix Hernández et al.   FEBS LETTERS

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

(2007) G Esposito et al.   BRITISH JOURNAL OF PHARMACOLOGY