Understanding the contribution of synonymous mutations to human disease

Protein Folding at the Exit Tunnel

(2011) Daria V. Fedyukina et al.   Annual Review of Biophysics

Birth, life and death of nascent polypeptide chains

(2011) Sujata Jha et al.   Biotechnology Journal

Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders

(2011) Anna B. Glinskii et al.   CELL CYCLE

ABCB1 Single-Nucleotide Polymorphisms Determine Tacrolimus Response in Patients With Ulcerative Colitis

(2011) K R Herrlinger et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

Proteome Half-Life Dynamics in Living Human Cells

(2011) E. Eden et al.   SCIENCE

Codon optimization of human factor VIII cDNAs leads to high-level expression

(2010) N. J. Ward et al.   BLOOD

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

A Role for Codon Order in Translation Dynamics

(2010) Gina Cannarozzi et al.   CELL

Genetic Polymorphisms Associated with a Prolonged Progression-Free Survival in Patients with Metastatic Renal Cell Cancer Treated with Sunitinib

(2010) A. A. M. van der Veldt et al.   CLINICAL CANCER RESEARCH

Signatures of protein biophysics in coding sequence evolution

(2010) Claus O Wilke et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation

(2010) C. Plinke et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WT1 Synonymous Single Nucleotide Polymorphism rs16754 Correlates With Higher mRNA Expression and Predicts Significantly Improved Outcome in Favorable-Risk Pediatric Acute Myeloid Leukemia: A Report From the Children's Oncology Group

(2010) Phoenix A. Ho et al.   JOURNAL OF CLINICAL ONCOLOGY

Silent mutations in sight: co-variations in tRNA abundance as a key to unravel consequences of silent mutations

(2010) Andreas Czech et al.   Molecular BioSystems

Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line

(2010) Christine Vogel et al.   Molecular Systems Biology

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Non-Synonymous and Synonymous Coding SNPs Show Similar Likelihood and Effect Size of Human Disease Association

(2010) Rong Chen et al.   PLoS One

Gene optimization mechanisms: A multi-gene study reveals a high success rate of full-length human proteins expressed inEscherichia coli

(2010) Barbara Maertens et al.   PROTEIN SCIENCE

A Universal Trend of Reduced mRNA Stability near the Translation-Initiation Site in Prokaryotes and Eukaryotes

(2010) Wanjun Gu et al.   PLoS Computational Biology

Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy

(2010) Klaus Stark et al.   PLoS Genetics

A synonymous mutation inTCOF1causes Treacher Collins syndrome due to mis-splicing of a constitutive exon

(2009) D. Macaya et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genome-wide Association Study of Alcohol Dependence

(2009) Jens Treutlein et al.   ARCHIVES OF GENERAL PSYCHIATRY

Maximum rrn promoter activity in Escherichia coli at saturating concentrations of free RNA polymerase

(2009) M. Ehrenberg et al.   BIOCHIMIE

Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells

(2009) Monika Kaminska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Human tRNA Isodecoders

(2009) Renaud Geslain et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential Involvement of P-Glycoprotein (ABCB1) in Permeability, Tissue Distribution, and Antinociceptive Activity of Methadone, Buprenorphine, and Diprenorphine: In Vitro and In Vivo Evaluation

(2009) Hazem E. Hassan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups

(2009) Shobana Rebecca Dissanayeke et al.   PLoS One

Coding-Sequence Determinants of Gene Expression in Escherichia coli

(2009) G. Kudla et al.   SCIENCE

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

The Price of Silent Mutations

(2009) J. V. Chamary et al.   SCIENTIFIC AMERICAN

Rare Missense and Synonymous Variants in UBE1 Are Associated with X-Linked Infantile Spinal Muscular Atrophy

(2008) Juliane Ramser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Costly Mistakes: Translational Infidelity and Protein Homeostasis

(2008) Evan T. Powers et al.   CELL

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

tRNA's modifications bring order to gene expression

(2008) Estella M Gustilo et al.   CURRENT OPINION IN MICROBIOLOGY

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

A HapMap harvest of insights into the genetics of common disease

(2008) Teri A. Manolio et al.   JOURNAL OF CLINICAL INVESTIGATION

Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Coevolution of Codon Usage and tRNA Genes Leads to Alternative Stable States of Biased Codon Usage

(2008) P. G. Higgs et al.   MOLECULAR BIOLOGY AND EVOLUTION

Following translation by single ribosomes one codon at a time

(2008) Jin-Der Wen et al.   NATURE

Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment

(2008) Jinhai Wang et al.   NATURE BIOTECHNOLOGY

Kinetic barriers and the role of topology in protein and RNA folding

(2008) Tobin R. Sosnick   PROTEIN SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

A pause for thought along the co-translational folding pathway

(2008) Anton A. Komar   TRENDS IN BIOCHEMICAL SCIENCES