Article
Clinical Neurology
Yan Lin, Jiayin Wang, Hong Ren, Xiaotian Ma, Wei Wang, Ying Zhao, Zhihong Xu, Shuangwu Liu, Wenqing Wang, Xuebi Xu, Bin Wang, Dandan Zhao, Dongdong Wang, Wei Li, Fuchen Liu, Yuying Zhao, Jianqiang Lu, Chuanzhu Yan, Kunqian Ji
Summary: This study provides a comprehensive profile of MiMy through a large patient cohort, elucidating its unique clinical, genetic, and pathological features. These findings offer significant insights into the diagnostic and therapeutic management of MiMy, ultimately aiming to improve patient outcomes and enhance the quality of life.
JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Thomas Klopstock, Claudia Priglinger, Ali Yilmaz, Cornelia Kornblum, Felix Distelmaier, Holger Prokisch
Summary: Mitochondrial disorders are highly heterogeneous with a variety of clinical manifestations. A correct diagnosis is crucial for genetic counseling and personalized treatment.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Piervito Lopriore, Fabio Gomes, Vincenzo Montano, Gabriele Siciliano, Michelangelo Mancuso
Summary: Primary mitochondrial diseases are relatively common inborn errors of energy metabolism that typically affect tissues with high energy requirements, including the brain. Epilepsy, affecting >1% of the worldwide population, can be a presenting feature of mitochondrial diseases and poses challenges in treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hiroaki Mori, Yuta Yoshino, Jun-ichi Iga, Shinichiro Ochi, Yu Funahashi, Kiyohiro Yamazaki, Hiroshi Kumon, Yuki Ozaki, Shu-ichi Ueno
Summary: In this study, the gene expression levels in the brain of 3xTg-AD model mice were explored to understand the molecular pathological changes of Alzheimer's disease (AD) from early to late stages. The study found changes in immune response and GABAergic neurotransmission in the brain of the mice from early to late stages of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Genetics & Heredity
Nathalie Schneider, Ellen Reed, Faddy Kamel, Enrico Ferrari, Mikhail Soloviev
Summary: This study predicts molecular biomarkers for breast cancer using a data mining approach. It explores the relationship between subtype-specific and pan-cancer biomarkers and suggests potential extracellular markers for early non-invasive detection of the disease.
Article
Multidisciplinary Sciences
Charley Xia, Sarah J. Pickett, David C. M. Liewald, Alexander Weiss, Gavin Hudson, W. David Hill
Summary: Neuroticism is a heritable trait influenced by mitochondrial DNA, and associations between mitochondrial haplogroups and genetic variation have been found. The study reveals the links between neuroticism and various facets, as well as the relationships between mitochondrial genetic variation and overall health.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tengfei Luo, Kuokuo Li, Zhengbao Ling, Guihu Zhao, Bin Li, Zheng Wang, Xiaomeng Wang, Ying Han, Lu Xia, Yi Zhang, Qiao Zhou, Zhenghuan Fang, Yijing Wang, Qian Chen, Xun Zhou, Hongxu Pan, Yuwen Zhao, Yige Wang, Lijie Dong, Yuanfeng Huang, Zhengmao Hu, Qian Pan, Kun Xia, Jinchen Li
Summary: The study identified an association between de novo mutations in folate-related genes and the risk of developmental disorders. By analyzing genetic data, 96 candidate disease-associated genes were prioritized, playing crucial roles in development. The findings contribute to the discovery of biomarkers and therapeutic targets for developmental disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Fisheries
Tieying Yu, Junhao Ning, Min Chen, Yuan Wang, Guilong Liu, Quanchao Wang, Xin Xu, Chunde Wang, Xia Lu
Summary: This study investigates the mechanism of hybrid sterility in hermaphroditic Argopecten scallops by examining mutations in mitochondrial genes and the expression of nuclear genes. The results show that energy deficiency may be the immediate cause of sterility in F1 hybrid scallops. Abnormal interaction between mitochondrial and nuclear genes may contribute to hybrid sterility through multiple pathways. This study provides important information for understanding hybrid sterility in hermaphroditic animals and can benefit hybrid breeding programs.
AQUACULTURE REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Masamichi Ikawa, Hidehiko Okazawa, Makoto Yoneda
Summary: Molecular imaging techniques have made significant advances in studying mitochondrial diseases and neurodegenerative disorders, revealing metabolic changes and increased oxidative stress in patients with these conditions. The level of oxidative stress in patients with neurodegenerative diseases is closely associated with clinical severity.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Review
Clinical Neurology
Renae J. Stefanetti, Yi Shiau Ng, Linda Errington, Alasdair P. Blain, Robert McFarland, Grainne S. Gorman
Summary: Managing stroke-like episodes in patients with mitochondrial disease is challenging, and a systematic review on the use of L-arginine in this context revealed no demonstrable clinical benefit in either acute or prophylactic treatment. More robust controlled trials are needed to assess the efficacy and safety profile of L-arginine.
Review
Cell Biology
Elly I. Lewerissa, Nael Nadif Kasri, Katrin Linda
Summary: Autophagy is a crucial metabolic process for maintaining cellular homeostasis and survival. Recent studies have shown the importance of autophagy in brain function, particularly in neuronal development and functioning. Mutations in autophagy-related genes as well as genes involved in epigenetic regulation have been linked to neurodevelopmental disorders (NDDs). This suggests that aberrant autophagic regulation may contribute to nervous system impairments in NDDs with disturbed epigenetic regulation.
Article
Biochemical Research Methods
Pontus Eriksson, Nour-al-dain Marzouka, Gottfrid Sjodahl, Carina Bernardo, Fredrik Liedberg, Mattias Hoglund
Summary: In this study, we evaluated the behavior of gene-pair-based single sample predictors (SSPs) in gene expression-based multiclass prediction tasks. We found that these methods showed excellent performance, with high accuracy and informative prediction scores, in many expression-based classification tasks. However, the compatibility of gene-pair-based predictors with new datasets still needs to be verified.
Editorial Material
Medicine, Research & Experimental
Marjan Gucek, Michael N. Sack
Summary: By analyzing blood and urine samples from patients with MELAS syndrome, researchers have identified proteins and metabolites related to NADH-reductive stress, which may serve as important biomarkers for future management of the disease. These circulating biomarkers have intriguing clinical potential that could implicate disease pathophysiology and guide therapeutic efficacy monitoring.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Genetics & Heredity
Allison Hanaford, Simon C. Johnson
Summary: Genetic mitochondrial diseases pose a significant challenge to human health, and recent evidence suggests that the immune system plays a key role in the pathogenesis of at least some forms of these diseases.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Geriatrics & Gerontology
Foteini Aktypi, Nikoletta Papaevgeniou, Konstantinos Voutetakis, Aristotelis Chatziioannou, Tilman Grune, Niki Chondrogianni
Summary: Research has shown that analyzing genes affected by age through molecular pathways can help identify potential ageing regulators. By constructing a network of molecular interactions, 110 candidate genes were identified, some of which are known ageing regulators, while others include candidates that have not been linked to ageing before.
Article
Biology
Kara L. McKinley, Nico Stuurman, Loic A. Royer, Christoph Schartner, David Castillo-Azofeifa, Markus Delling, Ophir D. Klein, Ronald D. Vale
Article
Computer Science, Software Engineering
Zana Vosough, Marius Hograefer, Loic A. Royer, Rainer Groh, Hans-Joerg Schulz
COMPUTERS & GRAPHICS-UK
(2018)
Article
Biochemistry & Molecular Biology
Katie McDole, Leo Guignard, Fernando Amat, Andrew Berger, Gregoire Malandain, Loic A. Royer, Srinivas C. Turaga, Kristin Branson, Philipp J. Keller
Article
Biochemical Research Methods
Martin Weigert, Uwe Schmidt, Tobias Boothe, Andreas Mueller, Alexandr Dibrov, Akanksha Jain, Benjamin Wilhelm, Deborah Schmidt, Coleman Broaddus, Sian Culley, Mauricio Rocha-Martins, Fabian Segovia-Miranda, Caren Norden, Ricardo Henriques, Marino Zerial, Michele Solimena, Jochen Rink, Pavel Tomancak, Loic Royer, Florian Jug, Eugene W. Myers
Article
Biochemical Research Methods
Chinmay Belthangady, Loic A. Royer
Letter
Biochemical Research Methods
Robert Haase, Loic A. Royer, Peter Steinbach, Deborah Schmidt, Alexandr Dibrov, Uwe Schmidt, Martin Weigert, Nicola Maghelli, Pavel Tomancak, Florian Jug, Eugene W. Myers
Letter
Biochemical Research Methods
Henry Pinkard, Nico Stuurman, Ivan E. Ivanov, Nicholas M. Anthony, Wei Ouyang, Bin Li, Bin Yang, Mark A. Tsuchida, Bryant Chhun, Grace Zhang, Ryan Mei, Michael Anderson, Douglas P. Shepherd, Ian Hunt-Isaak, Raymond L. Dunn, Wiebke Jahr, SaulKato, Loic A. Royer, Jay R. Thiagarajah, Kevin W. Eliceiri, Emma Lundberg, Shalin B. Mehta, Laura Waller
Article
Cell Biology
Zehra Ali-Murthy, Richard D. Fetter, Wanpeng Wang, Bin Yang, Loic A. Royer, Thomas B. Kornberg
Summary: During Drosophila oocyte development, germline nurse cells pass products to the oocyte through intercellular bridges. At an early stage, two nurse cells fuse with the oocyte and extrude their nuclei, paving the way for subsequent development. Failure to eliminate nurse cell nuclei at the right stage results in abnormal morphology in the developing oocyte.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lucas von Chamier, Romain F. Laine, Johanna Jukkala, Christoph Spahn, Daniel Krentzel, Elias Nehme, Martina Lerche, Sara Hernandez-Perez, Pieta K. Mattila, Eleni Karinou, Seamus Holden, Ahmet Can Solak, Alexander Krull, Tim-Oliver Buchholz, Martin L. Jones, Loic A. Royer, Christophe Leterrier, Yoav Shechtman, Florian Jug, Mike Heilemann, Guillaume Jacquemet, Ricardo Henriques
Summary: ZeroCostDL4Mic is an entry-level platform that simplifies access to deep learning by leveraging the free, cloud-based computational resources of Google Colab. Researchers can train and apply key deep learning networks for various microscopy tasks without coding expertise. The platform provides quantitative tools for model evaluation and optimization.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Merlin Lange, AhmetCan Solak, Shruthi Vijay Kumar, Hirofumi Kobayashi, Bin Yang, Loic Alain Royer
Summary: ZAF and its advanced version ZAF+ are fully automatic feeding systems that provide standardized food distribution for different aquatic facilities, being cost-efficient, easy to build, and adaptable to any laboratory environment.
Article
Biochemical Research Methods
Bin Yang, Merlin Lange, Alfred Millett-Sikking, Xiang Zhao, Jordao Bragantini, Shruthi VijayKumar, Mason Kamb, Rafael Gomez-Sjoberg, Ahmet Can Solak, Wanpeng Wang, Hirofumi Kobayashi, Matthew N. McCarroll, Lachlan W. Whitehead, Reto P. Fiolka, Thomas B. Kornberg, Andrew G. York, Loic A. Royer
Summary: The DaXi single-objective light-sheet microscope is capable of fast, high-quality imaging of large volumes, with advanced features such as remote focusing, fast volumetric imaging, and multi-view imaging. It achieves high resolution within the imaging volume and can image multiple samples simultaneously, demonstrating outstanding speed, resolution, and versatility.
Article
Multidisciplinary Sciences
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, Andre C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y. S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gomez-Sjoberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Summary: This article introduces a method that uses various techniques to systematically map the localization and interactions of human proteins, and discovers the rich functional information contained in protein localization patterns.
Article
Biochemical Research Methods
Hirofumi Kobayashi, Keith C. Cheveralls, Manuel D. Leonetti, Loic A. Royer
Summary: Cytoself is a self-supervised deep learning-based approach that accurately predicts and clusters protein localization from fluorescence images, providing insights into the diversity and complexity of cellular architecture.
Article
Microbiology
Weili Kong, Mauricio Montano, Michael J. Corley, Ekram Helmy, Hirofumi Kobayashi, Martin Kinisu, Rahul Suryawanshi, Xiaoyu Luo, Loic A. Royer, Nadia R. Roan, Melanie Ott, Lishomwa C. Ndhlovu, Warner C. Greene
Summary: SARS-CoV-2 primarily targets the lung, but can also damage other organs, including the brain. This study found that astrocytes are easily infected by the virus, with neuropilin-1 serving as the principal receptor for cell entry. Infection leads to changes in gene expression related to immune signaling and inflammation, creating a microenvironment in the central nervous system that disrupts normal neuron function and promotes neuronal cell death.
Editorial Material
Biochemical Research Methods
Loic A. Royer