Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases

Hyaluronic acid for anticancer drug and nucleic acid delivery

(2016) Franco Dosio et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular mechanism of prion-like tau-induced neurodegeneration

(2016) Alejandra D. Alonso et al.   Alzheimers & Dementia

Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165

(2016) Dong-Kwon Lim et al.   BIOMATERIALS

Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss

(2016) J. Di et al.   Scientific Reports

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

(2016) Marianna Karina Gorsky et al.   Scientific Reports

Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis

(2015) Peadar Rooney et al.   Acta Biomaterialia

Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD

(2015) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Hyaluronic Acid Based Hydrogels Attenuate Inflammatory Receptors and Neurotrophins in Interleukin-1β Induced Inflammation Model of Nucleus Pulposus Cells

(2015) Isma Liza Mohd Isa et al.   BIOMACROMOLECULES

Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology

(2015) Katharina Stratmann et al.   BRAIN PATHOLOGY

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Targeting tau acetylation attenuates neurodegeneration

(2015) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Tau as the Converging Protein between Chronic Stress and Alzheimer's Disease Synaptic Pathology

(2015) Ioannis Sotiropoulos et al.   Neurodegenerative Diseases

High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration

(2015) Jeanna M. Wheeler et al.   Acta Neuropathologica Communications

Hyaluronan Deficiency Due to Has3 Knock-Out Causes Altered Neuronal Activity and Seizures via Reduction in Brain Extracellular Space

(2014) A. M. Arranz et al.   JOURNAL OF NEUROSCIENCE

Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease

(2014) Uwe Ueberham et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice

(2014) Tomohiro Onishi et al.   NEUROSCIENCE RESEARCH

Immunostimulatory and antiangiogenic activities of low molecular weight hyaluronic acid

(2013) Chunlin Ke et al.   FOOD AND CHEMICAL TOXICOLOGY

Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3

(2013) Kirsi Rilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation

(2013) M. Geissler et al.   JOURNAL OF NEUROSCIENCE

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Very long-term memories may be stored in the pattern of holes in the perineuronal net

(2013) R. Y. Tsien   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia

(2012) Henrietta M. Nielsen et al.   Current Alzheimer Research

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Reduction of intercellular adhesion molecule 1 may play a role in anti-inflammatory effect of hyaluronic acid in a rat model of severe non-bacterial cystitis

(2012) Yuan Shao et al.   WORLD JOURNAL OF UROLOGY

Involvement of Perineuronal and Perisynaptic Extracellular Matrix in Alzheimer's Disease Neuropathology

(2011) Markus Morawski et al.   BRAIN PATHOLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: Amyloidogenesis and therapeutic strategies-A review

(2010) Toshio Ariga et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels

(2010) Gaga Kochlamazashvili et al.   NEURON

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

(2010) M. Morawski et al.   NEUROSCIENCE

β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration

(2010) Mirsada Čaušević et al.   NEUROSCIENCE LETTERS

Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

(2009) Ilona B. Bruinsma et al.   ACTA NEUROPATHOLOGICA

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Kinetic Analysis of Amyloid Formation in the Presence of Heparan Sulfate

(2009) Neda Motamedi-Shad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Extracellular matrix in plasticity and epileptogenesis

(2009) Alexander Dityatev et al.   Neuron Glia Biology

Sulfated Polysaccharides Promote the Assembly of Amyloid β1–42 Peptide into Stable Fibrils of Reduced Cytotoxicity

(2008) Ramona Bravo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrospinal fluid levels of tau phosphorylated at threonine 181 in patients with Alzheimer’s disease and vascular dementia

(2008) Sabrina Ravaglia et al.   NEUROLOGICAL SCIENCES