Article
Multidisciplinary Sciences
Eva L. Morozko, Charlene Smith-Geater, Alejandro Mas Monteys, Subrata Pradhan, Ryan G. Lim, Peter Langfelder, Marketta Kachemov, Austin Hill, Jennifer T. Stocksdale, Pieter R. Cullis, Jie Wu, Joseph Ochaba, Ricardo Miramontes, Anirban Chakraborty, Tapas K. Hazra, Alice Lau, Sophie St-Cyr, Iliana Orellana, Lexi Kopan, Keona Q. Wang, Sylvia Yeung, Blair R. Leavitt, Jack C. Reidling, X. William Yang, Joan S. Steffan, Beverly L. Davidson, Partha S. Sarkar, Leslie M. Thompson
Summary: This study reveals the involvement of PIAS1 in DNA damage repair pathways and its connection with transcriptional modulation in neurodegenerative diseases. Knockdown of PIAS1 in HD mice normalizes transcriptional dysregulation and DNA damage repair mechanisms, impacting genomic integrity in neurons. The findings highlight the role of SUMO modifying machinery in DNA damage repair responses and transcriptional modulation in the context of neurodegenerative disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ayan Chanda, Yoshiho Ikeuchi, Kunal Karve, Anusi Sarkar, Amrita Singh Chandhoke, Lili Deng, Azad Bonni, Shirin Bonni
Summary: Studies show that SUMO E3 ligases PIAS1 and TIF1γ collaborate to promote the SUMOylation of SnoN, suppressing EMT in breast cell-derived tissue organoids. These E3 ligases act in an interdependent manner in the regulation process.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Microbiology
Guangwen Wang, Yuhui Zhao, Yuan Zhou, Li Jiang, Libin Liang, Fandi Kong, Ya Yan, Xuyuan Wang, Yihan Wang, Xia Wen, Xianying Zeng, Guobin Tian, Guohua Deng, Jianzhong Shi, Liling Liu, Hualan Chen, Chengjun Li
Summary: The protein inhibitor of activated STAT 1 (PIAS1) interacts with nucleoprotein (NP), polymerase basic protein 1 (PB1), and polymerase basic protein 2 (PB2) of influenza A virus (IAV). PIAS1 suppresses IAV replication by inhibiting the activity of the viral RNP complex and catalyzing robust SUMOylation of PB2.
Article
Multidisciplinary Sciences
Liangqian Huang, Trisha Agrawal, Guixin Zhu, Sixiang Yu, Liming Tao, JiaBei Lin, Ronen Marmorstein, James Shorter, Xiaolu Yang
Summary: Protein quality control systems are crucial for cellular function and organismal health. Recent studies have shown that polyD/E proteins, such as DAXX, ANP32A, and SET, may constitute a multifunctional protein quality control system that operates via a distinctive mechanism without relying on ATP.
Article
Biochemistry & Molecular Biology
Zhaosu Chen, Yunpeng Zhang, Qingqing Guan, Huifang Zhang, Jing Luo, Jialun Li, Wei Wei, Xiang Xu, Lujian Liao, Jiemin Wong, Jiwen Li
Summary: The study reveals that SUMOylation machinery components are primarily associated with the nuclear matrix rather than chromatin. PIAS1 directly interacts with histone proteins and plays a role in regulating transcription and other chromatin-related processes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nathaniel J. Robinson, Masaru Miyagi, Jessica A. Scarborough, Jacob G. Scott, Derek J. Taylor, William P. Schiemann
Summary: Telomere-associated protein SLX4IP regulates telomere proteome composition by recruiting and activating E3 SUMO ligase PIAS1 to the SLX4 complex. This activation leads to the SUMOylation of telomere-binding protein RAP1, disrupting its interaction with TRF2 and promoting its nucleocytoplasmic shuttling, ultimately activating NF-kappa B signaling and inducing Jagged-1 expression to facilitate ALT and potentially targeting ALT-driven cancers therapeutically.
Article
Fisheries
Kai Liu, Zhaoxiang Sun, Chun Yang, Li Jan Lo, Jun Chen
Summary: The XPC protein is involved in recognizing DNA damage and initiating nucleotide excision repair. A zebrafish xpc knockout mutant was generated and found to have increased sensitivity to UV irradiation, leading to higher levels of DNA damage and apoptosis. In addition to its role in DNA repair, XPC also plays a role in other cellular processes.
Article
Polymer Science
Tomislav Grzan, Lucianna Grieco, Vjekoslav Zivkovic, Goran Mihulja
Summary: Various surface modification techniques have been developed to enhance the wetting, adhesion, and printing properties of synthetic polymer surfaces by adding functional groups. UV irradiation has shown potential as a suitable method for surface modification of polymers, which can also improve the bonding properties of wood-glue systems. This study aimed to assess the feasibility of UV irradiation as a pretreatment for wood surfaces before gluing and evaluate the properties of wooden glued joints. The research found that UV irradiation improved the bonding properties of differently machined wood.
Article
Biophysics
Renata Guimaraes de Sa, Tatiane Moraes Arantes, Erenilda Ferreira de Macedo, Luisa Molina Dona, Jeniffer C. F. Pereira, Carolina Ramos Hurtado, R. Jose Varghese, Oluwatobi Samuel Oluwafemi, Dayane Batista Tada
Summary: This study focused on the evaluation of the photoprotective activity and cytotoxicity of zirconia nanoparticles. The results showed that ZrO2 NPs exhibited low cytotoxicity and provided effective protection under UV irradiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Environmental
Bryan Liu, Lauren Mullen, Emma M. Payne, Karl G. Linden
Summary: Krypton chloride (KrCl*) excimer ultraviolet (UV) light may offer advantages over conventional low-pressure (LP) UV for contaminant degradation. The authors investigated the direct and indirect photolysis as well as UV/hydrogen peroxide-driven advanced oxidation (AOP) of two chemical contaminants in different water samples using KrCl* and 254nm, 222nm UV sources. The results showed that the 222nm excimer lamps significantly improved the degradation of contaminants compared to the conventional 254nm LPUV. Rating: 8/10.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Minggu Zhang, Na Liu, Lei Hou, Chao Li, Chengliang Li
Summary: Both biodegradable microplastics (PBAT and PLA) and non-degradable microplastics (PP) were studied for their surface modification and adsorption behaviors of CPF after one month of UV irradiation. PBAT showed the highest adsorption capacity while PLA exhibited the fastest adsorption rate. UV irradiation reduced the adsorption capacities of PLA and PP but enhanced the adsorption capacities of PBAT. Specific surface area was found to be the main factor affecting the adsorption capacities of PP and PLA after UV irradiation. These findings deepen the understanding of the interaction between CPF and microplastics, and provide a theoretical basis for evaluating the ecological risk of microplastics in water.
MARINE POLLUTION BULLETIN
(2023)
Article
Cell Biology
Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng Li
Summary: The protein PIAS1 plays a key role in regulating stress-induced lens pathogenesis by enhancing p53 transcription activity to promote Bax upregulation, thus facilitating stress-induced apoptosis in lens epithelial cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Zlata V. Ogneva, Vlada V. Volkonskaia, Alexandra S. Dubrovina, Andrey R. Suprun, Olga A. Aleynova, Konstantin V. Kiselev
Summary: The study found that the application of trans-resveratrol and trans-piceid can enhance Arabidopsis thaliana plants' tolerance to UV-B, increasing leaf survival rates. This improvement in tolerance is more effective than using precursors but slightly less effective than using a UV-B absorber. Furthermore, trans-resveratrol also increased the expression of antioxidant and stress-inducible genes.
Article
Engineering, Environmental
Yinqiao Zhang, Juhong Zhan, Bin Wang, Jun Huang, Shubo Deng, Gang Yu, Sridhar Komarneni, Yujue Wang
Summary: This research evaluated the combination of UV irradiation and electrochemical processes for micropollutant abatement in water treatment, finding that the divided E-UV/Cl-2/H2O2 process was more effective and energy-efficient for removing micropollutants. The study highlights the potential synergistic effects of combining UV and electrochemical methods in different configurations for decentralized water treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Lu Chen, Hongchao Li, Jieshu Qian
Summary: The degradation of roxarsone (ROX) via UV-based advanced oxidation processes (AOPs) was investigated, with UV/PDS being the most effective in removing ROX and UV/H2O2 being the most effective in reducing total organic carbon (TOC). The degradation of ROX follows a pseudo-first-order kinetics model, with a significant enhancement observed at pH 11.0 in UV/PMS process.
JOURNAL OF HAZARDOUS MATERIALS
(2021)