T cells out of control—impaired immune regulation in the inflamed joint

Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells

(2014) G. H. Stummvoll et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

(2014) L. E. Clough et al.   JOURNAL OF IMMUNOLOGY

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression

(2014) S. K. Chauhan et al.   JOURNAL OF IMMUNOLOGY

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

(2012) Veronica Santarlasci et al.   IMMUNITY

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

Characterization of Effector Memory CD8+ T Cells in the Synovial Fluid of Rheumatoid Arthritis

(2012) Bon-A Cho et al.   JOURNAL OF CLINICAL IMMUNOLOGY

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells

(2012) K. Poppensieker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired suppression of synovial fluid CD4+CD25− T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells

(2011) Susanne Haufe et al.   ARTHRITIS AND RHEUMATISM

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

(2011) Lorenzo Cosmi et al.   ARTHRITIS AND RHEUMATISM

The response of T cells to interleukin-6 is differentially regulated by the microenvironment of the rheumatoid synovial fluid and tissue

(2011) Ester Hidalgo et al.   ARTHRITIS AND RHEUMATISM

Anti-TNFα discontinuation in rheumatoid and psoriatic arthritis: Is it possible after disease remission?

(2011) Maria Sole Chimenti et al.   AUTOIMMUNITY REVIEWS

TH1, TH2, and TH17 cells instruct monocytes to differentiate into specialized dendritic cell subsets

(2011) M. N. Alonso et al.   BLOOD

Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways

(2011) K. D. Nguyen et al.   BLOOD

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

(2011) E. J. Wehrens et al.   BLOOD

The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function

(2011) Jessica Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model

(2011) Pushpa Pandiyan et al.   IMMUNITY

Foxp3+ Regulatory T Cells Promote T Helper 17 Cell Development In Vivo through Regulation of Interleukin-2

(2011) Yi Chen et al.   IMMUNITY

FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25− responder T cells, but not CD4+CD25+ regulatory T cells

(2011) Ann L. Jagger et al.   JOURNAL OF AUTOIMMUNITY

TRAIL Is Associated with Impaired Regulation of CD4+CD25− T Cells by Regulatory T Cells in Patients with Rheumatoid Arthritis

(2011) Hong Xiao et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Differentiation of Inflammatory Dendritic Cells Is Mediated by NF- B1-Dependent GM-CSF Production in CD4 T Cells

(2011) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Single-Cell Analysis of the Human T Regulatory Population Uncovers Functional Heterogeneity and Instability within FOXP3+ Cells

(2011) E. d'Hennezel et al.   JOURNAL OF IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression

(2010) Patricia J. Hunter et al.   ARTHRITIS AND RHEUMATISM

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF Activates a NF- B-Regulated Cellular Program in Human CD45RA- Regulatory T Cells that Modulates Their Suppressive Function

(2010) M. Nagar et al.   JOURNAL OF IMMUNOLOGY

Profiling of CD4+ T Cells with Epigenetic Immune Lineage Analysis

(2010) P. C. J. Janson et al.   JOURNAL OF IMMUNOLOGY

The yin and yang of regulatory T cells and inflammation in RA

(2010) Clare A. Notley et al.   Nature Reviews Rheumatology

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surveillance of Antigen-Presenting Cells by CD4+CD25+ Regulatory T Cells in Autoimmunity

(2009) Sébastien André et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17-producing human peripheral regulatory T cells retain suppressive function

(2009) G. Beriou et al.   BLOOD

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

(2009) David Bending et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Responder T Cells Regulate Human DR+ Effector Regulatory T Cell Activity via Granzyme B

(2009) C. W. Ashley et al.   JOURNAL OF IMMUNOLOGY

IL-17 Induces Monocyte Migration in Rheumatoid Arthritis

(2009) S. Shahrara et al.   JOURNAL OF IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Regulatory T cells as therapeutic targets in rheumatoid arthritis

(2009) Jonathan H. Esensten et al.   Nature Reviews Rheumatology

IL-17 as a future therapeutic target for rheumatoid arthritis

(2009) Wim B. van den Berg et al.   Nature Reviews Rheumatology

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

(2009) H. G. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of natural Foxp3+T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

(2009) Noriko Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α–producing antigen-presenting cells

(2008) Bing Yan et al.   ARTHRITIS AND RHEUMATISM

Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells

(2008) Véronique Parietti et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17–producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers

(2008) Kiran Nistala et al.   ARTHRITIS AND RHEUMATISM

Reduced CD4+,CD25− T cell sensitivity to the suppressive function of CD4+,CD25high,CD127−/lowregulatory T cells in patients with active systemic lupus erythematosus

(2008) Ram Kumar Chowdary Venigalla et al.   ARTHRITIS AND RHEUMATISM

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Increased resistance to CD4+CD25hiregulatory T cell-mediated suppression in patients with type 1 diabetes

(2008) J. M. Lawson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance

(2008) MI Vargas-Rojas et al.   LUPUS

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

(2008) A. M. D'Alise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution and clinical significance of blood dendritic cells in children with juvenile idiopathic arthritis

(2007) E Smolewska et al.   ANNALS OF THE RHEUMATIC DISEASES