Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
M. Amelie Jule, J. Kacie Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, L. Maria Taylor, Julie Ng, A. James Lederer, M. Siobhan Case, H. Margaret Chang, M. Ezra Cohen, Fatma Dedeoglu, M. Melissa Hazen, S. Jonathan Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, S. Mindy Lo, Esra Meidan, E. Jordan Roberts, F. Mary Beth Son, P. Robert Sundel, Y. Pui Lee, Talal Chatila, A. Peter Nigrovic, A. Lauren Henderson
Summary: Oligoarticular juvenile idiopathic arthritis (oligo JIA) is characterized by Th1 polarization, particularly prominent in CD4+ T cells, while not compromising the regulatory identity of Tregs. Single-cell RNA-Seq revealed heterogeneous effector and regulatory subpopulations in synovial fluid, including IFN-induced Tregs, peripheral helper T cells, and cytotoxic CD4+ T cells.
Article
Immunology
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko
Summary: This study found that isolating Tregs using a CD4(+)CD25(+)CD226(-) strategy leads to a population with increased purity, lineage stability, and suppressive capabilities, which may be beneficial for the treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Juan Zhou, Junyan Wang, Linlin Tao, Mingyue Liu, Xuemei Tang, Xiaoping Zhu
Summary: NKG2D plays a significant role in the interactions between CD4+ T cells and dendritic cells (DCs) in juvenile idiopathic arthritis (JIA) patients. The expression of NKG2D is higher in articular JIA and it regulates the differentiation of CD4+ T cells and the maturation of DCs, indirectly affecting immune responses.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Juan Zhou, Junyan Wang, Linlin Tao, Mingyue Liu, Xuemei Tang, Xiaoping Zhu
Summary: NKG2D plays a role in the interactions between CD4+ T cells and dendritic cells in juvenile idiopathic arthritis (JIA) patients. The expression of NKG2D on CD4+ T cells and MICA/MICB on dendritic cells are significantly higher in JIA patients compared to healthy controls. NKG2D directly regulates the differentiation of CD4+ T cells and indirectly affects the maturation of dendritic cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Immunology
Anna Vanni, Alessio Mazzoni, Roberto Semeraro, Manuela Capone, Patrick Maschmeyer, Giulia Lamacchia, Lorenzo Salvati, Alberto Carnasciali, Parham Farahvachi, Teresa Giani, Gabriele Simonini, Giovanni Filocamo, Micol Romano, Francesco Liotta, Mir-Farzin Mashreghi, Lorenzo Cosmi, Rolando Cimaz, Alberto Magi, Laura Maggi, Francesco Annunziato
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood, with T cells playing a key role in its pathogenesis. The expression of PD-1 on CD4+ and CD8+ T cells in JIA indicates their active contribution in sustaining chronic inflammation. Targeting PD-1 could be an effective therapeutic strategy for JIA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Summary: In this study, the deficiency of CD1d-restricted iNKT cells was found to lead to the expansion of Foxp3(-)CD25(+)CD4(+) T cells in colitis. The MLN dendritic cells in DSS-treated Yeti/CD1d KO mice were shown to promote the differentiation of these cells. Furthermore, Foxp3(-)CD25(+)CD4(+) T cells were found to be pathogenic in DSS-treated Yeti/CD1d KO mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Sabine Arve-Butler, Tobias Schmidt, Anki Mossberg, Elisabet Berthold, Birgitta Gullstrand, Anders A. Bengtsson, Fredrik Kahn, Robin Kahn
Summary: Neutrophils in the synovial fluid of children with oligoarticular juvenile idiopathic arthritis (JIA) exhibit an altered phenotype and function, characterized by activation, an aged phenotype, monocyte-like features, and impaired phagocytic capacity. The presence of CD206-expressing neutrophils in the synovial fluid and tissue suggests a potential role in disease pathogenesis. These alterations in neutrophils may contribute to sustained joint inflammation in JIA.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Immunology
Aurileia Aparecida de Brito, Tawany Goncalves Santos, Karine Zanella Herculano, Cintia Estefano-Alves, Cristiano Rodrigo de Alvarenga Nascimento, Nicole Cristine Rigonato-Oliveira, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira
Summary: Photobiomodulation (PBM) therapy attenuates pulmonary inflammation and improves lung function in a chronic experimental asthma model, possibly through the activation of regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Federica Raggi, Martina Bartolucci, Davide Cangelosi, Chiara Rossi, Simone Pelassa, Chiara Trincianti, Andrea Petretto, Giovanni Filocamo, Adele Civino, Alessandra Eva, Angelo Ravelli, Alessandro Consolaro, Maria Carla Bosco
Summary: This study provides the first detailed longitudinal characterization of the EV-proteome in OJIA patients and identifies a panel of deregulated EV-prots that may serve as early molecular indicators for OJIA development, with potential diagnostic and therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Mei-Yu Shen, Bao-Ping Jiang, Ming-Fei Zhang, Xiang Wang, Hong Zhu, Zhen-Ning Gu, Xue-Ping Zhou, Yan Lu, Ling-Ling Zhou
Summary: The study found that miR-143-3p is negatively correlated with the disease activity of rheumatoid arthritis (RA) and is significantly associated with the anti-inflammatory cytokine IL-10. The results showed that miR-143-3p can promote the differentiation of Treg cells and alleviate CIA by reducing inflammatory events.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Biochemical Research Methods
N. Gopalakrishnan, R. Hannam, G. P. Casoni, D. Barriet, J. M. Ribe, M. Haug, O. Halaas
Article
Multidisciplinary Sciences
Jane Atesoh Awuh, Markus Haug, Jennifer Mildenberger, Anne Marstad, Chau Phuc Ngoc Do, Claire Louet, Jorgen Stenvik, Magnus Steigedal, Jan Kristian Damas, Oyvind Halaas, Trude Helen Flo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Biochemical Research Methods
Patrcia Moura Rosa, Nimi Gopalakrishnan, Hany Ibrahim, Markus Haug, Oyvind Halaas
Article
Microbiology
Alexandre Gidon, Signe Elisabeth Asberg, Claire Louet, Liv Ryan, Markus Haug, Trude Helen Flo
Article
Physiology
Korbinian Boesl, Miriam Giambelluca, Markus Haug, Marit Bugge, Terje Espevik, Richard K. Kandasamy, Bjarte Bergstrom
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Immunology
Markus Haug, Gaute Brede, Monika Hakerud, Anne Grete Nedberg, Odrun A. Gederaas, Trude H. Flo, Victoria T. Edwards, Pal K. Selbo, Anders Hogset, Oyvind Halaas
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
N. Kannan, Y-P Lai, M. Haug, M. K. Lilleness, S. S. Bakke, A. Marstad, H. Hov, T. Naustdal, J. E. Afset, T. R. Loerger, T. H. Flo, M. Steigedal
INFECTION AND IMMUNITY
(2019)
Article
Oncology
Anders Tondell, Sissel Gyrid Freim Wahl, Anne-Marit Sponaas, Sveinung Sorhaug, Magne Borset, Markus Haug
TRANSLATIONAL ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Hany Zekaria Meas, Markus Haug, Marianne Sandvold Beckwith, Claire Louet, Liv Ryan, Zhenyi Hu, Johannes Landskron, Svein Arne Nordbo, Kjetil Tasken, Hang Yin, Jan Kristian Damas, Trude Helen Flo
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
Marte S. Dragset, Thomas R. Ioerger, Maja Loevenich, Markus Haug, Niruja Sivakumar, Anne Marstad, Pere Joan Cardona, Geir Klinkenberg, Eric J. Rubin, Magnus Steigedal, Trude H. Flo
Article
Multidisciplinary Sciences
Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Saetra, Haelin Kim, Anne Marstad, Signe E. Asberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Nisha Kannan, Markus Haug, Magnus Steigedal, Trude Helen Flo
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yashwanth Subbannayya, Markus Haug, Sneha M. Pinto, Varshasnata Mohanty, Hany Zakaria Meas, Trude Helen Flo, T. S. Keshava Prasad, Richard K. Kandasamy
Summary: This study conducted label-free high-resolution proteomic profiling of resting and activated CD4+ T cells, identifying significant alterations in the levels of numerous proteins and observed changes in stimulatory/inhibitory immune checkpoint markers between the two states. Network analysis revealed regulatory hubs of CD4+ T cell activation, and comparisons with other cell types indicated interspecies proteomic differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ingrid Nyhus Moen, Marita Westhrin, Erling Haland, Markus Haug, Unni Nonstad, Merisa Klaharn, Therese Standal, Kristian K. Starheim
Summary: Elevated bone-degrading osteoclast activity is associated with diseases like multiple myeloma. Smac-mimetics drugs, by blocking RIPK1 ubiquitination, can impact cell survival and death, and inhibit osteoclast formation, potentially reducing bone degradation.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Anders Tondell, Yashwanth Subbannayya, Sissel Gyrid Freim Wahl, Arnar Flatberg, Sveinung Sorhaug, Magne Borset, Markus Haug
Summary: The study identified two novel immunosuppressive pathways that may dampen the anti-tumor T cell immune response in lung cancer, emphasizing the importance of tumor-associated macrophages as a promising target for immunotherapy. Non-small cell lung carcinoma (NSCLC) commonly shows beneficial responses to immunotherapy with immune checkpoint inhibitors, but only in a proportion of patients. Identification of novel immunosuppressive pathways in NSCLC-associated immune cells is crucial for improving immunotherapy in NSCLC.