SUMO and Parkinson’s Disease

Neuronal Intranuclear Inclusion Disease Presenting as Juvenile Parkinsonism

(2014) Katie M. Wiltshire et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

(2013) Grit Taschenberger et al.   ANNALS OF NEUROLOGY

Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis

(2013) R. Li et al.   CANCER RESEARCH

UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131

(2013) Yohan Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detecting endogenous SUMO targets in mammalian cells and tissues

(2013) Janina Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease

(2013) J. Weetman et al.   NEUROSCIENCE LETTERS

CASK and CaMKII function in the mushroom body α′/β′ neurons during Drosophila memory formation

(2013) Bilal R. Malik et al.   Frontiers in Neural Circuits

Drosophila DJ-1 Decreases Neural Sensitivity to Stress by Negatively Regulating Daxx-Like Protein through dFOXO

(2013) Soojin Hwang et al.   PLoS Genetics

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection

(2012) Qiang Zhang et al.   BIOCHEMICAL JOURNAL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode

(2012) Dorothea Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SUMO ligase PIAS1 regulates UV-induced apoptosis by recruiting Daxx to SUMOylated foci

(2012) R. Sudharsan et al.   JOURNAL OF CELL SCIENCE

An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks

(2012) Rebecca Ullmann et al.   MOLECULAR CELL

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

(2012) Laureano de la Vega et al.   MOLECULAR CELL

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

Neurodegeneration in Parkinson disease: Moving Lewy bodies out of focus

(2012) W. J. Schulz-Schaeffer   NEUROLOGY

SUMO-1 is Associated with a Subset of Lysosomes in Glial Protein Aggregate Diseases

(2012) Mathew B. Wong et al.   NEUROTOXICITY RESEARCH

Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease

(2012) Fumiaki Mori et al.   PATHOLOGY INTERNATIONAL

In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice

(2012) M. Tirard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling

(2012) Jung-Min Kim et al.   Nature Communications

Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1

(2012) Derya R. Shimshek et al.   Scientific Reports

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation

(2011) Kristine M. Wadosky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation

(2011) Yohan Oh et al.   BRAIN RESEARCH

Identification of two independent SUMO-interacting motifs in Daxx: Evolutionary conservation from Drosophila to humans and their biochemical functions

(2011) Aleixo Santiago et al.   CELL CYCLE

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

(2011) Maren H. Stindt et al.   CELL CYCLE

The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition

(2011) S Vilotti et al.   CELL DEATH AND DIFFERENTIATION

All the Little Pieces

(2011) Makhosazane Zungu et al.   CIRCULATION JOURNAL

Characterizing the N- and C-terminal Small Ubiquitin-like Modifier (SUMO)-interacting Motifs of the Scaffold Protein DAXX

(2011) Eric Escobar-Cabrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses

(2011) Qi Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competition between Sumoylation and Ubiquitination of Serine Hydroxymethyltransferase 1 Determines Its Nuclear Localization and Its Accumulation in the Nucleus

(2011) Donald D. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation

(2011) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylation inhibits α-synuclein aggregation and toxicity

(2011) Petranka Krumova et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

(2011) Yong Man Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Structural and Functional Roles of Daxx SIM Phosphorylation in SUMO Paralog-Selective Binding and Apoptosis Modulation

(2011) Che-Chang Chang et al.   MOLECULAR CELL

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations

(2011) Peter Elfferich et al.   NEUROGENETICS

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor γ in C2C12 myotubes

(2010) Sung Soo Chung et al.   BIOCHEMICAL JOURNAL

Acetylation of p65 at lysine 314 is important for late NF-κB-dependent gene expression

(2010) Karin M Rothgiesser et al.   BMC GENOMICS

Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism?

(2010) Cristine Alves da Costa et al.   CELLULAR SIGNALLING

Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage

(2010) Jue Chen et al.   HUMAN MOLECULAR GENETICS

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson Disease-associated DJ-1 Is Required for the Expression of the Glial Cell Line-derived Neurotrophic Factor Receptor RET in Human Neuroblastoma Cells

(2010) Rossana Foti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB

(2010) R. Sean McNally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity

(2010) Sebastian Deeg et al.   JOURNAL OF CELL BIOLOGY

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

(2010) Sören Mai et al.   JOURNAL OF CELL SCIENCE

Protein degradation, aggregation, and misfolding

(2010) Ana Maria Cuervo et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

SUMO E3 ligase activity of TRIM proteins

(2010) Y Chu et al.   ONCOGENE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

(2009) Claudia Figueroa-Romero et al.   FASEB JOURNAL

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

SUMOylation of Human Peroxisome Proliferator-activated Receptor α Inhibits Its Trans-activity through the Recruitment of the Nuclear Corepressor NCoR

(2009) Benoit Pourcet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential DJ-1 gene expression in Parkinson's disease

(2009) Ravindran Kumaran et al.   NEUROBIOLOGY OF DISEASE

Modelling Parkinson’s Disease in Drosophila

(2009) José A. Botella et al.   NEUROMOLECULAR MEDICINE

Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1

(2009) Anna Sandebring et al.   PLoS One

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture

(2008) Dean L. Pountney et al.   ACTA NEUROPATHOLOGICA

Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations

(2008) S Zucchelli et al.   CELL DEATH AND DIFFERENTIATION

Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1α: regulation by SUMOylation and oxidation

(2008) Nan Zhong et al.   HUMAN MOLECULAR GENETICS

Modification ofDrosophilap53 by SUMO Modulates Its Transactivation and Pro-apoptotic Functions

(2008) Federico Mauri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis

(2008) Hsu-Wen Chao et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY

Direct Binding with Histone Deacetylase 6 Mediates the Reversible Recruitment of Parkin to the Centrosome

(2008) Q. Jiang et al.   JOURNAL OF NEUROSCIENCE

Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25

(2008) Erik Meulmeester et al.   MOLECULAR CELL

Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease

(2008) Katrin Beyer et al.   NEUROGENETICS

DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age

(2008) Steven J. Mullett et al.   NEUROPATHOLOGY

The kinase domain of mitochondrial PINK1 faces the cytoplasm

(2008) C. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma

(2007) Ben Davidson et al.   HUMAN PATHOLOGY

Daxx contains two nuclear localization signals and interacts with importin α3

(2007) Percy Luk Yeung et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons

(2007) Francesco Errico et al.   MOLECULAR AND CELLULAR NEUROSCIENCE