On the front line: structural insights into plant–pathogen interactions

Xanthomonas Type III Effector XopD Desumoylates Tomato Transcription Factor SlERF4 to Suppress Ethylene Responses and Promote Pathogen Growth

(2013) Jung-Gun Kim et al.   Cell Host & Microbe

Pseudomonas HopU1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7

(2013) Valerie Nicaise et al.   EMBO JOURNAL

Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t

(2013) Zhi-Min Zhang et al.   JOURNAL OF BIOMOLECULAR NMR

In Vitro Translocation Experiments with RxLR-Reporter Fusion Proteins of Avr1b from Phytophthora sojae and AVR3a from Phytophthora infestans Fail to Demonstrate Specific Autonomous Uptake in Plant and Animal Cells

(2013) Stephan Wawra et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Microbe-Independent Entry of Oomycete RxLR Effectors and Fungal RxLR-Like Effectors Into Plant and Animal Cells Is Specific and Reproducible

(2013) Brett M. Tyler et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Planetary disasters: It could happen one night

(2013) Nicola Jones   NATURE

Interfamily Transfer of Dual NB-LRR Genes Confers Resistance to Multiple Pathogens

(2013) Mari Narusaka et al.   PLoS One

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

The Tomato Prf Complex Is a Molecular Trap for Bacterial Effectors Based on Pto Transphosphorylation

(2013) Vardis Ntoukakis et al.   PLoS Pathogens

A Pathogen Type III Effector with a Novel E3 Ubiquitin Ligase Architecture

(2013) Alexander U. Singer et al.   PLoS Pathogens

Fungal effector Ecp6 outcompetes host immune receptor for chitin binding through intrachain LysM dimerization

(2013) Andrea Sánchez-Vallet et al.   eLife

Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region

(2012) Haishan Gao et al.   CELL RESEARCH

Recognition of methylated DNA by TAL effectors

(2012) Dong Deng et al.   CELL RESEARCH

Activation of a plant nucleotide binding-leucine rich repeat disease resistance protein by a modified self protein

(2012) Brody J. DeYoung et al.   CELLULAR MICROBIOLOGY

Molecular and spatial constraints on NB-LRR receptor signaling

(2012) Katharina Heidrich et al.   CURRENT OPINION IN PLANT BIOLOGY

Plant pattern recognition receptor complexes at the plasma membrane

(2012) Jacqueline Monaghan et al.   CURRENT OPINION IN PLANT BIOLOGY

Plants and pathogens: putting infection strategies and defence mechanisms on the map

(2012) Christine Faulkner et al.   CURRENT OPINION IN PLANT BIOLOGY

TAL effectors: function, structure, engineering and applications

(2012) Amanda Nga-Sze Mak et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nontoxic Nep1-Like Proteins of the Downy Mildew Pathogen Hyaloperonospora arabidopsidis: Repression of Necrosis-Inducing Activity by a Surface-Exposed Region

(2012) Adriana Cabral et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Structural Basis for Interactions of the Phytophthora sojae RxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

(2012) Furong Sun et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases

(2012) Feng Feng et al.   NATURE

Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity

(2012) K. H. Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

(2012) A. N.-S. Mak et al.   SCIENCE

Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

(2012) D. Deng et al.   SCIENCE

Chitin-Induced Dimerization Activates a Plant Immune Receptor

(2012) T. Liu et al.   SCIENCE

How Plant Lysin Motif Receptors Get Activated: Lessons Learned from Structural Biology

(2012) R. Willmann et al.   Science Signaling

Specific DNA-RNA Hybrid Recognition by TAL Effectors

(2012) Ping Yin et al.   Cell Reports

Sequence Divergent RXLR Effectors Share a Structural Fold Conserved across Plant Pathogenic Oomycete Species

(2012) Joe Win et al.   PLoS Pathogens

mADP-RTs: versatile virulence factors from bacterial pathogens of plants and mammals

(2012) Lennart Wirthmueller et al.   Frontiers in Plant Science

Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors

(2011) Alex U. Singer et al.   BIOCHEMISTRY

The Crystal Structure of Necrosis- and Ethylene-Inducing Protein 2 from the Causal Agent of Cacao’s Witches’ Broom Disease Reveals Key Elements for Its Activity

(2011) Gustavo Zaparoli et al.   BIOCHEMISTRY

Programmed cell death in the plant immune system

(2011) N S Coll et al.   CELL DEATH AND DIFFERENTIATION

Structural Analysis of Pseudomonas syringae AvrPtoB Bound to Host BAK1 Reveals Two Similar Kinase-Interacting Domains in a Type III Effector

(2011) Wei Cheng et al.   Cell Host & Microbe

A Receptor-like Cytoplasmic Kinase Phosphorylates the Host Target RIN4, Leading to the Activation of a Plant Innate Immune Receptor

(2011) Jun Liu et al.   Cell Host & Microbe

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death

(2011) Takaki Maekawa et al.   Cell Host & Microbe

Structure Function Analysis of an ADP-ribosyltransferase Type III Effector and Its RNA-binding Target in Plant Immunity

(2011) Byeong-ryool Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures ofPhytophthoraRXLR Effector Proteins

(2011) Laurence S. Boutemy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLR functions in plant and animal immune systems: so far and yet so close

(2011) Takaki Maekawa et al.   NATURE IMMUNOLOGY

Separable Fragments and Membrane Tethering of Arabidopsis RIN4 Regulate Its Suppression of PAMP-Triggered Immunity

(2011) A. J. Afzal et al.   PLANT CELL

Of PAMPs and Effectors: The Blurred PTI-ETI Dichotomy

(2011) Bart P.H.J. Thomma et al.   PLANT CELL

A tomato LysM receptor-like kinase promotes immunity and its kinase activity is inhibited by AvrPtoB

(2011) Lirong Zeng et al.   PLANT JOURNAL

Subcellular localization of the Hpa RxLR effector repertoire identifies a tonoplast-associated protein HaRxL17 that confers enhanced plant susceptibility

(2011) Marie-Cécile Caillaud et al.   PLANT JOURNAL

Structural Resolution of the Complex between a Fungal Polygalacturonase and a Plant Polygalacturonase-Inhibiting Protein by Small-Angle X-Ray Scattering

(2011) M. Benedetti et al.   PLANT PHYSIOLOGY

Showdown at the RXLR motif: Serious differences of opinion in how effector proteins from filamentous eukaryotic pathogens enter plant cells

(2011) J. G. Ellis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol monophosphate-binding interface in the oomycete RXLR effector AVR3a is required for its stability in host cells to modulate plant immunity

(2011) T. Yaeno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaloperonospora arabidopsidisATR1 effector is a repeat protein with distributed recognition surfaces

(2011) Seemay Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant intracellular innate immune receptor Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) is activated at, and functions on, the plasma membrane

(2011) Z. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arabidopsis EDS1 Connects Pathogen Effector Recognition to Cell Compartment-Specific Immune Responses

(2011) K. Heidrich et al.   SCIENCE

TAL Effectors: Customizable Proteins for DNA Targeting

(2011) A. J. Bogdanove et al.   SCIENCE

Pathogen Effectors Target Arabidopsis EDS1 and Alter Its Interactions with Immune Regulators

(2011) S. Bhattacharjee et al.   SCIENCE

Structural Elucidation and Functional Characterization of the Hyaloperonospora arabidopsidis Effector Protein ATR13

(2011) Lauriebeth Leonelli et al.   PLoS Pathogens

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XanthomonasAvrBs3 Family-Type III Effectors: Discovery and Function

(2010) Jens Boch et al.   Annual Review of Phytopathology

Receptor-like Cytoplasmic Kinases Integrate Signaling from Multiple Plant Immune Receptors and Are Targeted by a Pseudomonas syringae Effector

(2010) Jie Zhang et al.   Cell Host & Microbe

The Lysin Motif Receptor-like Kinase (LysM-RLK) CERK1 Is a Major Chitin-binding Protein inArabidopsis thalianaand Subject to Chitin-induced Phosphorylation

(2010) Elena K. Petutschnig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAK1 Is Not a Target of the Pseudomonas syringae Effector AvrPto

(2010) Tingting Xiang et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Plant immunity: towards an integrated view of plant–pathogen interactions

(2010) Peter N. Dodds et al.   NATURE REVIEWS GENETICS

Activation of an Arabidopsis Resistance Protein Is Specified by the in Planta Association of Its Leucine-Rich Repeat Domain with the Cognate Oomycete Effector

(2010) K. V. Krasileva et al.   PLANT CELL

Translocation ofMagnaporthe oryzaeEffectors into Rice Cells and Their Subsequent Cell-to-Cell Movement

(2010) Chang Hyun Khang et al.   PLANT CELL

APseudomonas syringaeADP-Ribosyltransferase InhibitsArabidopsisMitogen-Activated Protein Kinase Kinases

(2010) Yujing Wang et al.   PLANT CELL

Chitooligosaccharide sensing and downstream signaling: contrasted outcomes in pathogenic and beneficial plant–microbe interactions

(2010) Louis-Philippe Hamel et al.   PLANTA

The type III effector HopF2 Pto targets Arabidopsis RIN4 protein to promote Pseudomonas syringae virulence

(2010) M. Wilton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

(2010) R. Morbitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides

(2010) A. Brutus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The repeat domain of the type III effector protein PthA shows a TPR-like structure and undergoes conformational changes upon DNA interaction

(2010) Mário Tyago Murakami et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Armed and Dangerous

(2010)   SCIENCE

Fungal Effector Proteins

(2009) Ioannis Stergiopoulos et al.   Annual Review of Phytopathology

A Renaissance of Elicitors: Perception of Microbe-Associated Molecular Patterns and Danger Signals by Pattern-Recognition Receptors

(2009) Thomas Boller et al.   Annual Review of Plant Biology

AvrPtoB Targets the LysM Receptor Kinase CERK1 to Promote Bacterial Virulence on Plants

(2009) Selena Gimenez-Ibanez et al.   CURRENT BIOLOGY

Direct Binding of a Plant LysM Receptor-like Kinase, LysM RLK1/CERK1, to Chitinin Vitro

(2009) Ei'ichi Iizasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

From bacterial avirulence genes to effector functions via thehrpdelivery system: an overview of 25 years of progress in our understanding of plant innate immunity

(2009) JOHN W. MANSFIELD   MOLECULAR PLANT PATHOLOGY

Emerging Concepts in Effector Biology of Plant-Associated Organisms

(2009) Saskia A. Hogenhout et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The AvrM Effector from Flax Rust Has a Structured C-Terminal Domain and Interacts Directly with the M Resistance Protein

(2009) Ann-Maree Catanzariti et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Proteolysis of a Negative Regulator of Innate Immunity Is Dependent on Resistance Genes in Tomato and Nicotiana benthamiana and Induced by Multiple Bacterial Effectors

(2009) Y. Luo et al.   PLANT CELL

Crystal Structure of the Complex between Pseudomonas Effector AvrPtoB and the Tomato Pto Kinase Reveals Both a Shared and a Unique Interface Compared with AvrPto-Pto

(2009) J. Dong et al.   PLANT CELL

A locus conferring resistance toColletotrichum higginsianumis shared by four geographically distinct Arabidopsis accessions

(2009) Doris Birker et al.   PLANT JOURNAL

RRS1andRPS4provide a dualResistance-gene system against fungal and bacterial pathogens

(2009) Mari Narusaka et al.   PLANT JOURNAL

Fido, a Novel AMPylation Domain Common to Fic, Doc, and AvrB

(2009) Lisa N. Kinch et al.   PLoS One

A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity

(2009) D. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration of evolutionary and desolvation energy analysis identifies functional sites in a plant immunity protein

(2009) M. Casasoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common toxin fold mediates microbial attack and plant defense

(2009) C. Ottmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases

(2009) C. M. Quezada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Terrific Protein Traffic: The Mystery of Effector Protein Delivery by Filamentous Plant Pathogens

(2009) R. Panstruga et al.   SCIENCE

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Host Inhibition of a Bacterial Virulence Effector Triggers Immunity to Infection

(2009) V. Ntoukakis et al.   SCIENCE

Molecular mechanism of pore formation by actinoporins

(2009) Katarina Črnigoj Kristan et al.   TOXICON

NB-LRRs work a “bait and switch” on pathogens

(2009) Sarah M. Collier et al.   TRENDS IN PLANT SCIENCE

RIN4 Functions with Plasma Membrane H+-ATPases to Regulate Stomatal Apertures during Pathogen Attack

(2009) Jun Liu et al.   PLOS BIOLOGY

Bacterial Effectors Target the Common Signaling Partner BAK1 to Disrupt Multiple MAMP Receptor-Signaling Complexes and Impede Plant Immunity

(2008) Libo Shan et al.   Cell Host & Microbe

Plant Pattern-Recognition Receptor FLS2 Is Directed for Degradation by the Bacterial Ubiquitin Ligase AvrPtoB

(2008) Vera Göhre et al.   CURRENT BIOLOGY

Pseudomonas syringae Effector AvrPto Blocks Innate Immunity by Targeting Receptor Kinases

(2008) Tingting Xiang et al.   CURRENT BIOLOGY

Plant pathogenic bacterial type III effectors subdue host responses

(2008) Jian-Min Zhou et al.   CURRENT OPINION IN MICROBIOLOGY

Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation

(2008) Abel Garcia-Pino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

(2008) Alexander U Singer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XopD SUMO Protease Affects Host Transcription, Promotes Pathogen Growth, and Delays Symptom Development in Xanthomonas-Infected Tomato Leaves

(2008) J.-G. Kim et al.   PLANT CELL

From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors

(2008) R. A.L. van der Hoorn et al.   PLANT CELL

A LysM Receptor-Like Kinase Plays a Critical Role in Chitin Signaling and Fungal Resistance in Arabidopsis

(2008) J. Wan et al.   PLANT CELL

ThePseudomonas syringaeeffector protein, AvrRPS4, requiresin plantaprocessing and the KRVY domain to function

(2008) Kee Hoon Sohn et al.   PLANT JOURNAL

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE