Codon optimization of human factor VIII cDNAs leads to high-level expression

Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector

(2009) A. Ramezani et al.   BLOOD

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells

(2009) H. Matsui et al.   BLOOD

Functional roles of the factor VIII B domain

(2009) S. W. PIPE   HAEMOPHILIA

Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A

(2009) Kerry L. Dooriss et al.   HUMAN GENE THERAPY

Directed Engineering of a High-expression Chimeric Transgene as a Strategy for Gene Therapy of Hemophilia A

(2009) Christopher B Doering et al.   MOLECULAR THERAPY

Gene Therapy for Hemophilia: Clinical Trials and Technical Tribulations

(2009) Nicholas Viiala et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Folding at the rhythm of the rare codon beat

(2008) Monica Marin   Biotechnology Journal

Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA